V-Ti-based refractory high entropy alloys (RHEAs), e.g., VTiTa and VTiTaNb, have been found with outstanding mechanical properties and irradiation resistance, granting them application potential in nuclear engineering. Nonetheless, similar to conventional V-Ti-based alloys such as V-4Ti-4Cr, these alloys are sensitive to C/N/O interstitial impurities. Under irradiation, such impurities may promote the formation of precipitates which may affect the defect evolution, especially at the appearance of helium. Previous studies have observed different helium behavior in the above alloys, including the heterogeneous distribution of helium bubbles in VTiTa, but the origin was not clear. In this work, detailed microstructural characterization is performed to analyze the irradiation induced precipitates and their impact on helium bubble formation in these alloys. Under helium ion irradiation at 700°C, the TiN precipitates with the NaCl-type structure are formed in all the three alloys. Nonetheless, the interfaces between precipitates and matrix in VTiTa and VTiTaNb are semi-coherent while those in V-4Ti-4Cr are coherent, due to the various lattice parameters of the alloys. Moreover, severe lattice distortion is also found inside the precipitates in the two RHEAs. Consequently, significant heterogeneous nucleation of He bubbles is observed in these two RHEAs but not in V-4Ti-4Cr. Among the three alloys, the growth of precipitates is the fastest in VTiTa, causing the formation of bubble clusters. Furthermore, the growth direction as well as the shape of precipitates affects the shape of bubbles, leading to the {001} cuboids shape in V-4Ti-4Cr and the truncated {110} dodecahedra shape in V-Ti-Ta and V-Ti-Ta-Nb.