ISEE-675 Objective: To validate estimates of exposure to uranium (U) and radiation in a population of residing around the Feed Materials Production Center (FMPC), a uranium refinery in Fernald, Ohio. Materials and Methods: The FMPC was part of the US Department of Energy (DOE) nuclear weapons complex, and produced uranium metal products during operation from 1952 to 1989. Releases from the site resulted in exposure to soluble and insoluble forms of uranium, and ionizing radiation, especially radon. The Centers for Disease Control and Prevention (CDC) developed dose estimation models for the Fernald area, resulting in an algorithm to estimate exposures to individuals who lived within the exposure assessment domain (area within a 5-mile radius from the perimeter of the plant). We used this algorithm to estimate exposures for 8770 persons enrolled in the Fernald Medical Monitoring Program (FMMP) and then conducted a validation study of 200 members of the cohort, selected on exposure criteria (highest exposure scores, with and without a well or cistern as a drinking water source, and lowest exposure scores, with and without a well as a drinking water source). Urine samples of these 200 persons, collected in the early 1990s, were submitted for urine uranium measurements, with isotopic ratio. Results: Of the first 176 samples measured, level of U ranged from 0.4 to 144.8 ng/L U (ppt). The geometric mean of urine U in the NHANES population, aged 20 years and above, was 0.009 μg/L (ppb) with 95% CI of 0.007–0.010 (CDC, 2005). Of the 176 in the preliminary report, 48% are above the NHANES 95% CI, 8% are above 30 ppt. We will present data on all 200 measurements with isotopic ratio and correspondence with estimates from the statistical models. Conclusions: Measurement of urine U with isotopic ratio is useful in validating an exposure estimation model.
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