The photocatalytic reduction of uranium from nuclear wastewater represents a promising method for both uranium extraction and environmental remediation. This approach facilitates the recovery of uranium resources for the nuclear industry while addressing environmental pollution. Despite significant research advancements, there remains a need for cost-effective and environmentally friendly catalytic materials. In this context, we present a two non-metal O, P co-doped g-C3N4 (OPCN) synthesized via a simple one-step thermo-polymerization in air. OPCN demonstrates a high uranium reduction efficiency of 94.9 % under white LED light illumination. Even after five cycles, OPCN maintained a reduction efficiency of 81.7 %, highlighting its stability and reusability. Additionally, OPCN also performs effectively in uranium reduction under natural sunlight and exhibits impressive antimicrobial properties. These features position OPCN as a promising candidate for practical environmental applications.