110mIn is potentially an important positron emitting that can be used in positron emission tomography. In this work, the excitation functions and production yields of 110Cd(d, 2n), 111Cd(d, 3n), natCd(d, xn), 110Cd(p, n), 111Cd(p, 2n), 112Cd(p, 3n) and natCd(p, xn) reactions to produce the 110mIn were calculated using nuclear model code TALYS and compared with the experimental data. The yield of isomeric state production of 110In was also compared with ground state production ones to reach the optimal energy range of projectile for the high yield production of metastable state. The results indicate that the 110Cd(p, n)110mIn is a high yield reaction with an isomeric ratio (σm/σg) of about 35 within the optimal incident energy range of 15–5MeV. To make the target, cadmium was electroplated on a copper substrate in varying electroplating conditions such as PH, DC current density, temperature and time. A set of cold tests were also performed on the final sample under several thermal shocks to verify target resistance. The best electroplated cadmium target was irradiated with 15MeV protons at current of 100µA for one hour and the production yield of 110mIn and other byproducts were measured.