In neuroimmune communication, the cholinergic system plays a key role in transmitting information vis-à-vis the peripheral immune status to the central nervous system and vice versa. Exposure to ionizing radiations (photons and charged particles) either for medical purposes (radiotherapy and radiodiagnostic) or during radiation accidents can affect the cholinergic system. As such, the administration of cholinergic medications, before or after exposure, can minimize the side effects of ionizing radiation on the cholinergic system. In literature, photon interaction parameters of cholinergic medications have been calculated. However, proton and alpha particle interactions parameters of cholinergic medications have not been investigated. This study, therefore, investigated the mass-stopping power (S(E)/ρ), effective atomic number (Zeff), and electron density (Neff) of 12 cholinergic medications, namely arecoline, carbachol, diisopropyl fluorophosphate, donepezil, malathion, parathion, physostigmine, pilocarpine, rivastigmine, sarin, soman, and tabun for proton and alpha particles interaction. To investigate the parameters of each of the cholinergic medications, a compact and comprehensible cross-platform computer software known as PAGEX was used to compute the S(E)/ρ, Zeff, and Neff for the proton and alpha particle interactions at an energy of 1 keV-10 GeV and 1 keV-1 GeV, respectively. The maximum value of the S(E)/ρ of the cholinergic medications occurred at lower energy regions of about 0.045 ≤ E ≤ 0.1 MeV and 0.5 ≤ E ≤ 0.75 MeV for proton and alpha particle interactions, respectively. Based on the S(E)/ρ, rivastigmine and parathion show the best and least radioprotective ability against proton and alpha particle radiations, respectively. Generally, it was observed that the medications with a lower Zeff have a higher S(E)/ρ than those with a higher Zeff. For both proton and alpha particle interactions, the variation of the Neff with the Zeff has been observed to be linear throughout the entire energy region. It is thought that the S(E)/ρ, Zeff, and Neff of the cholinergic medications for proton and alpha particle interactions investigated in this study will be useful in radiation dosimetry and will also be a buildup on future work that will focus on experimental findings on the radioprotective ability of the investigated medications against charged particle radiations.
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