The Netherlands has a prominent infrastructure in the field of nuclear energy and medical applications. At present the country operates one nuclear power plant, but with an ambition of extending the lifetime of the current nuclear power plant beyond 60 years and construction of two further nuclear power plants in the coming decade. In addition the country plays a significant role in the enrichment of nuclear fuel with two enrichment plants operated in the east of the Netherlands. Furthermore, the Netherlands is the largest producer of medical isotopes in the world, and has some world renowned medical institutes in the field of nuclear medicine. To compliment this infrastructure the Netherlands also contributes to nuclear innovations, through international research and development (R&D). This paper will provide an overview of the Dutch nuclear infrastructure, and it will present the publicly financed R&D program PIONEER which forms the backbone of nuclear research in the Netherlands. The seven intertwined themes of program will be described, together with a single highlight per theme. The paper will also give an outlook on the expected directions for research for the period’25 to’28. Whereas many of the current topics are expected to remain important for the future multiannual program, the plans for expansion of the nuclear power capacity in the Netherlands will lead to a broadening of the scope to support realization of new nuclear power plants in the country, deployment of water-cooled small modular reactors and developments in advanced reactors.