Proton-lead collisions at the Large Hadron Collider energies offer a unique possibility to investigate initial state effects in nuclear collisions. Thanks to its wide acceptance, ATLAS can measure several probes that can help characterise these effects over a wide kinematic range. By analyzing the centrality dependence of dijet production, it is possible to investigate the suppression of dijet events in central collisions compared to peripheral ones and correlate it to the kinematic of the parton-parton scattering, accessible via the measurement of both jets in the final state. Also, the first measurement of the inclusive crosssection for top-quark pair production in dilepton and lepton+jet decay modes is reported. This process is sensitive to effects at high Bjorken-x values, which are hard to access experimentally using other available probes, and thus provides complementary information on the behavior of nuclear parton densities. In 2016, the ATLAS experiment collected 165 nb−1 of proton-lead collisions at a center-of-mass energy of 8.16 TeV per nucleon pair. In this article, new measurements of the centrality dependence of dijet production and the observation of top-quark pair production using this dataset are presented.