This study investigates the nuclear radiation attenuation characteristics of bioactive glasses with the system (26-x)Na2O-xBaO-29CaO–45P2O5, where x represents the molar percentage of BaO (0, 5, 10, 15). For this purpose, several parameters of shielding gamma radiation, such as the mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), half-value layer (HVL), tenth-value layer (TVL), mean free path (MFP), effective atomic number (Zeff), effective electron density (Neff), atomic cross-section (ACS), electronic cross-section (ECS), equivalent atomic number (Zeq), and transmission factor (TF) were calculated. The calculations were performed across different photon energy ranges (0.015–15 MeV) using Phy-X/PSD software and validated using the WinXCOM program. The results obtained from both the software platforms exhibited a high degree of agreement. Among the investigated glasses, the BNCP-15 glass, which had the highest BaO concentration, demonstrated the highest values for MAC, LAC, Zeff, Neff, ACS, ECS, and Zeq, while displaying the minimum values for HVL, TVL, MFP, and TF. For example, the LAC values at 15 MeV were found to be 0.056, 0.063, 0.070, and 0.077/cm for BNCP-0, BNCP-5, BNCP-10, and BNCP-15, respectively. Consequently, the BNCP-15 glass exhibited superior radiation attenuation performance in comparison to the other BNCP glasses examined in this study.