ObjectiveAlthough audio and visual information constitute relevant channels to communicate pain, it remains unclear to what extent observers combine and weight these sources of information when estimating others' pain. The present study aimed to examine this issue through the theoretical framework of the Information Integration Theory. The combination and weighting processes were addressed in view of familiarity with others' pain. MethodTwenty-six participants familiar with pain (novice podiatry clinicians) and thirty non-specialists were asked to estimate the level of pain associated with different displayed locomotor behaviors. Audio and visual information (i.e., sound and gait kinematics) were combined across different intensities and implemented in animated human stick figures performing a walking task (from normal to pathological gaits). ResultsThe novice clinicians and non-specialists relied significantly on gaits and sounds to estimate others' pain intensity. The combination of the two types of information obeyed an averaging rule for the majority of the novice clinicians and an additive rule for the non-specialists. The novice clinicians leaned more on gaits in the absence of limping, whereas they depended more on sounds in the presence of limping. The non-specialists relied more on gaits than on sounds. Overall, the novice clinicians attributed greater pain levels than the non-specialists did. ConclusionDepending on a person's clinical experience, the combination of audio and visual pain-related behavior can qualitatively change the processes related to the assessment of others' pain. Non-verbal pain-related behaviors as well as the clinical implications are discussed in view of the assessment of others' pain.