This study examined whether or not a measure of information processing ability based on the discrimination of novel and familiar stimuli was related to behavioral development among developmentally-delayed infants. Two samples of handicapped infants were administered multiple measures of visual novelty discrimination and a battery of assessments which were representative of available measures of development in infancy. The results indicated that, as a group, the developmentally delayed infants were capable of discriminating novel and familiar stimuli. Also, correlational analyses indicated that responding to novelty was related to developmental accessment performance in both samples. This finding is consistent with previous data which indicates that novelty response measures are associated with important individual differences in young children.