Novel Method For Direct Measurement Research Articles

Sequential Diffusion Spectra as a Tool for Studying Time-Dependent Translational Molecular Dynamics: A Cement Hydration Study.

The translational molecular dynamics in porous materials are affected by the presence of the porous structure that presents an obstacle for diffusing molecules in longer time scales, but not as much in shorter time scales. The characteristic time scales have equivalent frequency ranges of molecular dynamics, where longer time scales correspond to lower frequencies while the shorter time scales correspond to higher frequencies of molecular dynamics. In this study, a novel method for direct measurement of diffusion at a given frequency of translational molecular dynamics is exploited to measure the diffusion spectra, i.e., distribution of diffusion in a wide range of frequencies. This method utilizes NMR modulated gradient spin-echo (MGSE) pulse sequence to measure the signal attenuation during the train of spin-echoes formed in the presence of a constant gradient. From attenuation, the diffusion coefficient at the frequency equal to the inverse double inter-echo time is calculated. The method was employed to study the white cement hydration process by the sequential acquisition of the diffusion spectra. The measured spectra were also analyzed by the diffusion spectra model to obtain the time-dependence of the best-fit model parameters. The presented method can also be applied to study other similar systems with the time evolution of porous structure.

Novel Method for Direct Measurement of Air Gap Anomalies in Direct-Drive Electrical Motors

This paper presents a novel measuring system for detecting air gap anomalies in direct-drive electrical motors. The air gap anomalies can be of different types of eccentricity that may in extreme cases result in a mechanical rub between the stator and rotor, potentially leading to a motor breakdown. A novel measuring method is proposed using a sensory system integrated in a motor air gap to measure its width directly in either a static or dynamic state. It uses an optical sensory (OS) system to measure reflection of the infrared radiation between the rotor and stator. The method is validated by using a parallel measuring system employing an analog Hall sensory (AHS) system that measures the change in the magnetic flux density. The two measuring systems are calibrated by comparing them to a reference laboratory measuring system consisting of a camera and lenses. The calibration is performed in a laboratory in a motor static state within one mechanical rotation cycle of the rotor. Using different calibration techniques, the optimal system accuracy with a maximum permissible error of 0.15 mm is obtained, in the measuring range between 0 and 2 mm. It covers most applications of the direct-drive electrical motors. The new measuring method is validated by using an experimental setup consisting of the presented OS system and validation system consisting of an AHS system integrated on a testing platform (Smart Fortwo car).

A novel method for direct measurement of complement convertases activity in human serum.

Complement convertases are enzymatic complexes that play a central role in sustaining and amplification of the complement cascade. Impairment of complement function leads directly or indirectly to pathological conditions, including higher infection rate, kidney diseases, autoimmune- or neurodegenerative diseases and ischaemia-reperfusion injury. An assay for direct measurement of activity of the convertases in patient sera is not available. Existing assays testing convertase function are based on purified complement components and, thus, convertase formation occurs under non-physiological conditions. We designed a new assay, in which C5 blocking compounds enabled separation of the complement cascade into two phases: the first ending at the stage of C5 convertases and the second ending with membrane attack complex formation. The use of rabbit erythrocytes or antibody-sensitized sheep erythrocytes as the platforms for convertase formation enabled easy readout based on measurement of haemolysis. Thus, properties of patient sera could be studied directly regarding convertase activity and membrane attack complex formation. Another advantage of this assay was the possibility to screen for host factors such as C3 nephritic factor and other anti-complement autoantibodies, or gain-of-function mutations, which prolong the half-life of complement convertases. Herein, we present proof of concept, detailed description and validation of this novel assay.

A Comprehensive Technique for Determining the Intrinsic Light Yield of Scintillators

Precise knowledge of the intrinsic light yield of scintillating materials is important for characterizing, optimizing, and simulating scintillating detectors for radiation detection applications. We present here a comprehensive method for determining the intrinsic light yield of scintillating materials. By maintaining complete control over all aspects of photodetector response measurement, and through the use of a novel method for direct measurement of the light collection efficiency of the scintillator, we have successfully demonstrated that our technique allows for new levels of precision and understanding in the measurement of the intrinsic light yield of scintillating materials.

Noninvasive muscle tension measurement using the novel technique of magnetic resonance elastography (MRE)

A novel method for direct measurement of the state of skeletal muscle contraction is introduced called magnetic resonance elastography (MRE). Such a technique is useful for avoiding the indeterminacy inherent in most inverse dynamic models of the musculoskeletal system. Within a standard MRI scanner, mechanical vibration is applied to muscle via the skin, creating shear waves that penetrate the tissue and propagate along muscle fibers. A gradient echo sequence is used with cyclic motion-encoding to image the propagating shear waves using phase contrast. Individual muscles of interest are identified and the shear wavelength in each is measured. Shear wavelength increases with increasing tissue stiffness and increasing tissue tension. Several ankle muscles were tested simultaneously in normal subjects. Applied ankle moment was isometrically resisted at several different foot positions. Shear wavelengths in relaxed muscle in neutral foot position was 2.34±0.47 cm for tibialis anterior (TA) and 3.13±0.24 cm for lateral gastrocnemius (LG). Wavelength increased in relaxed muscle when stretched (to 3.80±0.28 cm for TA in 45° plantar-flexion and to 3.95±0.43 cm for LG in 20° dorsi-flexion). Wavelength increased more significantly with contraction (to 7.71±0.97 cm in TA for 16 N m dorsi-flexion effort and to 7.90±0.34 cm in LG for 48 Nm plantar-flexion effort). MRE has been shown to be sensitive to both passive and active tension within skeletal muscle making it a promising, noninvasive tool for biomechanical analysis. Since it is based on MRI technology, any muscle, however deep, can be interrogated using equipment commonly available in most health care facilities.

A validated finite element method study of orthodontic tooth movement in the human subject.

The aim of the study was to develop a 3D computer model of the movement of a maxillary incisor tooth when subjected to an orthodontic load. A novel method was to be developed to directly and accurately measure orthodontic tooth movement in a group of human volunteers. This was to be used to validate the finite element-based computer model. The design took the form of a prospective experiment at a laboratory at the University of Wales in 1996/7. A laser apparatus was used to sample tooth movement every 0.01 seconds over a 1-minute cycle for 10 healthy volunteers, whilst a constant 0.39 N load was applied. This process was repeated on eight separate occasions and the most consistent five readings taken for each subject. Data were used to calculate the physical properties of the periodontal ligament (PDL). The data gleaned by this method were used to validate the 3D FEM model. This was formed of 15,000 four-noded tetrahedral elements. Tooth displacements ranged from 0.012 to 0.133 mm. An appropriate elastic modulus of 1 N/mm(2) and Poisson's Ratio of 0.45 was derived for the PDL. Strain analysis, using the model, suggested that a maximum PDL strain of 4.77 x 10(-3) was recorded at the alveolar crest, while the largest apical strain recorded was 1.55 x 10(-3). The maximum strains recorded in the surrounding alveolar bone were 35 times less than for the PDL. A novel method for direct measurement of PDL physical properties in the human subject has been developed. The validated FEM model lends further evidence that the PDL is the main mediator of orthodontic tooth movement.

A novel method for direct measurement of the pKa's of weakly acidic hydrocarbons

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel method for direct measurement of the pKa's of weakly acidic hydrocarbonsJ. O. Stoffer, D. R. Strait, D. L. Filger, E. T. Lloyd, and C. CrainCite this: J. Org. Chem. 1978, 43, 9, 1812–1813Publication Date (Print):April 1, 1978Publication History Published online1 May 2002Published inissue 1 April 1978https://doi.org/10.1021/jo00403a042RIGHTS & PERMISSIONSArticle Views109Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (289 KB) Get e-Alerts Get e-Alerts

Multielement detection limits and sample nebulization efficiencies of an improved ultrasonic nebulizer and a conventional pneumatic nebulizer in inductively coupled plasma-atomic emission spectrometry

Two important aspects of the analytical performance of a newly developed ultrasonic nebulizer and a specially designed pneumatic nebulizer have been compared for use in inductively coupled plasma--atomic emission spectroscopy (ICP-AES). The ultrasonic nebulizer, when combined with a conventional aerosol desolvation apparatus, provided an order of magnitude or more improvement in simultaneous multielement detection limits as compared to those obtained when the pneumatic nebulizer was used either with or without desolvation. Application of a novel method for direct measurement of the overall efficiency of nebulization to the two systems showed that an approximately tenfold greater rate of sample delivery to the plasma torch was primarily responsible for the superior detection limits afforded by the ultrasonic nebulizer. A unique feature of the ultrasonic nebulizer described is the protection against chemical attack which is achieved by completely enclosing the transducer in an acoustically coupled borosilicate glass cylinder. Direct sample introduction, convenient sample change, and rapid cleanout are other important characteristics of the system which make it an attractive alternate to pneumatic nebulizer systems.