Northern Sweden Research Articles

At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study.

BackgroundThe current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture for testing is usually performed by trained staff at healthcare centres. Long travel distances to healthcare centres in rural regions may introduce a bias of testing towards relatively large communities with closer access. Rural regions are therefore often not represented in population-based data.AimThe aim of this retrospective cohort study was to develop and implement a strategy for at-home testing in a rural region of Sweden during spring 2021, and to evaluate its role to provide equal health care for its inhabitants.MethodsWe developed a sensitive method to measure antibodies to the S-protein of SARS-CoV-2 and optimised this assay for clinical use together with a strategy of at-home capillary blood sampling.ResultsWe demonstrated that our ELISA gave comparable results after analysis of capillary blood or serum from SARS-CoV-2-experienced individuals. We demonstrated stability of the assay under conditions that reflected temperature and humidity during winter or summer. By assessment of capillary blood samples from 4,122 individuals, we could show both feasibility of the strategy and that implementation shifted the geographical spread of testing in favour of rural areas.ConclusionImplementation of at-home sampling enabled citizens living in remote rural areas access to centralised and sensitive laboratory antibody tests. The strategy for testing used here could therefore enable disease control authorities to get rapid access to information concerning immunity to infectious diseases, even across vast geographical distance.

An epigenome-wide analysis of sex hormone levels and DNA methylation in male blood samples

ABSTRACT Endogenous sex hormones and DNA methylation both play important roles in various diseases. However, their interplay is largely unknown. A deeper understanding of their interrelationships could provide new insights into the pathology of disease development. We, therefore, investigated associations between circulating sex hormones, sex hormone binding globulin (SHBG), and DNA methylation in blood, using samples from 77 men (65 with repeated samples), from the population-based Northern Sweden Health and Disease Study (NSHDS). DNA methylation was measured in buffy coat using the Infinium Methylation EPIC BeadChip (Illumina). Sex hormone (oestradiol, oestrone, testosterone, androstenedione, dehydroepiandrosterone, and progesterone) and SHBG concentrations were measured in plasma using a high-performance liquid chromatography tandem mass spectrometry (LC/MS-MS) method and an enzyme-linked immunoassay, respectively. Associations between sex hormones, SHBG, and DNA methylation were estimated using both linear regression and mixed-effects models. Additionally, we used the comb-p method to identify differentially methylated regions based on nearby P values. We identified one novel CpG site (cg14319657), at which DNA methylation was associated with dehydroepiandrosterone, surpassing a genome-wide significance level. In addition, more than 40 differentially methylated regions were associated with levels of sex hormones and SHBG and several of these mapped to genes involved in hormone-related diseases. Our findings support a relationship between circulating sex hormones and DNA methylation and suggest that further investigation is warranted, both for validation, further exploration and to gain a deeper understanding of the mechanisms and potential consequences for health and disease.

Optimizing multi-environment testing in potato breeding: using heritability estimates to determine number of replications, sites, and years for field trials

Multi-environment trials (METs) of potato breeding clones and cultivars allow to precisely determine their performance across testing sites over years. However, these METs may be affected by the genotype × environment interaction (GEI) as noted in tuber yield. Furthermore, trials are replicated several times to optimize the predictive value of the data collected because knowledge on spatial and temporal variability of testing environments is often lacking. Hence, the objectives of this research were to use components of variance from METs to estimate broad sense heritability (H2) based on best linear unbiased predictors and use these estimates to determine the optimum number of sites, years, and replications for testing potato breeding clones along with cultivars. The data were taken from METs in southern and northern Sweden comprising up to 256 breeding clones and cultivars that underwent testing using a simple lattice design of 10-plant plots across three sites over 2 years. Percentage starch in the tuber flesh had the largest H2 in each testing environment (0.850–0.976) or across testing environments (0.905–0.921). Total tuber weight per plot also exhibited high H2 (0.720–0.919) in each testing environment or across them (0.726–0.852), despite a significant GEI. Reducing sugar content in the tuber flesh had the lowest, but still medium H2 (0.426–0.883 in each testing environment; 0.718–0.818 across testing environments). The H2 estimates were smaller when their variance components were disaggregated by year and site, instead of lumping them as environments. Simulating H2 with genetic, site, year, site × year, genetic × site, genetic × year, genetic × site × year, and residual variance components led to establish that two replicates at each of two sites in 2-year trials will suffice for testing tuber yield, starch and reducing sugars. This article provides a methodology to optimize the number of testing size and years for METs of potato breeding materials, as well as tabulated information for choosing the appropriate number of trials in same target population of environments.

Simulating glacier mass balance and its contribution to runoff in Northern Sweden

Glaciers are one of the main sources of freshwater in cold regions. The glacier melting process can significantly impact the glacier mass balance (GMB) and contribute a large amount of runoff in cold regions. This study applied the recently developed semi-distributed glacio-hydrological conceptual model (FLEXG) to understand the glacier melting process and the effect of topography on GMB in the Torne River basin, northern Sweden. The study simulated glacier and snow accumulation and ablation, as well as runoff from the glacier and non-glacier areas of the basin using the FLEXG model for the time period 1989–2018. The FLEXG model considers the influence of topography on runoff generation, and in this study the basin was classified into 143 zones depending on elevation and aspect. In order to gain a comprehensive view of the performance of the FLEXG model, the classical lumped hydrological model HBV was used and compared with the FLEXG model in simulating total streamflow and peak runoff at the outlet of the basin. Our results revealed that the FLEXG model performed well in reproducing the streamflow (also better than the HBV model) with metric Kling-Gupta Efficiency (KGE) of 0.80 and 0.71 for the calibration and validation periods, respectively. We also found that the FLEXG model performs better in peak runoff simulation than the HBV model. The FLEXG simulated snow cover area proportion agreed well with the MODIS satellite snow cover product (R2 = 0.60 and RMSE = 28%). The GMB in different elevation zones was simulated, and a downward trend was found for GMB changes during the study period because of climate change.

Public funding and destination evolution in sparsely populated Arctic regions

This paper examines the role of public funding in transforming tourism pathways in sparsely populated Arctic destinations, comparing Northern Sweden and Finnish Lapland. Our theoretical framework considers destination path plasticity and moments of change through the lens of geographical political economy to understand patterns of uneven development. This perspective helps explain how regional development funding driven by multi-scalar political priorities and global markets set structural conditions for tourism. We present a spatial analysis of public funding between 2007 and 2021 for private firms and public projects, complemented by document analysis and expert interviews. We find that public funding in Finnish Lapland has largely reinforced ‘Arctification’ and export-driven tourism in a few locations. In Northern Sweden, it has focused more on redistributing resources to micro-businesses and broader socio-economic development in lagging regions, yet with limited impacts on changing dominant tourism pathways. Public projects improved knowledge creation and networking among public and private actors but were largely unable to consolidate emerging pathways in the long run. Overall, regional development funding supported incremental change around existing pathways and had limited transformative effects in response to shocks or disruptive moments due to the rigid nature of funding programmes.

Children's intervention participation is associated with more positive beliefs towards active school transportation among parents.

Insufficient physical activity among children is a critical issue and health promoting initiatives are required to reverse this trend. In response to the current situation, a school-based intervention aiming to increase physical activity with the aid of active school transportation (AST) was implemented in one municipality in northern Sweden. By adopting the framework of the Theory of Planned Behavior, we aimed to analyse beliefs among parents whose children were or were not involved in the AST intervention. All municipality schools were included. There were 1024 responses from parents, comprising 610 who responded either 'yes' or 'no' to participating in the intervention. An adjusted linear regression analysis showed that children's intervention participation was significantly associated with more positive beliefs towards AST among parents. These results indicates that it is possible to influence beliefs that are important in the parental decision-making process by the use of an AST intervention. Therefore, to make children's active transport to school the more favorable choice for parents, it seems to be worthwhile to not only give children the opportunity to participate but also to involve parents and address their beliefs when designing interventions.

Acute Myocarditis Caused by Francisella tularensis: a Case Report

Myocarditis is an inflammatory disease of the myocardium with either focal or diffuse involvement and usually gives rise to chest pain, dyspnea, palpitations, and fatigue. In severe cases, arrythmias, syncope, and cardiogenic shock may occur. Acute myocarditis is most commonly caused by a variety of viruses with cardiotropic properties. Rare causes of myocarditis include bacterial infections. We, herein, describe a case of acute myocarditis caused by the intracellular bacterium Francisella tularensis. A young and previously healthy male in Northern Sweden was referred to the emergency department due to intense upper-chest pain and dyspnea. ECG exhibited minimal ST-segment elevations and laboratory parameters revealed pathological levels of high-sensitivity cardiac troponin and C-reactive protein. Radiological imaging showed increased metabolism in enlarged lymph nodes in the chest and signs that could be compatible with increased metabolism in the left ventricular of the heart. The combination of acute myocarditis and enlarged lymph nodes was believed to be caused by the intracellular bacterium Francisella tularensis, endemic in the Northern Sweden, and was verified with positive serology. The patient showed full recovery after antimicrobial treatment. As this is the fifth published case of myocarditis associated with Francisella tularensis, we suggest considering tularemia in acute myocarditis in tularemia-endemic area.

Constructing loneliness: Home care providers' notions of older adults' social needs and the possibilities of the home care profession to support social participation

Quality of care is determined not only by political decisions but also by how those policies are understood and managed by professionals when put into action. Home care services, the most common form of elder care in Sweden today, should include social support, which is very important for health and wellbeing. And yet, support for social participation seems to be lacking. Understanding prevalent social constructs and their possible impacts on focus and content of social practice in home care could reveal ways to address social support in home care. Therefore, this article highlights how professionals in home care provision talk about older home care recipients' loneliness and social needs, and how these repertoires are related to professionals' opportunities and obligations to support those social needs. The study included 22 persons from different professions in home care provision, from two municipalities in northern Sweden. Nine individual interviews and four group interviews were conducted, recorded, transcribed, and analyzed using a discourse psychology approach. The results show two interpretative repertoires in which notions of otherness and likeness guided definitions and support regarding loneliness, social needs, and social support. This study reveals assumptions that underpin and structure the practices of home care. As the interpretative repertoires provided differing and partly opposing views on how to provide social support and combat loneliness, it seems important to also address the broader issues of professional identities and how loneliness is defined and approached.

Identification of (E)‐ and (Z)‐11‐tetradecenyl acetate as sex pheromone components of the currant pest Euhyponomeutoides albithoracellus

AbstractThe currant bud moth Euhyponomeutoides albithoracellus is a destructive pest in black currant orchards in Northern Sweden and Finland. The larvae feed on the buds, and at high densities, the species can cause severe yield losses. Sex pheromone components of the bud moth were identified via solvent extraction of excised female pheromone glands, analyses by gas chromatography with electroantennographic detection and gas chromatography–mass spectrometry and field trapping experiments. Antennae of males responded strongly and consistently to two compounds in extracts, identified as (E)‐11‐tetradecenyl acetate and (Z)‐11‐tetradecenyl acetate. Weaker and less consistent responses were observed to the corresponding alcohols, (E)‐11‐tetradecenol and (Z)‐11‐tetradecenol, and tetradecyl acetate. Field tests showed strong attraction of bud moth males to a 1:1 blend of (E)‐11‐tetradecenyl acetate and (Z)‐11‐tetradecenyl acetate. Adding the alcohols to the binary acetate blend reduced trap catches drastically, whereas tetradecyl acetate had no statistically significant impact on male attraction when added to that binary blend. Finally, testing different compositions of the binary acetate blend revealed highest catch in traps baited with a 25:75 or 50:50 ratio of the E:Z acetate isomers. The identification of sex pheromone components of the bud moth contributes to developing sustainable control of this pest via monitoring and mating disruption with sex pheromone.

Food protein-induced enterocolitis syndrome among children in northern Sweden-A retrospective review from 2004-2018.

To describe clinical presentation and development of tolerance among children with Food protein-induced enterocolitis syndrome (FPIES) in a population in northern Sweden. A retrospective review of medical records of children presenting with FPIES symptoms from 1 January 2004, to 31 May 2018. Sixty children (65% boys) with FPIES were included. The estimated incidence gradually increased to 0.45% in 2016-2017. The most common food triggers were cow's milk (40%), fish (37%) and oat (23%). Symptoms presented in 31 (60%) children before 6 months and in 57 (95%) before 1 year of age. The median age for FPIES diagnosis was 7 (range 3-134) months and for fish FPIES 13 (range 7-134) months. By 3 years of age, 67% of children with FPIES to milk and oat but none of the children with fish FPIES had developed tolerance. Allergic conditions like eczema and asthma were reported in 52% of the children. The cumulative FPIES incidence was 0.45% in 2016-2017. Most children presented with symptoms before 1 year of age, but the diagnosis was often delayed, especially for FPIES to fish. Tolerance development occurred at an earlier age when FPIES was triggered by milk and oat compared to fish.

Interaction of smoking and social status on the risk of respiratory outcomes in a Swedish adult population: A Nordic Epilung study

BackgroundEvidence abounds on the independent roles of social class and smoking in relation to obstructive airway diseases, but data are sparse on the impact of their interaction. We evaluated whether and to what extent social class and smoking interact in relation to risk of respiratory diseases in adults. MethodsData from the population-based studies, West Sweden Asthma Study (WSAS, n = 23,753) and Obstructive Lung Disease in Northern Sweden studies (OLIN, n = 6519), were used, constituting randomly selected adults aged 20–75 years. Bayesian network analysis was used to estimate the probability for the interaction between smoking and socioeconomic status in relation to respiratory outcomes. ResultsOccupational and educational SES modified the association between smoking and the probability of allergic and non-allergic asthma. Former smokers who were at intermediate non manual employees and manual workers in service had higher probability of allergic asthma compared to professionals and executives. Furthermore, former smokers with primary education had higher probability of non-allergic asthma than those with secondary and tertiary education. Similarly, former smokers among professionals and executives had higher probability of non-allergic asthma than manual and home workers and primary educated. Likewise, allergic asthma due to former smoking was higher among highly educated compared to low educated. ConclusionsBeyond their independent roles, socioeconomic status and smoking interact in defining the risk of respiratory diseases. Clearer understanding of this interaction can help to identify population subgroups at most need of public health interventions.

Freezers full of gold

The modern chest freezer has significantly altered food storage practices in Sweden. Based on 13 months of ethnographic fieldwork in Arjeplog (rural Northern Sweden/ Swedish Sápmi), this article investigates how the chest freezer plays a crucial role in more-than-human networks of food, sustainability, and living well in the local community. Among participants of this ethnographic study, most of the protein stored in freezers was hunted or foraged from the local landscape, and participants felt “rich and content” with freezers full of “natural” food. Building on theories of new materiality and the more-than-human, I examine the relationships between moose, freezer, forest, and the body, arguing that the chest freezer is not a static object of symbolic meaning but a vibrant actor in these networks of “the good life”. This paper is an empirically grounded contribution to studies of freezing practices and landscape relations in Northern Sweden.

Impact of snow distribution modelling for runoff predictions

AbstractSnow in the mountains is essential for the water cycle in cold regions. The complexity of the snow processes in such an environment makes it challenging for accurate snow and runoff predictions. Various snow modelling approaches have been developed, especially to improve snow predictions. In this study, we compared the ability to improve runoff predictions in the Överuman Catchment, Northern Sweden, using different parametric representations of snow distribution. They included a temperature-based method, a snowfall distribution (SF) function based on wind characteristics and a snow depletion curve (DC). Moreover, we assessed the benefit of using distributed snow observations in addition to runoff in the hydrological model calibration. We found that models with the SF function based on wind characteristics better predicted the snow water equivalent (SWE) close to the peak of accumulation than models without this function. For runoff predictions, models with the SF function and the DC showed good performances (median Nash–Sutcliffe efficiency equal to 0.71). Despite differences among the calibration criteria for the different snow process representations, snow observations in model calibration added values for SWE and runoff predictions.

Old Log Houses in Northern Sweden

Log houses from old times are desirable, since those houses have been standing for maybe 200 years, must be of good quality. How many 50- year-old houses are standing today? The problem is to find craftsmen today that know how these houses were built in case of restoration or modernizing these houses. This chapter may clarify some principles with old log houses. .

Folkskoleväsende och industrialisering i Norra Sverige: Relationer mellan Olofsfors järnbruk och Nordmaling socken vid organiseringen av folkskoleväsendet i 1800-talets decentraliserade skolsystem

Mass-Schooling and pre-industrialisation in Northern Sweden: Relations between Olofsfors Ironworks and Nordmaling parish in the organization of Elementary schools in the 19th century decentralized school system. From the mid-nineteenth century, Sweden went through a transformation from an agricultural to an industrial society which led to new demands on the parishes. With the First Elementary School Act in 1842, Sweden’s school system was formalised. The decentralised system formed by the First Elementary School Act, stated that every parish should establish at least one school in every parish. At this time, half of Sweden’s parishes already had some form of public schools, which were run by parishes, private organisations, donations, or pre-industrial companies, as for example Ironworks. Regardless of who ran the school, the parish was responsible and were the one who would report school results to the bishop’s office, so the relationship between the private actor and the parish was important. In this article we study how the relationship between Olofsfors Ironwork and the local parish, Nordmaling developed during the nineteenth century, and how these turbulent times affected the relationship. This is discussed in relation to earlier research and has been analysed through discourse analysis.

Stimulating algal growth through wood ash fertilization in the Åkerberg pit lake, northern Sweden

Fifteen microcosms were installed in the Åkerberg pit lake for 15 days in the summer season (July) 2021. To stimulate algal growth, the microcosms were fertilized with two P-rich wood ashes, and KNO3. Chlorophyll-a was used as an indicator of algal growth while filtered (<0.2 μm) and particulate suspended element concentrations (>0.2 μm) were used to estimate algal metal uptake. Water quality measurements and water sampling were conducted on three occasions (every five days) and at the start of the experiment to monitor algal growth. The chlorophyll-a concentration in the microcosms fertilized with wood ash increased from 0.3-0.8 μg/L at the start of the experiment to 53–77 μg/L after 15 days. Algal element uptake of filtered concentrations (<0.2 μm) was observed for many elements including, Ni (33–36%), Zn (22–65%) and Cd (22–54%). This suggests that wood ash could be used to stimulate algal growth in pit lakes by acting as a source for P and potentially also other nutrients. The highest chlorophyll-a concentrations were seen on day 10, indicating that a breakdown of chlorophyll-a impacted the measured concentrations, which otherwise could have been higher.

Neighbourhood social sustainable development and spatial scale: a qualitative case study in Sweden

ABSTRACT Social sustainability has increasingly become a goal for urban policy and planning, and for local and regional developmental strategies. Neighbourhoods are a common spatial scale for studying social sustainability and there is a growing focus on social sustainability in urban neighbourhoods for both researchers and policymakers. This paper is based on a qualitative case study of a neighbourhood defined by the municipality as at-risk of negative social development in a municipality in northern Sweden. The aim is to describe the perceived threats and promoters for social sustainable development in a neighbourhood defined as at-risk, and to analyse these in relation to a perspective of spatial scale. The study is based on data from interviews with municipal representatives, local professionals and residents, representing different experiences and perspectives in the neighbourhood. Four themes illustrating threats to socially sustainable development were identified: crime, unrest and unsafety; segregation and social exclusion; reputation and stigmatisation; and low involvement in municipal processes. The promoters for socially sustainable development identified in the respondents’ stories reflect four themes: strong community spirit; safety and low criminality; lively civic society and well-functioning public services. Our results show that neighbourhood social sustainability cannot be studied or acted upon without being put in a context of spatial scale and an understanding that processes occurring at a particular scale only can be adequately understood when considered in relation to other scales, i.e. the development in the neighbourhood can only be understood in relation to the development in the city and at national level. There is also a need for an awareness of how different aspects of socially sustainable development relate to each other, by strengthening or counteracting each other. Key policy highlights There are no “magic bullet solutions” to ensure social sustainable development at the local level. Rather, actions and interventions must embrace complexity. The risk for counteracting processes must be acknowledged in any actions to promote social sustainability. Social sustainability processes occurring at a particular scale can only be adequately understood and addressed when considered in relation to other scales.

"It's Kind of Our Everyday Life. It Sort of Becomes Natural": Everyday Violence and Violent Practices Among Young People.

Although violence among youth remains an important, global issue, little research has been conducted regarding how young people themselves define violence and what practices in relation to violence that are evident in their everyday lives. Using an intersectional gender perspective, specifically exploring the intersection of gender, age, and class, this paper therefore aims to explore how young people define violence, as well as to explore what practices in relation to violence that are evident in young people's everyday lives. By using a photovoice methodology, 11 focus groups of young boys and girls (17-19 years old) living in two municipalities in northern Sweden were interviewed and asked to take photographs representing themes that were discussed. Overall, three main themes in the young peoples' stories were identified: Violence as ubiquitous, Easy prey and dangerous predators, and The way forward. The findings demonstrated that violence is pervasive, all-encompassing and normalized in young people's everyday lives, and that this violence is moderated by intersecting power orders of gender, age, and class. Any future theoretical frameworks or prevention strategies should therefore aim to include an intersectional perspective as well as including the voices of the youths themselves.

Molecular studies of rust on European aspen suggest an autochthonous relationship shaped by genotype.

Forests are at increasing risk from pathogen outbreak. Climate change for example enhance the risk of local disease outbreaks, and naturalization of exotic pathogens may follow human activities, warranting robust pest surveillance routines to support forest management. Melampsora pinitorqua (pine twisting rust) is of concern in Swedish forestry, and here we evaluate the use of visible rust scores (VRS) on its obligate summer host, European aspen (Populus tremula) as a tool for quantification of the pathogen. With use of species-specific primers, we could detect the native rust, but we failed to detect two exotic rusts (M. medusae and M. larici-populina). We found that aspen genotype determined the presence of fungal genetic markers (amplifying the ITS2 region of the fungal rDNA sequence) as well as DNA sequences specific to M. pinitorqua. We correlated VRS with the amount of fungal DNA in the same leaf, and we related the findings to aspen genotype-specific parameters such as the ability to synthesize and store leaf condensed tannins (CT). At the genotype level both positive and negative relationships were observed between CTs, fungal markers, and rust infestations. However, at the population level, foliar CT concentrations correlated negatively with general fungal- and rust-specific marker abundances. Our results, therefore, do not support the use of VRS to assess Melampsora infestation in Aspen. They do, however, suggest that the relationship between European aspen and rust infestation may be characterized as autochthonous in northern Sweden.

Rural mobilites and urban norms

This article deals with everyday life in sparsely populated parts of northern Sweden. It investigates the relationship between local practice and political discourses. The discussion is based on fieldwork carried out in two northern municipalities. Empirical themes include everyday life mobilities and means of transport. The theoretical concepts of everyday life, community, place, and policy shape the analysis of processes pertaining to space and movement. In particular, the article discusses sustainable development as policy and argues for alternative understandings of social sustainability in relation torural settings. Keywords: everyday life mobilities, means of transport, sparsely populated parts of northernSweden, place, policy, sustainable development, social sustainability Key words: everyday life mobilities, means of transport, sparsely populated parts of Northern Sweden, place, policy, sustainable development, social sustainability