Controversy surrounds the forming time and tectonic background of the Kaijiang–Liangping Trough in the northern Sichuan Basin. The Wuchiapingian Formation, surrounding this Late Permian trough, contains tuffs, and industrial gas reservoirs have been discovered. However, the genesis of these tuffs, revealed by the drilling wells, remains unclear. In the present work, we analyzed the samples of sedimentary tuff from the core of the study area by macroscopic and microscopic analysis, combined with whole-rock major and trace element analysis, zircon U-Pb dating, and zircon trace element analysis, defining the genesis of the Wuchiapingian Formation tuffs around the Kaijiang–Liangping Trough, in an attempt to describe the initial tectonic context of the trough. The U-Pb ages of the tuffs measured in this study range from 255 to 259 Ma. They are slightly later than the activity of the Emeishan Large Igneous Province. Considering the trough’s distance from the center of the Emeishan Large Igneous Province and its location in the outer zone, it is more likely associated with acidic volcanic eruptions of the island arc. The arc was formed by the subduction activity of the Mianlue Ocean beneath the northern Yangtze Plate. In terms of the timing of activity and the tectonic position of the subduction zone, the Kaijiang–Liangping trough in the northern Sichuan Basin is more closely related to the closing of the Mianlue Ocean.