Northern Serbia Research Articles

Exploring the bioactivity potential of indigenous Ganoderma species from Northern Serbia: insights into antioxidant and anti-acetylcholinesterase properties.

This study explores the bioactivity potential of four indigenous Ganoderma species from northern Serbia (G. applanatum, G. lucidum, G. pfeifferi, and G. resinaceum), comparing antioxidant and anti-acetylcholinesterase (anti-AChE) properties. The mycochemical profile, including ethanol (EtOH), water (H2O), and chloroform (CHCl3) extracts, was analysed, revealing significant phenolic compounds, such as 2,5-dihydroxybenzoic acid. Highest total phenolic content (TP) was in EtOH extracts (205 - 380 mg GAE/g d.w.), and total carbohydrate content peaked in G. pfeifferi CHCl3 extracts (1895 ± 0.29 mg GluE/g d.w., 439 ± 0.42 mg FruE/g d.w.). DPPH and FRAP activities were prominent in G. applanatum H2O extracts, while CHCl3 extracts excelled in the NO assay, and EtOH extracts were superior in the ABTS assay. The most effective AChE inhibitors were polar extracts from G. pfeifferi. These findings emphasise the potential therapeutic use of Ganoderma species, particularly G. pfeifferi, in combating oxidative stress and acetylcholine deficiencies.

To pretreat, or not to pretreat, that is the question. The value of pretreatment protocols in the stable carbon and nitrogen isotope analysis of archaeobotanical cereal grains from Croatia and Serbia

ABSTRACT Isotopic analysis of archaeological charred plant remains is a useful tool to infer past agricultural practices. However, debate continues over whether charred seeds should be untreated or pretreated before analysis, to counteract any residual contamination and retrieve the “true” isotopic signature of the seed. This paper presents a case study examining whether archaeobotanical remains from Croatia and northern Serbia should be pretreated before isotopic analysis with the aim to provide a pragmatic technique for wider application. A small subset was first examined with an ATR-FTIR and then four different protocols were examined: water rinse only, two different acid-only methods and ABA (acid–base-acid). The results were inconsistent, displaying variability in the effect each protocol had on the isotopic values. Overall, it was concluded that the slight differences between untreated and pretreated sub-samples should not impact the archaeological interpretation, removing the need for pretreatment of the remaining archaeobotanical material.

Effects of nutritional education on metabolic syndrome parameters in a sample of adults in Subotica, Northern Serbia

The aim of this study is to assess the changes in metabolic syndrome parameters among adults after the implementation of nutrition education. The research was conducted as a prospective, longitudinal, quasi-experimental evaluation study from May to December 2022. The research sample included 31 employees at the College of Vocational Studies in Subotica. The study was conducted in three phases: Initial assessment (anthropometric, clinical, biochemical measurements and eating habits), Nutrition educations (onloine and face-to-dace) and Evaluative assessment (six months after the initial assessment). Data analysis included methods of descriptive and comparative statistical analysis. Nutrition education was conducted for 31 participants, but only 18 responded to the evaluative assessment. Two thirds (62%) of the participants were overweight ad had elevated cholesterol levels. Elevated triglyceride values were registered in more than a half of the participants and high blood glucose levels in 13% of participants. More than a third of the participants had three or four risk factors for the development of metabolic syndrome. After nutrition education, distribution of participants according io BMI significantly changed (I—normal: 37%; overveigt: 31%; obese:29%; E—normal:10%; overveigt:29%; obese:19%; p = 0,001). Significant changes in the distribution of total cholesterol levels (I: 5.7 mmol/l; E: 5.4 mmol/l) was determined at the evaluative assessment (p = 0.005). Statistically changes in the distribution of breakfast (p = 0.001) and vegetables (p = 0.013) intake were observed. There were not determined significant changes in other antropometric, clinical and biochemical parameters after nutrition education. Although the nutrition education intervention showed some changes in the prevalence of risk factors, significant changes require more intensive, long-term interventions tailored to individual needs.

Monitoring of Herbicide Residues in Agricultural Soils in Vojvodina Province (Northern Serbia)

Pesticides in soils raise concerns about the biodiversity, food safety, and contamination of watercourses, contributing to unsustainable land management practices. Monitoring the residue levels in agricultural soils is essential, as this offers valuable insights into the current extent of soil contamination and potential environmental risks attributed to their application. This study aimed to address the occurrence of the currently used herbicides in soil under intensive crop production, comparing the results of monitoring at two depths (0–30 and 30–60 cm) in 2013 and 2023. The research concerned the main agricultural area in Vojvodina Province (Serbia) and evaluated the presence of 41 herbicides in 128 localities. Pesticides were found in all samples, finding even more than six different herbicides per sample. The significant concentrations of s-metolachlor, etofumesate, clomazone, diflufenican, pendimethalin, and terbuthylazine found can be attributed to application practices, as they are typically applied pre-emergence, either through direct soil treatment with or without incorporation. Moreover, the correlation between different depths, herbicide residues, and soil properties was not significant. The decrease in the herbicide residues found in 2023 compared to the residues found in 2013 can be attributed to the implementation of good agricultural practices, which promote sustainable agricultural strategies through controlled pesticide application.

Institutional, Ecological, Economic, and Socio-Cultural Sustainability—Evidence from Ponjavica Nature Park

The Nature Park Ponjavica (NP) is the habitat of strictly protected plant and animal species, located in AP Vojvodina, in southern Banat (Northern Serbia). The area of the park covers 302.96 ha. Protection zones I, II, and III have been established in the protected area of the NP. The NP includes the middle course of the Ponjavica River, which has preserved characteristics of watercourses of plain areas and coastal remains of wetland habitats. The most valuable area of this park in terms of protection is an island with an area of slightly less than 1 hectare. According to the IUCN (International Union for Conservation of Nature), the NP is classified as the fourth category—Habitat and species management area. The good geographical position of NP is one of its main characteristics. The NP can be a destination where specific forms of tourism can be developed, such as ecotourism, nature-based tourism, birdwatching, scientific and research tourism, etc. Numerous historical sites represent a significant potential for the development of cultural tourism. The research examined the influence of institutional, economic, ecological, and socio-cultural sustainability on the respondents’ satisfaction. The quantitative methodology in this research included a questionnaire as a survey instrument for respondents. A total of 547 residents were surveyed. The results of the research indicate that there is considerable satisfaction among residents with sustainable tourism. The results of the research can help in the development of numerous tourism development strategies in which the wetland is the primary resource.

PROFITABILITY OF ORGANIC FARMING OF SPELT IN THE CLIMATE CONDITIONS OF SERBIA

This research focuses on assessing the general profitability of organically produced spelt. Spelt is an ancient grain that has experienced a resurgence in Serbia in the late seventies of the previous century, due to its exceptional nutritional value and high compatibility with organic farming. Field experiments were conducted in northern Serbia over four years, applying further financial analysis. The main goal of the research is to identify and quantify the costs, benefits, and general profitability of organic production of spelt in the climatic conditions of Serbia. Results indicate that organically produced spelt is economically profitable, primarily due to its significantly higher market price compared to conventionally produced spelt. Given climate change concerns, promoting the cultivation of climateresilient crops, like spelt, becomes crucial. Organic spelt cultivation could play a significant role in adapting crops to climate change, emphasizing the need for activities that mitigate negative environmental impacts.

Exploring the effects of habitat management on grassland biodiversity: A case study from northern Serbia.

Grasslands represent a biodiversity hotspot in the European agricultural landscape, their restoration is necessary and offers a great opportunity to mitigate or halt harmful processes. These measures require a comprehensive knowledge of historical landscape changes, but also adequate management strategies. The required data was gathered from the sand grasslands of northern Serbia, as this habitat is of high conservation priority. This area also has a long history of different habitat management approaches (grazing and mowing versus unmanaged), which has been documented over of the last two decades. This dataset enabled us to quantify the effects of different measures across multiple taxa (plants, insect pollinators, and birds). We linked the gathered data on plants, pollinators, and birds with habitat management measures. Our results show that, at the taxon level, the adopted management strategies were beneficial for species richness, abundance, and composition, as the highest diversity of plant, insect pollinator, and bird species was found in managed areas. Thus, an innovative modelling approach was adopted in this work to identify and explain the effects of management practices on changes in habitat communities. The findings yielded can be used in the decision making as well as development of new management programmes. We thus posit that, when restoring and establishing particular communities, priority needs to be given to species with a broad ecological response. We recommend using the decision tree as a suitable machine learning model for this purpose.

Contamination levels, influencing factors, and risk assessment of polybrominated diphenyl ethers in house dust of northern Serbia.

Polybrominated diphenyl ethers (PBDEs) are a group of compounds that, due to their applications, are considered mainly indoor contaminants. To obtain the first information about the presence of PBDEs in Serbia, dust samples (n = 50) were collected in settlements in the northern Serbian province of Vojvodina. The selected/target congeners (BDE-28, 47, 99, 100, 153, 154, and 183) were extracted from house dust by microwave-assisted extraction technique, and purified extracts were analyzed on a dual-column gas chromatograph with micro-electron capture detectors. A wide range of ΣPBDEs was detected (0.295 to 394 ng g-1 dust), which reflects large differences in contamination among the examined homes. For the majority of samples (72%), ΣPBDEs were lower than 5 ng g-1 indicating that people living in Vojvodina province are exposed to low concentrations of PBDEs present in their households. Based on principal component analysis (PCA), balcony areas and age of the house positively correlate with the PBDE congeners with higher detection frequencies (≥ 50%), namely, with BDE-99, BDE-153, and BDE-183. Statistically significant positive correlation (p < 0.01) was obtained for BDE-99 and the number of household's members. Estimated daily intakes (EDItot) were calculated for ingestion and dermal absorption of dust for two age groups-adults and toddlers. These arethe first data on PBDE status in the area of the Western Balkan, and the health risk assessment indicates that PBDE levels obtained in household dust do not pose a risk for human health.

Long Time No Hear, Magnificent Wohlfahrtia! Morphological and Molecular Evidence of Almost Forgotten Flesh Fly in Serbia and Western Balkans.

The "beautiful viviparous fly", Wohlfahrtia magnifica, may have a magnificent appearance due to its striking morphology; however, it is a potentially deadly agent of obligate traumatic myiasis in humans and animals, with a serious impact on welfare and economics. The fly is found across the Palearctic realm, including the Western Balkan region, with reports from former Yugoslavian countries from the first half of the 20th century. In this paper, a recent case of wohlfahrtiosis recorded in Northern Serbia is evidenced using morphological and molecular techniques. Larvae were collected from two adult sheep with severe hoof myiasis and two young sheep with genital and interdigital myiasis. Morphological identification was performed for adults bred from the infested vulva and third-stage larvae (L3) collected from the hoof wounds, supported with barcoding sequences of the COI gene obtained from larval pairs from the hoof wounds of older and the genitalia of younger sheep. W. magnifica was identified according to the appearance of male fly terminalia and the morphology of L3, which was confirmed after the comparison of representative sequences of the COI gene (deposited in GenBank™ under accession numbers MT027108-MT027114) to those available in GenBank™. This finding represents the first reported case of wohlfahrtiosis in the Western Balkans in 80 years, highlighting the need to re-inform relevant stakeholders to achieve adequate disease control.

The relationship between the loess stratigraphy in the Vojvodina region of northern Serbia and the Saalian and Rissian Stage glaciations – a review

The regional loess stratigraphy in the Vojvodina region, in the southeastern Carpathian Basin, has often been successfully correlated to the global palaeoclimate. This is a quasi‐continuous sedimentary record that provides detailed environmental reconstruction during the last four glacial/interglacial cycles. In this study, we present a standardized loess stratigraphy and illustrate how it correlates with the marine oxygen isotope and Chinese loess stratigraphical records. We argue that the loess stratigraphy in Vojvodina region is an important link in the integration of European terrestrial stratigraphical schemes and the deep‐sea stratigraphical model. We highlight how the loess record can better illustrate terrestrial environmental change through multiple glacial cycles than other records, such as glacial records. The investigated loess record enables direct links to be made between the loess sediments and their glacial sources. This reveals evidence of glaciations during every glacial cycle of the Saalian Stage complex, equivalent to Marine Isotope Stage (MIS) 10, 8 and 6. Therefore, Serbian loess has the potential to provide a direct link between terrestrial glaciations and wider records of global climate change, which is an enigma for many other continental records. These loess records display a strong relationship with the intensity of European glaciations during different glacial cycles. Loess sedimentation rates are highest in the most intensive European glaciation of the Saalian complex (MIS 6) and much lower during the weaker ‘missing’ glaciations equivalent to MIS 8 and 10. A key observation from the Vojvodina loess is the gradual increase in interglacial aridity through the late Middle Pleistocene. The explanation for the progressively increasing aridity in the investigated region at this time is still unclear. However, this trend is consistent with the idea of the Saalian complex as representing a 400 ka mega glacial cycle modulated by shorter classic 100 ka glacial cycles.

Water quality evaluation of the Danube River basin in Bačka (northern Serbia) using multivariate statistical techniques

The study aimed to analyze changes in water quality based on ten physicochemical parameters for the Danube River in Bačka. Data from three profiles over a twenty-year interval were used and processed using multivariate statistics. An ANOVA indicated that the quality of surface water is mostly at a satisfactory level. Sufficient amounts of dissolved oxygen indicate a favorable aeration regime. The surpassing of the annual and monthly values of suspended solids was recorded for all profiles (especially in summer). The summary results show that most parameters, except for suspended solids, are within the allowed values for water quality Class II. A Pearson’s correlation test indicates a moderate to weak correlation of the analyzed parameters. A PCA analysis determined the influence of (a) eutrophication processes; (b) ecological factors; and (c) concentrated sources of pollution. Changes in the Danube’s water quality, primarily increased concentrations of suspended solids, can exert a limiting influence on some economic activities and their planning.

Polyurethane-Degrading Potential of Alkaline Groundwater Bacteria.

Plastic waste is a global environmental burden and long-lasting plastic polymers, including ubiquitous and toxic polyurethanes (PUs), rapidly accumulate in the water environments. In this study, samples were collected from the three alkaline groundwater occurrences in the geotectonic regions of the Pannonian basin of northern Serbia (Torda and Slankamen Banja) and Inner Dinarides of western Serbia (Mokra Gora) with aim to isolate and identify bacteria with plastic- and lignocellulose-degrading potential, that could be applied to reduce the burden of environmental plastic pollution. The investigated occurrences belong to cold, mildly alkaline (pH: 7.6-7.9) brackish and hyperalkaline (pH: 11.5) fresh groundwaters of the SO4 - Na + K, Cl - Na + K and OH, Cl - Ca, Na + K genetic type. Full-length 16S rDNA sequencing, using Oxford Nanopore sequencing device, was performed with DNA extracted from colonies obtained by cultivation of all groundwater samples, as well as with DNA extracted directly from one groundwater sample. The most abundant genera belong to Pseudomonas, Acidovorax, Kocuria and Methylotenera. All screened isolates (100%) had the ability to grow on at least 3 of the tested plastic and lignocellulosic substrates, with 53.9% isolates degrading plastic substrate Impranil® DLN-SD (SD), a model compound for PUs degradation. Isolates degrading SD that were identified by partial 16S rDNA sequencing belong to the Stenotrophomonas, Pseudomonas, Paraburkholderia, Aeromonas, Vibrio and Acidovorax genera. Taking into account that plastics, including commonly produced PUs, are widespread in groundwater, identification of PUs-degrading bacteria may have potential applications in bioremediation of groundwater polluted with this polymer.

Economic burden of breast cancer in northern Serbia.

Breast cancer is the most common cancer in terms of incidence and mortality among all cancers in women in Vojvodina, the northern region of Serbia. In addition to the effectiveness and safety of therapy, it is important to put emphasis on the cost of treatment, as well as on the optimal allocation of limited resources. This study aimed to assess the overall economic burden of breast cancer in Vojvodina, as well as the ratio of direct and indirect costs in 2019. Costs were estimated using Cost of Illness (COI) evaluation, from a social perspective, based on the prevalence of the disease. The total costs included both direct and indirect expenditures. Direct costs associated with breast cancer comprised expenses linked to screening, hospital treatment, outpatient care, and prescribed medications. Indirect costs were estimated using a human capital approach, encompassing expenditures tied to lost productivity arising from sick leave, early retirement, and premature death. The total cost of breast cancer in Vojvodina during 2019 was estimated to be 15 million euros. Among the total cost, direct costs accounted for 5 million euros, representing 34% of the overall expenses. Hospital treatment costs accounted for 76% of the direct costs, while screening costs represented 1%. Indirect costs amounted to 10 million euros, constituting 66% of the total cost. The primary driver was attributed to production losses caused by premature retirement, which accounted for 50% of the indirect costs. Breast cancer is a huge financial burden on both the health system and society in Vojvodina, accounting for 0.12% GDP. The dominance of indirect costs in total costs, can provide significant guidance to decision-makers in the healthcare system in terms of better allocation of limited resources to breast cancer prevention and early detection strategies.

An assessment of historical short-time precipitation deficiency in eastern Slovakia and northern Serbia according to the SPI-3

An assessment of historical short-time precipitation deficiency in eastern Slovakia and northern Serbia according to the SPI-3

Glass trade through the Adriatic Sea: preliminary report of an ongoing project

A repertoire of 1357 glass samples from Italy, Croatia, Slovenia and Serbia was used to investigate glass trade in the Adriatic Sea. The achieved overview begins in the 1st century and, after a peak of occurrences between the 4th and the 7th century, continues until the 16th with a decreasing number of pieces of evidence.Between the 1st and the 3rd century, Levantine (Roman Mn) and Egyptian (Roman Sb) products coexist in percentages that can be considered comparable at the current state of studies. The end of the 3rd and the beginning of the 4th century mark a substantial decrease in Levantine imports. Indeed, Jalame-type glass first and Apollonia-type glass later appear to supply a small slice of the market. Egyptian products, on the contrary, continue to arrive in abundance. The HIMTa and the Foy Série 2.1 glass represent the most widespread products in the Adriatic area for about three centuries. Conversely, the Foy Série 3.2 experiences flowering in northern Italy, Slovenia and Serbia, while it shows limited diffusion in southern Italy, as well as in Tyrrhenian Italy, Sicily or other areas of the Mediterranean basin such as Spain. Based on this observation, it thus seems reliable to exclude Foy Série 3.2 glass from the basket of products typically marketed in the Adriatic Sea (i.e. Levantine products and Egyptian products of types HIMTa-b and Foy 2.1). In this case, a Balkan route may appear possible because it covers the territories where the most significant diffusion of this glass has been observed and is well connected to northern Italy through the Danube and Sava rivers. In southern Italy, the need for more data on the oldest productions prevents a reliable evaluation of Roman Mn and Roman Sb glass imports and highlights a line of research to be pursued in the immediate future.

Water Supply Systems for Settlements with Arsenic-Contaminated Groundwater—Making the Right Choice

The environmentally and economically sustainable provision of safe drinking water remains one of the most significant public health challenges facing society. It is particularly difficult in small municipalities that lack the human and financial resources to maintain complex and/or expensive water treatment systems, especially in regions where the water is naturally contaminated with toxic substances such as arsenic. This paper analyses two municipalities (Kanjiža and Senta) in northern Serbia with groundwater arsenic concentrations significantly higher than the 10 µg/L maximum allowable concentration. Two different water supply approaches are compared: (1) local supply, where each settlement has their own treatment plant using existing sources; (2) creation of a centralised network, which connects several settlements together with better quality water sources. The analysis considers techno-economical aspects and the quantity and quality of available water, as well as the yields investment and exploitation cost projections for both approaches. The results demonstrate that for small municipalities, a holistic approach to decision making is necessary to find the best solutions for drinking water supply, which in the case of the two municipalities studied is connection to a centralised system supplied from better quality water sources and the creation of connections beyond municipal administrative boundaries.

Initial results of the colorimetric indices of the oldest exposed pedocomplex (Titel loess plateau, Serbia)

n this study we present an in-depth description of the colorimetric values for the lowest section of the Dukatar Loess Palaeosol Sequence (LPS) pedocomplex S5. Formed during the Marine Isotope Stage (MIS) 13-15, it represents the oldest pedocomplex exposed at the base of the Titel loess plateau (TLP), near the confluence of the Tisa and Danube rivers in Vojvodina (northern Serbia). The results of low-field magnetic susceptibility measurements (χlf) were compared to colour properties (obtained by conventional methods as well as instrumental measuring) and quantified Soil Development Indices (SDI). Of these measurements we found that the Redness Index (RI1) yielded the most useful results, as this index appears most sensitive to lithological changes and soil development intensity. It was also observed that a high level of correlation existed between χlf, and a* chromaticity. The initial results of this study highlight the utility of colorimetric methods as an interdisciplinary tool when evaluating the presence of ferromagnetics, and the application of rock magnetism to the Middle and Upper Pleistocene LPS of the Middle Danube Basin. The presented approach can be used to observe the evolution of climatic and ecological conditions in the given study area, and for establishing correlations between sites extending over the Eurasian LPS provinces.

Real-world data on survival outcomes and characteristics of lung cancer patients in northern serbia.

e22528 Background: Serbia is the one of the countries with the highest incidence and mortality of lung cancer in Europe and survival rates are very low. Despite that fact, there is no recent data published on the incidence, mortality, survival time or the most significant patient characteristics for the Northern Serbian Province of Vojvodina. Methods: For the purpose of this retrospective study data for the period 2010 to 2022 were collected from Institute for Pulmonary Diseases of Vojvodina Hospital Information System and the Lung Cancer Registry. Also, we collected data from seven Public Health Institutes, one for each district to analyze incidence and mortality rates. The primary objective of the study was to determine the impact of demographic and clinical pathological characteristics of patients on overall survival. The secondary objective was to analyze the incidence and mortality of lung cancer in the region of Vojvodina. Incidence and mortality rates were directly age-standardized to the World and Europe Standard Population. Results: A total of 15072 patients were eligible for the analysis, 10413 (69.1%) males and 4659 (30.9%) females. The most of the patients were current smokers (62.9% males vs 63.3% females), stage IV (47.7% males vs 46.9% females), ECOG performance status 1 (78.5% males vs 79.0% females). One-year survival rate for the patients with stage IV squamous carcinoma was 20.5% males vs 27.2% females, adenocarcinoma 18.0% males vs 22.9% females and small-cell carcinoma 10.6% males vs 17.8% females. Three-year survival rate for all stages of squamous carcinoma was 12.7%, adenocarcinoma 11.8% and small-cell carcinoma 2.9%. Five-year survival rate for all stages of squamous carcinoma was 7.4%, adenocarcinoma 6.8% and small-cell carcinoma 1.9%. There was statistically significant difference in survival time by gender in subtypes of adenocarcinoma (p = 0.000), squamous cell carcinoma (p = 0.000) and small-cell carcinoma (p = 0.001). Analysis showed significant difference in survival by age (p = 0.000), cancer type (p = 0.000), stage of the disease (p = 0.000), ECOG performance status (p = 0.000) and smoking status (p = 0.001). Incidence (ASR-W) was 65.4/100000 for males and 21.7/100000 for females. Mortality (ASR-W) was 67.8/100000 for males and 20.9/100000 for females. Conclusions: Northern Serbian Province of Vojvodina is one of the regions with the highest incidence and mortality of lung cancer and overall survival is low. Determining the impact of the most important demographic and tumor characteristics on lung cancer patients’ survival, as well as incidence and mortality rates define the parameters necessary for adequate planning of activities and strategies for improving the prevention, diagnosis and treatment of patients in Vojvodina.

Sustainable Tourism in Protected Areas—The Case of the Vršac Mountains Outstanding Natural Landscape, Vojvodina Province (Northern Serbia)

The sustainable development of tourism in protected areas and the planning of its development is extremely important for mountain regions. The local population and tourists have a very important role in this process. Therefore, surveys of the local population and visitor satisfaction represent the basis of this research. The Vršac Mountains Outstanding Natural Landscape (ONL) could represent a significant destination for sustainable tourism. This mountainous area is characterized by a favorable geographical position, a diversity of natural and social factors, rare flora and fauna, and the rich ethno-social heritage of the local population. It is in a very favorable geographical position, and the proximity of the big cities Serbia and Romania, as well as many other factors, are important for tourism development in this area. A quantitative methodology was used for the purposes of this paper during our research. The purpose of this research was to investigate the influence of tourism development on the satisfaction of residents and visitors of the ONL by applying a survey technique, with the help of a questionnaire as a research instrument. A total of 1419 respondents were surveyed (789 residents and 630 visitors). The research results show that the ecological and socio-cultural dimensions of sustainability have the greatest importance for the respondents, and that these two dimensions of sustainability have the greatest impact on sustainable tourism in this protected area. Our main research hypothesis, which states that sustainable tourism has a positive impact on the satisfaction of residents and visitors, is fully confirmed. These data could be significant for tourism planning and the management of protected areas.

Decade of lung cancer in Serbia: tobacco abuse and gender differences.

Lung cancer (LC) is one of the most frequently diagnosed cancers and the leading cause of cancer mortality worldwide. The aim of this study was to get a comprehensive insight into the epidemiology of LC among patients in Vojvodina, the Northern Serbian region, during the ten-year period. This retrospective study was performed using LC hospital registry data of the Institute for Pulmonary Diseases of Vojvodina (IPBV) from 2011 to 2020. All patients reported in the registry with a place of residence in Vojvodina were included in this study. The data used in this research were: date of diagnosis, gender, age at diagnosis, place of residence, smoking habits at diagnosis, the intensity of smoking (pack/years), ECOG performance (0-5), histological cancer type, TNM classification and disease stage. A total of 12,055 LC patients were included, 69.6% of whom were male. The percentage of female LC patients significantly increased, from 26.9% in 2011 to 35.9% in 2020 (p<0.001). Non-small cell lung cancer (NSCLC) was diagnosed in 80.8% of patients, while 15.4% of patients had small cell lung cancer (SCLC). The most common histological type was adenocarcinoma (41.9%), followed by squamous cell carcinoma (30.0%) and SCLC (15.4%). The number of diagnosed LC patients in the Northern Serbian region increased over the past decade and is significantly higher in females. There was a strong correlation between smoking habits and LC in both genders. Our results also indicate the importance of introducing and promoting LC screening programs for all risk populations, particularly current and ex-smokers of younger age.