Source: Iyasu S, Randall LL, Welty TK, et al. Risk factors for sudden infant death syndrome among Northern Plains Indians. JAMA. 2002;288:2717–2724.Infant mortality among American Indian infants is consistently above the US national average, with Sudden Infant Death Syndrome (SIDS) the leading cause of infant deaths in the Plains Indian region of North Dakota, South Dakota, Nebraska, and Iowa. SIDS is defined as the sudden death of an infant younger than 1 year, unexplained through case investigation, including a complete autopsy, examination of the death scene, and a review of the infant’s clinical history. The SIDS rate was 1.5 per 1,000 live birth for American Indian infants and 0.7 per 1,000 live births for all races combined nationally.1 This multi-institutional study was undertaken to determine prenatal and postnatal risk factors for SIDS among American Indians. A population-based case control study among American Indians in the Plains area from December 1992 to November 1996 included 33 SIDS infants and 66 matched living controls. A standardized parental interview, medical record abstraction, autopsy protocol, and infant death review were utilized. Assignment of the SIDS diagnosis meant that there was no evidence of abuse or neglect. The number of case and control infants who were placed prone to sleep, who shared a bed with parents, or whose mothers smoked during pregnancy were similar.The mean age at death of the SIDS infants was 109 days; 51.5% were male and 64.7% died during the autumn and winter months. Adverse maternal behaviors among all infants included smoking during the 3 months prior to pregnancy and smoking throughout all 3 trimesters (the difference between cases and controls was not significant), use of alcohol during the 3 months prior to pregnancy, and alcohol use during each trimester (the difference between cases and controls was significant in the first trimester only). Binge drinking was more common among case than control mothers, with the difference significant for the first trimester (46.7% versus 19.4%). Case mothers consumed an average of 4.5 drinks per day versus 4.1 for control mothers on the days that they drank (P<.08). The percentage of infants put to sleep on their stomachs in the 2 weeks prior to death did not differ between case and control infants. Infants who had 2 or more layers of clothing or covers were at an increased risk for SIDS (unadjusted OR, 3.9; 95% CI, 1.4–10.9). Infants whose homes were visited by a Public Health Nurse (PHN) had a significantly lower risk for SIDS than those who were never visited (adjusted OR, 0.2; 95% CI, 0.1–0.8). This study identifies 1 factor that is and 2 factors that may be amenable to public health action and further research in the prevention of SIDS: 1) visits by PHNs, 2) periconceptional maternal alcohol drinking and first trimester binge drinking, and 3) infant layers of clothing.There are a few published studies reporting a relationship between maternal alcohol use and SIDS, but no reports of a correlation between maternal prenatal alcohol use and the risk of SIDS. Excess thermal insulation for a given room temperature has been previously associated with an increased risk of SIDS, particularly in the presence of coexisting viral illness and prone sleep position.2,3 In a previous report, bed sharing and parental fatigue were thought to be associated with SIDS but that study did not indicate a significant relationship between bed sharing and cigarette smoking or alcohol consumption and SIDS.4Simple social justice requires a response to the finding of such excess mortality to determine if it is, in fact, amenable to public health interventions in this population group.