The Caicedo Tuffs is a recently mapped Paleogene volcanic arc unit in the northern Andes, which provides insight into the magmatism of northwestern South America following its collision with the Caribbean-Colombian Oceanic Plateau (CCOP) in the latest Cretaceous. New regional geological mapping, igneous petrography, whole-rock and pyroxene geochemistry, and zircon U-Pb dating are provided for the northern sector of the eastern flank of the Western Cordillera of Colombia (Antioquia). These data reveal that the Caicedo Tuffs unit is predominantly composed of primary volcaniclastic deposits (tuff to breccia) that record mafic subaqueous volcanism and limited orogenic building shortly after collision of the CCOP. The geochemistry of these deposits includes major element characteristics and immobile trace element patterns that are typical of boninites. Zircons from these igneous rocks constrain a crystallization age of ca. 57 Ma, with meso-Proterozoic to Jurassic inherited zircons most likely reflecting continental recycling by turbidites in the subduction zone. The boninitic affinity of the Caicedo Tuffs and existing regional igneous and tectonic constraints can be explained by resuming of subduction and/or sinking of an older oceanic slab along northern South America following collision of the CCOP with South America. The boninitic, primary volcaniclastic deposits of the Caicedo Tuffs are crosscut by basaltic-gabbroic sills and dykes with oceanic plateau-like geochemical affinities, which lack evidence for hydrous melting and are compositionally similar to igneous rocks of the CCOP. These intrusions are interpreted to reflect decompression melting of plume-related mantle inherited during the collision of the CCOP with South America or slab detachment. The occurrence of oceanic plateau-like intrusions in a Paleocene volcanic arc casts doubt on the origin of other oceanic plateau sequences of the Western Cordillera, which are generally attributed to the Cretaceous CCOP. The Caicedo Tuffs is a unique boninite unit of which the detailed spatiotemporal extent and petrogenesis remain to be constrained, but that can provide valuable insight into tectono-magmatic processes during oceanic plateau-continent collision.