North Indian Adults Research Articles

To Establish Cephalometric Floating Norms as a Guide toward Harmonious Cranial Individual Pattern among North Indian Adults

Abstract Introduction Floating norms put us at ease while diagnosing and establishing a treatment plan for an individual with abnormal skeletal pattern. It uses the variability of the associations among appropriate cephalometric variables and later on the basis of a regression model by combination of both skeletal parameters which are sagittal and vertical and construct a harmony box which make diagnosis straightforward. This study aims to establish floating cephalometric norms for the describing individual craniofacial skeletal pattern among North Indian Adults as an additional diagnostic tool for orthodontic treatment planning. Materials and Methods The study includes North Indian adults in age range of 17 to 25 years. A total of 30 patients were selected and were subjected to cephalometric evaluation. Various angular measurements viz., SNB (sella-nasion-point B), NL-NSL (maxillary line-nasion sella line), ML-NSL (mandibular line-nasion sella line), N–S–Ba (nasion-sella-basion), SNA (sella-nasion-point A), and ML-NL (mandibular line-maxillary line) were considered for designing harmony box for North Indian adults. Results The results of the study were subjected to various statistical analyses. SNB served as the independent variable and NL-NSL, NSBa, ML-NSL, ML-NL, and SNA were made the dependent variable due to lesser R2 values in multiple regression analysis. Correlation between some of the variables, such as (SNA–SNB, ML-NSL–NL-NSL, and ML-NSL–ML-NL), in the present North Indian sample showed positive correlation among each other and were statistically significant (p = 0.000). When compared with the other similar studies done previously, least variability was seen with the Segner study and maximum variability was seen with Thilander’s study. Conclusion The analysis of the individual craniofacial pattern by means of floating norms appears to provide a helpful method in determining the parameters responsible for the skeletal disharmony, thus representing a viable option for additional diagnostic tool in orthodontic and orthopaedic/surgical treatment planning.

A Cross Sectional Study on Middle Finger Tip Pinch, Ring Finger Tip Pinch, Little Finger Tip Pinch Strengths : The Correlations with Anthropometric Variables in North Indian Population

Introduction: Pinch strength in addition to handgrip strength is considered an important factor in the assessment of proper hand muscle function. Various parameters like nutritional status, physical activities and muscle pathologies can affect the overall gripping capabilities of the fingers .The unique abilities of opposition in human hand is because of the distinct articular surfaces in the miniature bones and intrinsic muscles of the hand. Due to fine neuromuscular coordination and sensory perception in the digits, firm grasping abilities and in the hand pinches have developed. These grasps can be very useful for sensory and motor capabilities of the hand specially in sports like cricket, baseball and volleyball. AIM: To generate data for middle finger tip pinch, ring finger tip pinch, little finger tip pinch strengths and to evaluate their correlations with other anthropometric indices. Materials and Methods: Four hundred and fifty healthy young adult individuals were selected for the study. A pinch gauze was used to measure pinch grip strengths in both the sides. Pearson’s correlation test and independent t-tests were used. SPSS Version 20 was used for statistical analysis. Result: Mean age of the population was 22 years and all the subjects were males. Pinch grip strength in all the pinches were found to be greater in dominant side than non dominant side (p<0.001). There was significant association between middle finger tip pinch and anthropometric indices. No statistically significant correlation of little finger tip pinch with waist circumference, waist to hip ratio and BMI was observed. Conclusion: The analysis provides normative data for pinch grip strengths and their correlation with other anthropometric indices in adult North Indian population.

Correlation of Serum Magnesium with Insulin Resistance in North Indian Adult Population.

Globalization has lead to such lifestyle changes which have produced increase in incidence and prevalence of Type 2 Diabetes Mellitus (T2DM). Magnesium is found to have some role in glucose metabolism. The aim of this study was to investigate the relationship between serum magnesium levels with insulin resistance in apparently healthy adults. The objective of our study was to evaluate correlation of serum magnesium with fasting blood sugar, insulin level and Homeostasis model assessment-insulin resistance (HOMA-IR) index (indicator of insulin resistance) on the basis of the hypothesis that subjects with hypomagnesaemia are more prone to develop hyperglycemia and insulin resistance. The study was a cross-sectional study which was population based. Total 130 apparently healthy adults of age between 25-65 years, were recruited with prior ethical approval and written informed consent. Serum magnesium was found to be negatively correlated with fasting blood sugar (FBS), insulin level and HOMA-IR. Co-relation of magnesium with FBS (r = -0.55, p<0.0001), insulin (r = -0.45, p< 0.0001) and HOMA-IR (r = -0.52, p<0.0001) was significant. As per findings it was concluded that serum magnesium was found to have significant negative correlation with fasting blood sugar (FBS), insulin and HOMA-IR, thus hypomagnesaemia can be suggested to be one of the important predictor of type 2 diabetes mellitus.

Metabolic Bone Profile of Healthy Adult North Indian Population from Chandigarh Urban Bone Epidemiological Study (CUBES).

We aimed to estimate metabolic bone profile in a large cohort of healthy, adult Indian population to generate reference standards of serum calcium, phosphate and alkaline phosphatase (ALP), 25 (OH) Vitamin D and iPTH, and also to find out the prevalence of Vitamin D deficiency in healthy population. Apparently healthy people in the age group of 20-80years, residing in the union territory of Chandigarh were chosen. Fasting samples for serum calcium, phosphate, albumin, alkaline phosphatase (ALP), 25 (OH) D and iPTH were collected and were processed on the same day. We recruited 930 healthy subjects from different subsectors of Chandigarh. Final analysis was done for 915 subjects. Out of this, 530 (58%) were women and 385 (42%) were men. The study participants were divided into two groups, less than and more than 50years for the men and pre and post-menopausal for the women. The serum calcium, phosphate, ALP and iPTH were significantly higher in the post-menopausal women compared to the pre-menopausal women. The median plasma 25 (OH) D in men and women was 12.5ng/mL and 14.3ng/mL, respectively. 25 (OH) D deficiency was seen in 65.4% of individuals. 25 (OH) D levels co-related negatively with iPTH levels (r = - 0.4, p < 0.0001), and showed an increasing trend with age. We have thus presented metabolic bone profile of healthy, adult north Indian population. These reference values can be used for diagnosis and monitoring of various MBDs. Vitamin D deficiency is still rampant in our population in spite of increasing awareness.

Comparison of outcomes in malignant vs. non-malignant ischemic priapism: 12-year experience from a tertiary center.

Data on outcome of patients with ischemic priapism (IP) due to malignant causes are scant. In this study, we compared outcome of patients with malignant vs. non-malignant IP in adult North Indian men. We analyzed medical records of patients with IP who presented to a large tertiary care referral center from August 2005 to July 2017. Data of 71 patients were analyzed. The median age was 30 years (range 17-65). The average duration of symptoms was 4.39 days (range 1-10). Most common etiology was idiopathic in 29 (40.84%), chronic myeloid leukemia (CML) in 24 (33.80%), and drug-induced in 15 patients. Thirty-eight patients underwent distal shunts, while nine patients underwent proximal shunt procedure. Men with malignant priapism (CML) had significantly lower success rates with interventions, prolonged hospital stay, and higher complications (p<0.05). Most complications after shunt surgery were minor (Clavein grade 1 and 2). After shunt surgery, bleeding at shunt site was observed in 14 cases, and wound infection developed in five patients. Prevalence of erectile dysfunction in patients at follow-up was high. Men with malignant priapism (CML) had significantly lower success rates with interventions, prolonged hospital stay, and higher complications than men with non-malignant priapism.

Successful Treatment of Chromobacterium violaceum in a North Indian Adult: A Case Report with Review of Literature

Successful Treatment of Chromobacterium violaceum in a North Indian Adult: A Case Report with Review of Literature

Comparison of Rockport one-mile walk test and McArdle step test for the prediction of VO2max

Background: There are various field tests to predict VO2max. The Rockport one-mile walk test and McArdle step test are among them, which are easy to administer and give good result. The purpose of this study was to see the differences in the result of VO2max predicted by Rockport one-mile walk test and McArdle step test in the adult North Indian population. Methodology: A total of sixty college/university students from North India, between the age group of 18 and 25 years, were divided into two equal groups of thirty each. Group A performed Rockport one-mile walk test and Group B performed McArdle step test. Results and Analysis: The mean age (years), height (cm), weight (kg), and VO2max (ml/kg/min) of Group A were 19.73 (±1.34), 172.37 (±8.52), 63.23 (±11.01), and 55.47 (±3.73), respectively, whereas the mean age (years), height (cm), weight (kg), and VO2max (ml/kg/min) of Group B were 19.30 (±1.02), 174.17 (±7.56), 70.03 (±7.11), and 53.12 (±9.37), respectively. T-test applied between both groups, and there is no statistically significant difference found in age (0.164), height (0.392), weight (0.006), and VO2max (0.206) between both groups. Conclusion: This study has concluded that there is no difference between the Rockport one-mile walk test and McArdle step test for the prediction of VO2max. Hence, we can use any of the tests, either Rockport one-mile walk or McArdle step test, for calculating VO2max in any individuals.

A STUDY ON CEPHALIC INDEX OF ADULT NORTH INDIAN POPULATION

Introduction: Cephalic index is the percentage of head breadth to head length. The index is calculated from measurement of the diameters of head (head length and head breadth). When applied to living individuals it is known as cephalic index, and when referring to dry skulls, the cranial index. This index is used as a useful anthropological tool for analysis of racial and sexual differences in a population. The present study was done to find out Cephalic Index and to study sexual dimorphism in adult North Indian population. Objective of the study was to calculate the cephalic index and to find out that the present study group belongs to which category in the classification of skull based on cephalic index and to study the sexual dimorphism in respect to cephalic index. Material &amp; Methods: The present study comprised of 200 medical students of age group between 18 yrs. to 25 yrs. of S.N. Medical College, Agra, not having any significant disease or deformity that could have affected the general or the bony growth. Two anthropometric parameters; head length and head breadth were recorded in centimeters by using spreading caliper. With these recorded data, cephalic index was calculated for males and females separately as well as combined. Results: Mean Cephalic Index was significantly higher (p=0.03124) in females (79.350 ± 5.7157) as compared to males (77.715 ± 4.9102). Conclusion: There was a statistically significant difference in the mean of the cephalic indices of male and female students (p=0.03124). The mean cephalic index of combined population in this study was 78.533 ± 5.3776 which states that the dominant head shape among North Indians is Mesaticephalic.

To Evaluate the Severity, Distribution of Occlusal Tooth Wear and its Correlation with Bite Force in Young North Indian Adults.

Aim:To determine the severity and distribution of occlusal tooth wear among young North Indian adults and to evaluate the correlation of occlusal tooth wear with bite force.Materials and Methods:A total of 164 subjects were enrolled in the present study. Inclusion criteria included subjects with age range of 25-40 years having a full complement of natural dentition (excluding third molars), with no history of orthodontic treatment, FPD and trauma. Maxillary and mandibular casts of each subject were taken. Tooth wear score of anterior and posterior teeth of both the arches was calculated using a five-point (0 to 4) ordinal scoring system. The calculated tooth wear scores were then compared with data concerning age, sex, number of daily meals, vegetarian/non-vegetarian diet, Group function/Canine guided occlusion and bite force. Nonparametric (Mann-Whitney) test was used to determine the relationship between various factors and occlusal tooth wear. Spearman’s correlation coefficient was used to determine the correlation between tooth wear and bite force.Results:After applying statistical analysis to the data collected, total tooth wear score of the whole sample was 30.07 ± 6.39. Anterior teeth had significantly higher wear score than posteriors (P < 0.01). Males showed significantly higher (P < 0.001) tooth wear in both arches factors such as bite force and age showed significant correlation with tooth wear (P=0.000), however, the number of meals taken per day did not show any significant correlation. Higher tooth wear loss was seen in non vegetarian dietary pattern but it was statistically insignificant. It was also found that Group function occlusion showed significantly higher mean tooth wear loss 45.76 ± 9.19 as compared to Canine guided occlusion 26.37 ± 10.68 (P=0.000).

Microbial etiology in hospitalized North Indian adults with community-acquired pneumonia.

Background:There is a paucity of literature regarding the microbial etiology of community-acquired pneumonia (CAP) in India. The current study was aimed to study the microbial etiology of hospitalized adults with CAP.Methods:The study was conducted in a 700-bedded North Indian hospital. Consecutive adults admitted with CAP over a period of 2 years from 2013 to 2015 were recruited for the study, and apart from clinical evaluation underwent various microbiological studies in the form of blood culture, sputum culture, urinary antigen for pneumococcus and Legionella, serology for Mycoplasma and Chlamydia and real-time reverse transcriptase polymerase chain reaction for influenza viruses. Radiographic studies were performed in all patients and repeated as required. The patients were treated with standard antibiotic/antiviral therapy and outcomes were recorded.Results:A total of 225 patients (median age: 59 years) were enrolled. Streptococcus pneumoniae was the most common organism found (30.5%), followed by Legionella pneumophila (17.5%), influenza viruses (15.4%), Mycoplasma pneumoniae (7.2%), Chlamydia pneumonia (5.5%), Mycobacterium tuberculosis (4.8%), Klebsiella pneumoniae (4.8%), methicillin-resistant Staphylococcus aureus (3.5%), Pseudomonas aeruginosa (3.1%), methicillin-sensitive S. aureus (1.7%), and Acinetobacter sp. (0.8%) with 4% of patients having multiple pathogens etiologies. High Pneumonia Severity Index score correlated with the severity and outcome of the CAP but was not predictive of any definite etiological pathogen. In-hospital mortality was 8%.Conclusion:Streptococcus pneumoniae, Legionella, and influenza constitute the most common etiological agents for north Indian adults with CAP requiring hospitalization. Appropriate antibiotic therapy and preventive strategies such as influenza and pneumococcal vaccination need to be considered in appropriate groups.

Characterization of Anemia in Type 2 Diabetes Mellitus Patient: A Study in Rural North Indian Adults

Characterization of Anemia in Type 2 Diabetes Mellitus Patient: A Study in Rural North Indian Adults

Study of renal artery in adult North Indian population: A CT study

Study of renal artery in adult North Indian population: A CT study

A morphometric and comparative study of foramen magnum in North Indian population

IntroductionCranial base, especially the foramen magnum (FM), is of particular interest for anatomists, anthropologists, and neurosurgeons due to its complex relations with vital structures in this region. It is important as well as mandatory to have knowledge about its normal and variant dimensions for better transcondylar surgical approach. Materials and methodsVarious diameters of foramen magnum of 120 adult North Indian dry skulls of unknown age and gender were examined using an electronic digital sliding caliper. ResultsThe commonest FM shape was oval and rarest was irregular. The mean antero-posterior (AP) and transverse diameters were 34.68±2.88mm and 27.24±2.4mm, respectively. The mean surface area was 757.09±115.82mm2. The mean Foramen Magnum Index (FMI) was 78.71±5.94. DiscussionResults provide a baseline data for anatomists and important information for neurosurgeons to approach the cranial base with maximum safety and minimum mortality and morbidity.

Morphometric Study of Nasal Bone and Piriform Aperture in Human Dry Skull of Indian Origin.

Nasal bone and piriform aperture shows racial and geographical differences because of variable climate. The aim of this study was to evaluate the dimensions (maximal width and length), the size and the shape of the piriform aperture (PA) and their sexual dimorphism in North Indian adult. In this observational study, dimension of piriform aperture and nasal bone were measured using digital vernier caliper after assessing landmarks around the piriform aperture on the norma frontalis in Frankfurt plane in 40 skull of Indian orgin. The mean width of the piriform aperture was 24.9±1.59 mm in males and 22.77±1.57 mm in females, the mean length was 29.57±3.28mm in females and 31.16±3.58mm in males. The difference between males and females was significant, and our data correlates well with the previously data acquired from humans skulls. Most of North Indian skulls have platyrhine type of piriform aperture (triangular to oval shape with pyriform aperture index of 0.79). Mean length and width of nasal bone were 17.58±2.47mm and 12.1±0.97mm respectively without sexual. Shape and size analysis of the piriform aperture and nasal bone showed the existence of a significant sexual dimorphism. These results encourage us to go further with functional and imaging correlations. This study will also be helpful in forensic research and anthropology.

Prediction equations for diffusing capacity (transfer factor) of lung for North Indians.

Background:Prediction equations for diffusing capacity of lung for carbon monoxide (DLCO), alveolar volume (VA), and DLCO/VA using the current standardization guidelines are not available for Indian population. The present study was carried out to develop equations for these parameters for North Indian adults and examine the ethnic diversity in predictions.Materials and Methods:DLCO was measured by single-breath technique and VA by single-breath helium dilution using standardized methodology in 357 (258 males, 99 females) normal nonsmoker adult North Indians and DLCO/VA was computed. The subjects were randomized into training and test datasets for development of prediction equations by multiple linear regressions and for validation, respectively.Results:For males, the following equations were developed: DLCO, −7.813 + 0.318 × ht −0.624 × age + 0.00552 × age2; VA, −8.152 + 0.087 × ht −0.019 × wt; DLCO/VA, 7.315 − 0.037 × age. For females, the equations were: DLCO, −44.15 + 0.449 × ht −0.099 × age; VA, −6.893 + 0.068 × ht. A statistically acceptable prediction equation was not obtained for DLCO/VA in females. It was therefore computed from predicted DLCO and predicted VA. All equations were internally valid. Predictions of DLCO by Indian equations were lower than most Caucasian predictions in both males and females and greater than the Chinese predictions for males.Conclusion:This study has developed validated prediction equations for DLCO, VA, and DLCO/VA in North Indians. Substantial ethnic diversity exists in predictions for DLCO and VA with Caucasian equations generally yielding higher values than the Indian or Chinese equations. However, DLCO/VA predicted by the Indian equations is slightly higher than that by other equations.

Correlation between Age, Gender, Waist-Hip Ratio and Intra Ocular Pressure in Adult North Indian Population.

Intraocular pressure (IOP) is affected by various systemic and local factors. The significance of studying the factors affecting IOP is because of its association with potentially blinding condition known as glaucoma. Present study was conducted with the aim to find out the correlation between gender, age, Waist-Hip Ratio (WHR) and IOP. The study included 300 healthy individuals between 40-79years of age. The subjects were divided into 2 categories according to gender i.e., male and female. The subjects were divided into 4 categories according to age i.e., 40-49years, 50-59years, 60-69years and 70-79years. The subjects were divided into two groups according to Waist-hip ratio (WHR) as per WHO guidelines: WHR <0.9 and WHR >0.9 in males and WHR <0.85 and WHR >0.85 in females. IOP was recorded in each group using Goldmann Applanation tonometer and statistical comparisons were made to find correlation between gender, age, Waist-hip ratio and IOP. There was no statistically significant difference between IOP of males and females (p=0.235). The age and IOP were positively correlated with each other i.e., IOP increases with increasing age (r=0.511, p<0.001). Higher WHR is associated with significantly higher IOP in both the genders (males r =0.644, p<0.001; females r=0.794, p<0.001). There is no significant difference in IOP amongst males and females. Increasing age and higher WHR are risk factors for raised IOP.

Correlation of gender and age with serum adipokines level in north indian adults

Objective: There are two forms of adipose tissue, brown adipose tissue (BAT) and white adipose tissue (WAT). Distribution of adipose tissue differs in different gender and different age group. Adipose tissue expresses various secretary proteins, including leptin and adiponectin, collectively called adipokines. The purpose of this study to elucidated the correlation of serum leptin, serum adiponectin levels with age and gender in north Indian population. Materials and Methods: 100 subjects (55 male, 45 female) aged between 18?25 yrs were included in the study. Blood sample were taken after overnight fasting for biochemical assay. Serums were separated by centrifugation method. Serum leptin and serum adiponectin were analyzed by using RayBio ELISA Kit. Result: The serum leptin (pg) was significantly (p=0.001) higher among female (428.28±83.06) subjects compared with males (365.42±102.56). Similarly, serum adiponectin (pg) level was also significantly (p=0.02) higher among females (5313.15±1151.12) than males (4794.72±1078.38). The age was mildly and negatively correlated with Serum adiponectin (r= -0.317, p=0.001) and had no correlation with serum leptin levels. Conclusion: Serum adipokines levels in young north Indian adults are influenced by gender and age of subjects, suggests that female subject, relative to the males, are at increased risk for obesity-related metabolic co-morbidities.DOI: http://dx.doi.org/10.3126/ajms.v6i5.11862 Asian Journal of Medical Sciences Vol.6(5) 2015 9-11

MORPHOMETRIC MEASUREMENT OF MENTAL FORAMEN IN DRY HUMAN MANDIBLE IN NORTH INDIAN POPULATION

Background: The mental foramen is one of the two holes (“foramina”) located on the anterior surface of the mandible. It permits passage of the mental nerve and vessels. The mental foramen descends slightly in edentulous individuals. Methods: The present study was carried out in the department of anatomy on 70 Adult North Indian dry Mandibles of unknown age and sex which were obtained from the osteology section of Integral Institute of Medical Sciences and Research & King George medical university. The Mandibles were observed macroscopically for the presence of mental foramen. Results: In our study we observed that the oval shape of mental foramen was 87.1% on right side and 88.6% on left side. Round mental foramen was observed to be 12.9% on the right side and 11.4% on left side. The Position of Mental foramen in relation to borders left side were found Central (87.1%), upper border (7.1%), lower side (5.7%) and right side Central (85.7%) , upper border (10%) and lower side (4.3%). Conclusions: Knowledge of the mental foramen and it’s variation in different population is essential for dentists, orthopedicians and anatomists. A future prospect of interest lies in their possible contribution to the maxillofacial anthropologic characteristic identification for different population and races.

Morphometric Study of Metopic suture in Adult North Indian skulls

Background: A suture is a type of fibrous joint which only occurs in the skull or cranium. They are bound together by sharpey”s fibre. A tiny amount of movement is permitted at sutures, which contributes to the compliance and elasticity of the skull. Sutures are junctions or line of articulation between adjacent bones of skull.Methods: The present study was carried out in the department of anatomy on Adult North Indian 100 Skulls of unknown age and sex which were obtained from the osteology section of Integral Institute of Medical Sciences and Research & King George medical university. 20 damaged and diseased skulls were excluded from the study and 80 skulls were observed.Results: In our study we observed 66 (82.50%) skulls who had neither complete nor incomplete metopic suture. 14 skulls (17.5%) had metopic suture either in the form of complete or incomplete. Complete metopic suture was found in two skulls (2.50%) and incomplete suture was observed in twelve skulls (15%). Among the incomplete metopic sutures, the incidence of linear incomplete metopic suture was 9/80 (11.25%), inverted 'U' shaped incomplete metopic suture was 1/80 (1.25%) and 'V' shaped incomplete suture was 2/80 (2.5%).Conclusions: Knowledge regarding persistent metopic suture is essential in studying the radiographs to avoid misinterpretation as fractures. It is also useful in evaluating various medico legal cases.

Morphometric analysis and anatomical variations of infraorbital foramen: A study in adult North Indian population

Various studies have been conducted on morphometric variations of infraorbital foramen to provide data to surgeons for nerve block in infraorbital region. This study aims to analyse the anatomical variations by comparing various morphometric measurements of infraorbital foramen in dry skulls of adult North Indian population. This study becomes relevant in the present study group as very scant data is available about the variations and morphometric measurements in Indian population. The data thus collected can be standardized and become useful for the surgeons working in this area of face. The study was conducted on 75 dry adult human skulls, which were a part of Department of Anatomy, used for teaching purposes in medical colleges. Straight distance of the Infraorbital foramen from the infraorbital rim, supraorbital foramen and sagittal plane was measured. The position of the infraorbital foramen was determined in relation to maxillary teeth and supraorbital foramen. The data thus obtained was analysed. The distance of infraorbital foramen from infraorbital rim, supraorbital foramen, sagittal plane in the present study was found to be 6.71 ± 1.11 mm, 42.02 ± 4.31 mm and 31.94 ± 4.88 mm respectively. The position of infraorbital foramen was lateral in relation to supraorbital foramen (in 88% of cases). Infraorbital foramen was above the 1st premolar tooth in most of the cases. Accessory infraorbital foramen was found in 11.2% cases (double foramen). The data thus obtained will perhaps be helpful to the surgeons in identifying the extent of the operative field thereby reducing procedural risks.