Thomas Wolfe (Figure (Figure11), regarded as one of the greatest novelists of the 20th century, died in 1938 at the age of 37 of tuberculosis (TB) of the brain. Other great literary figures afflicted with TB include John Keats, Percy Shelley, Elizabeth Barrett Browning, Robert Louis Stevenson, Henry David Thoreau, Emily and Charlotte Bronte, Anton Chekov, and F. Scott Fitzgerald. TB was called the “artist's disease” and was linked with creativity and the bohemian life. The TB sufferer was a wanderer in search of a healthy place, and the disease provided people with a reason to travel. Figure 1 Thomas Wolfe in his 30s. Photo: The Thomas Wolfe Collection, Pack Memorial Public Library, Asheville, NC. In 1900, the year of Wolfe's birth, TB was the most dreaded disease throughout the world and was the leading cause of death in the United States. The “climatic theory” of treating lung disease, which originated in Germany and Switzerland, proposed that altitude, atmosphere, and the climate of cool mountain air would help cure the disease of TB, also called the White Plague. Wolfe's hometown of Asheville, North Carolina—which offered the best combination of altitude, atmosphere, and climate—had become a world center for the treatment of TB. Because of this, thousands of TB victims came to Asheville, including George Vanderbilt and E. W. Grove, who contributed to the building of the Biltmore House and the Grove Park Inn, respectively. At the end of the 19th century, it was reported that there were 25 TB specialists in Asheville; many came first as patients to be treated for TB. Between 1900 and 1930, over 25 TB sanitariums were established, but most patients stayed in boarding houses with lower rates of $5 to $15 per week. The houses, which had open air sleeping porches as a necessity, were operated solely for the care of TB patients. The number of boarding houses rose from 55 in 1900 to 137 in 1910. Thomas Wolfe's mother, Julia, had a keen business sense and in 1906 purchased a 29-room boarding house in downtown Asheville called the Old Kentucky Home located near the family home (Figure (Figure22). Young Tom eventually moved into the boarding house permanently for about 10 years. Thus, Tom was probably exposed to TB in his mother's boarding house while growing up. Figure 2 Thomas Wolfe in front of the Old Kentucky Home at 48 Spruce Street, Asheville, NC, about 1906. Photo: North Carolina Collection, University of North Carolina at Chapel Hill, with permission of the Estate of Thomas Wolfe. Wolfe wrote much about diseases, especially TB, in his autobiographical masterpiece, Look Homeward Angel, and it is believed he had a fear of TB, which haunted him and affected his writing long before the discovery of the tubercular lesion in his right lung in 1938. In a letter to his mother in 1920, he wrote about his “heavy cold and the rattling cough” that brought pain to his right lung and a spot of blood on his handkerchief. Tom was only 15 when he enrolled at the University of North Carolina in Chapel Hill. He went there alone with no connections or close friends. Described as a “green freshman,” obscure and lonely, he would become a prominent and popular campus figure by his junior year. Outside the classroom, he pursued numerous activities and “joined everything.” He was editor of the college newspaper, The Tar Heel; wrote stories, plays, and poems for the university magazine; and was associate editor of the college annual, Yackety Yak. Active in formal debate, Wolfe later joined the Carolina Playmakers, and in 1919, his one-act play, “The Return of Buck Gavin,” was given its premier, with the author appearing as the mountain outlaw of the title. He was selected to the Golden Fleece honor society and was a member of Pi Kappa Phi social fraternity at the University of North Carolina (Figure (Figure33). At the end of his senior yearbook entry, the following quote appeared: “He can do more between 8:25 and 8:30 than the rest of us can do all day, and it is no wonder that he is classed as a ‘genius.’” Figure 3 Thomas Wolfe (center) and two other students at the Pi Kappa Phi fraternity house. Photo: North Carolina Collection, University of North Carolina at Chapel Hill. After graduation, Tom enrolled at Harvard and eventually ended up teaching and writing in New York City. He made several trips to Europe. His first novel, Look Homeward Angel, was published in 1929. Of Time and the River followed in 1935 (Figure (Figure44). Figure 4 Working on the manuscript for Of Time and the River in his Brooklyn apartment in 1935. Photo: The Thomas Wolfe Collection, Pack Memorial Public Library, Asheville, NC.