AbstractRecent studies demonstrated the existence of a conspicuous atmospheric combination mode (C-mode) originating from nonlinear interactions between El Niño–Southern Oscillation (ENSO) and the Pacific warm pool annual cycle (AC). Here we find that the C-mode exhibits prominent decadal amplitude variations during the ENSO decaying boreal spring season. It is revealed that the Atlantic multidecadal oscillation (AMO) can largely explain this waxing and waning in amplitude. A robust positive correlation between ENSO and the C-mode is detected during a negative AMO phase but not during a positive phase. Similar results can also be found in the relationship of ENSO with 1) the western North Pacific (WNP) anticyclone and 2) spring precipitation over southern China, both of which are closely associated with the C-mode. We suggest that ENSO property changes due to an AMO modulation play a crucial role in determining these decadal shifts. During a positive AMO phase, ENSO events are distinctly weaker than those in an AMO negative phase. In addition, El Niño events concurrent with a positive AMO phase tend to exhibit a westward-shifted sea surface temperature (SST) anomaly pattern. These SST characteristics during the positive AMO phase are both not conducive to the development of the meridionally asymmetric C-mode atmospheric circulation pattern and thus reduce the ENSO/C-mode correlation on decadal time scales. These observations can be realistically reproduced by a coupled general circulation model (CGCM) experiment in which North Atlantic SSTs are nudged to reproduce a 50-yr sinusoidally varying AMO evolution. Our conclusion carries important implications for understanding seasonally modulated ENSO dynamics and multiscale climate impacts over East Asia.