Community Climate System Model (CCSM3) sensitivity experiments are performed to investigate the impact of past wetland drainage on the hydroclimatology of midwestern United States (MW USA). Coupled land surface and atmospheric components of CCSM3 are used at T85 (∼140 km) horizontal grid mesh size to create four control model experiments. These include: (1) 355 ppm CO2 for year 1990 excluding wetland (present condition), (2) 355 ppm CO2 for 1990 including wetland, (3) 289 ppm CO2 for year 1870 excluding wetland, and (4) 289 ppm CO2 for year 1870 including wetland. The CCSM3 control run for the present condition is validated with high‐resolution North American Regional Reanalysis (NARR) data for the Midwest region. Validation results show that CCSM3 is reasonable in simulating at‐surface incoming solar radiation, net short‐wave radiation, and 2 m air temperature. However, partitioning of net radiation into sensible and latent heat fluxes is imprecise, and summer precipitation is largely underestimated in CCSM3. To remove any biases in CCSM3 output, results from sensitivity experiments are analyzed in terms of difference in monthly climatology. Sensitivity experiment results show significant changes in summer sensible and latent heat fluxes due to wetland drainage. Near‐surface (2 m) air temperature has significantly increased, and convective precipitation has decreased by a small amount (∼50 mm) during the summer. Except for 2 m air temperature which is affected by both greenhouse gas emission–based climate change and wetland drainage over the last century, all other climatic variables are primarily affected by wetland drainage in the region.