Abstract The Las Vegas metropolitan area in Nevada has experienced extensive urban growth since 1950 coincident with regional and local climate change. This study explores the nonstationary flood history of the Las Vegas Wash (LVW) watershed by deconstructing it into its constituent physical drivers. Observations and reanalysis products are used to examine the hydroclimatology, hydrometeorology, and hydrology of flash flooding in the watershed. Annual peak flows have increased nonlinearly over the past seven decades, with an abrupt changepoint detected in the mid-1990s, which is attributed to the implementation of flood conveyance systems rather than changes in land use. The LVW watershed exhibits two pronounced flood seasons, associated with distinct synoptic atmospheric circulations: winter floods linked to inland-penetrating atmospheric rivers and summer floods linked to the North American monsoon. El Niño–Southern Oscillation also plays a role in modulating extreme rainfall and the resultant floods because annual maximum daily rainfall totals positively correlate with El Niño, with Spearman’s correlation coefficient of 0.36 (p value < 0.05). Winter maximum daily rainfall totals have increased since 1950, whereas summer daily rainfall maxima have decreased. The trends in hydrometeorological drivers interact with urbanization to shift flood seasonality toward more frequent winter floods in the LVW watershed. A process-based understanding of the flood hydrology of the watershed also provides insights into flood frequency analysis and flood forecasting.