Normal Transition Research Articles

Superconducting Diode Effect in a Constricted Nanowire

AbstractDue to isotropic superconducting properties and the lack of breaking of inversion symmetry for conventional s‐wave superconductors, a nonreciprocal superconducting diode effect is absent. Recently, a series of superconducting structures, including superconducting superlattice, and quantum‐material‐based superconducting Josephson junction, have exhibited a superconducting diode effect in terms of polarity‐dependent critical current. However, due to complex structures, these composite systems are not able to construct large‐scale integrated superconducting circuits. Here, it is demonstrated that the minimal superconducting electric component‐superconducting nanowire‐based diode with a nonreciprocal transport effect under a perpendicular magnetic field, in which the superconducting to normal metallic phase transition relies on the polarity and amplitude of the bias current. These nanowire diodes can be reliably operated near at all temperatures below the critical temperature, and the rectification efficiency at 2 K can be more than 24%. Moreover, the superconducting nanowire diode is able to rectify both square wave and sine wave signals. Combining the superconducting nanowire‐based diodes and transistors, superconducting nanowires hold the possibility to construct novel low‐dissipation superconducting integrated circuits.

Inference and identity

I argue that beliefs about the identity or distinctness of objects are necessary to explain some normal inferential transitions between thoughts in humans. Worries about vicious regress are not powerful enough to dismantle such an argument. As an upshot, the idea that thinkers “trade on” identity without any corresponding belief remains somewhat mysterious.

Colonic Cancer in Occlusion: A Case Report of 70 Patients Experience of the Visceral Surgery Department at the Moulay Ismail Military Hospital in Meknes, Sidi Mohamed Ben Abdallah University in Fez

Occlusive colon cancer is a serious condition, as it combines two very serious pathologies: cancer and acute intestinal obstruction. Colon cancer is a malignant proliferative neoformation developed at the expense of the colonic wall. Colonic obstruction is defined as the interruption of normal intestinal transit, and represents the mode of revelation in 8 to 29% of colon cancers. Occlusion is the most common complication of colonic cancer, either as a result of the disease or as it progresses, accounting for 15-30% of cases. Occluded colon cancer poses a twofold problem:  On the one hand, occlusion and its potential repercussions, particularly of a general or upstream intestinal nature.  On the other hand, it reveals a late diagnosis most often associated with a locally advanced or metastatic tumour. Our study concerns 70 cases of colonic cancer in occlusion diagnosed and treated in the visceral surgery department of the Moulay Ismail Military Hospital in Meknes, over 5 years from 01 January 2019 to 31 December 2023. The aims of our retrospective study are:  Evaluate the proportion of this complication that is indicative of colonic tumour pathology.  To review the range of surgical and non-surgical techniques available.  To establish guidelines for dealing with this type of complication in order to minimise morbidity and mortality. Our series includes 46 men and 24 women with a sex ratio of 1.9 aged between 35 and 86 years, who presented to the emergency department after an average delay of 07 days with extremes of 03 days and 08 days, with an occlusive syndrome (78.6%), sub-occlusive syndrome (21.4%), abdominal pain (95.7%), transit disorders (82.9%), vomiting (75.7%) and rectal bleeding (72.9%). The clinical examination revealed weight loss in 49 patients (70%); abdominal distension in all our patients (100%); and an empty rectal ampulla in all our patients (100%). All our patients underwent PSA, which revealed colonic NHA in 81.4% of cases, .......

Diffuse to normal ferroelectric transition in Gd-substituted BBTO Aurivillius ceramics

Diffuse to normal ferroelectric transition in Gd-substituted BBTO Aurivillius ceramics

Relationship between Neonatal Cerebral Fuels and Neurosensory Outcomes at 3 Years in Well Babies: Follow-Up of the Glucose in Well Babies (GLOW) Study

Plain Language SummaryIn the Glucose in Well babies and their later Neurodevelopment (GLOWiNg) study, we investigated whether the availability of brain fuels in healthy term babies during the first 5 days after birth was associated with their neurodevelopmental progress at 3 years of age. We had measured plasma glucose, lactate, and beta-hydroxybutyrate concentrations when the children were babies, as these are the most common brain fuels. We used the Ages and Stages questionnaire, which is completed by parents, to assess the child’s development in areas including communication, motor skills (fine and gross), and problem solving.We studied 64 families whose babies were part of the Glucose in Well Babies (GLOW) study in New Zealand. Using both structural equation modelling and linear regression, we found that even though many babies experienced episodes of low plasma glucose concentrations, there was no detectable relationship between these episodes and developmental progress at 3 years of age. We explored other factors, including glucose concentrations, total fuels available, and the duration of low glucose episodes, and found no significant associations. Our results suggest that in healthy term babies, episodes of low glucose concentrations in the first days after birth may be part of the normal metabolic transition after birth and may not have long-term implications for neurodevelopment. However, larger studies using different assessment tools are needed to confirm these findings.

Predicating of Formation Pore Pressures in Tertiary Reservoirs Using Geophysical Wireline Log Data

Changes to certain geophysical characteristics, such as sonic transit time with depth, indicate the pressure system of over-pressured zones. In this study, well-log data is used to investigate the distribution of formation overpressures in the tertiary reservoirs of one Iraqi oil field. Three wells located within the tertiary carbonate reservoir of one Iraqi oil field are of interest in this study. To assess the reservoirs, a petrophysics log analysis was carried out. The reservoir's intervals are the area of interest. The sonic velocity data was used to create a normal compaction trend line, and the overpressure zones were identified by observing the reversals in the normal compaction trend line. The pore pressure, fracture pressure, and gradients were calculated using the Eaton method. The method relies on the correlation between the normal transit time found on the normal compaction trend and the observed transit time from the log reading. The sonic log determines the bulk density and matches the density derived from the density log. Abnormal pressures were identified primarily within the area of interest, especially with unit B in Well 1. In Well 2, the abnormal pressures were recognized in zones above the area of interest. Abnormal pressures in Well 3 were identified primarily within all areas of interest. The importance of this work is to help predict overpressure zones in the research area before drilling or workover.

Abstract 561: Targeting Y box binding protein 1 (YBX1) in MYC-amplified medulloblastoma

Abstract Medulloblastoma is the most common malignant pediatric brain tumor. Patients diagnosed with MYC-amplified group 3 medulloblastoma (G3 MB) have a devastating prognosis with a 5-year survival rate of <50%. Standard of care (SOC) consists of maximal resection surgery followed by chemoradiotherapy, but these extensive treatments leave patients with neurocognitive and developmental deficits. Therefore, the identification of novel targets that can be used alone or in combination with SOC is of utmost importance. Using a batch-normalized bulk RNA-seq dataset (GSE124814) comprised of 1350 MB samples and 291 normal cerebella, we reveal upregulation of Y-box binding protein 1 (YBX1) in MB compared to normal cerebellum. Further analysis of this dataset and others demonstrates G3 tumors that display high MYC levels also have the highest YBX1 expression. Analysis of ChIP-seq data shows strong binding of MYC to the YBX1 promoter in G3 MB, concurrent with H3K27ac and H3K4me3 histone modifications. Using a well-established ex vivo model, we demonstrate increased YBX1 expression as normal cerebellar progenitor cells transition to tumorigenic G3 MB stem-like cells. Recent work in leukemia reveals a reciprocal regulation of MYC by YBX1, however, this mechanism is not well established in G3 MB. We utilized an orthogonal pharmacogenetic approach to inhibit YBX1 function and determine its effects on G3 MB tumor biology. Suppression of YBX1 significantly reduced the proliferation and decreased MYC protein expression of G3 MB cells in vitro. These findings support a reciprocal MYC-YBX1 axis, which could influence tumor growth in vivo. Orthotopic implantation of YBX1 KO G3 MB cells leads to increased animal survival. We next evaluated the therapeutic potential of two recently characterized YBX1 inhibitors which display single agent efficacy in vitro and in vivo. YBX1 inhibitors synergized with SOC in vitro lowering the IC50 for both chemo and radiotherapy, which could reduce adverse effects experienced by patients. In silico molecular docking using PyMOL predicts YBX1 inhibitors interact with amino acids within the cold shock domain of YBX1, likely impairing its ability to bind RNA. We performed formaldehyde RNA immunoprecipitation (fRIP)-sequencing to identify changes in RNA transcript levels following YBX1 pharmacological inhibition. Disruption of YBX1-RNA binding impacts the stability of known oncogenic transcripts which may be required for tumorigenesis. Our findings impart an alluring prospect of targeting YBX1 in combination with standard-of-care, and possibly other compounds to improve patients’ outcomes. Citation Format: Stephen Carney, John Hemenway, Ashmitha Rajendran, Matt Hathaway, Eric Nealy, Christian Bonatto, Dhanir Tailor, Sanjay Malhotra, Myron Evans. Targeting Y box binding protein 1 (YBX1) in MYC-amplified medulloblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 561.

INELASTIC LONGITUDINAL C6 ELECTRON SCATTERING FORM FACTORS IN Ti-50, (RESIDUAL INTERACTION CONSIDERATION)

The single orbit 1f7/2 has been adopted as a model space. The use of modern realistic M3Y effective nucleon- nucleon interaction with two sets of fitting parameters (Ried fitting (M3Y-P1), and Paris fitting (M3Y-P0)) beside the use of MSDI has been done as a residual interactions within the calculation of core polarization effects in Inelastic longitudinal electron scattering C6 form factor in Ti-50 within the framework of first order perturbation theory (microscopic theory) with 2ћω excitation energy coupling the core orbits to the higher configurations one across the model space at normal transition. Harmonic oscillator wave functions (H.O) has been adopted as a single particle wave functions in 1f7/2 and with the aid of F7MBZ model space 1f7/2 effective interaction to generate the model space wave functions. The present results have been compared with

Fat malabsorption in critical illness.

Malnutrition in critical illness is common and is associated with significant increases in adverse outcomes. A hypermetabolic state and underfeeding both contribute to the incidence of malnutrition. Malabsorption caused by critical illness is also an important contributor to the development of malnutrition. The early provision of enteral nutrition is associated with improved outcomes. Strategies for nutrition therapy must be informed by the alterations in absorption of macronutrients present in these patients. The following review examines alterations in fat metabolism during critical illness, and its consequences to overall nutrition status.Critical illness, as well as the sequalae of common medical interventions, may lead to alterations in the mechanical and chemical processes by which fat is digested and absorbed. Mechanical alterations include delayed gastric emptying and changes to the normal gut transit time. Pharmacologic interventions aimed at reducing these impacts may themselves, negatively affect efficient fat absorption. Exocrine pancreatic insufficiency can also occur in critical illness and may be underappreciated as a cause of fat malabsorption. Dysfunction of the gut lymphatics has been proposed as a contributing factor to fat malabsorption, and additional work is needed to better describe and quantify those effects. Achieving optimal outcomes for nutrition therapy requires recognition of these alterations in fat digestion.

South African adolescents' lived experiences of acquired hearing loss following multidrug-resistant tuberculosis treatment.

The impact of acquiring hearing loss might be exacerbated during adolescence, as this normal transition from childhood to adulthood is characterised by identity construction and social intensity. This study aimed to describe the lived experiences of South African adolescents with acquired hearing loss following aminoglycoside treatment for multidrug resistant tuberculosis. The study adopted a descriptive phenomenological design and in-depth, semi-structured interviews were conducted in English, isiZulu and Afrikaans. The data was managed and analysed according to a modified version of Hycner's framework. Six participants aged 16-24 years with bilateral, mild to profound hearing loss acquired from aminoglycoside treatment were recruited from two South African provinces. Three themes emerged which created a triple burden for participants. They endured socio-economic hardship encompassing limited economic and emotional support. Participants battled the consequences of life-threatening MDR-TB including illness, hospitalisation, stigma, and other challenges. Finally, participants were left with life-changing hearing loss. The findings indicate the necessity of holistic management of adolescents with aminoglycoside-related acquired hearing loss and serves as motivation to improve ototoxic monitoring practices and patient uptake of monitoring services and calls for the cessation, or at least cautious use, of aminoglycosides.

Simplified Methods for Modelling Dependent Parameters in Health Economic Evaluations: A Tutorial.

In health economic evaluations, model parameters are often dependent on other model parameters. Although methods exist to simulate multivariate normal (MVN) distribution data and estimate transition probabilities in Markov models while considering competing risks, they are technically challenging for health economic modellers to implement. This tutorial introduces easily implementable applications for handling dependent parameters in modelling. Analytical proofs and proposed simplified methods for handling dependent parameters in typical health economic modelling scenarios are provided, and implementation of these methods are illustrated in seven examples along with the SAS and R code. Methods to quantify the covariance and correlation coefficients of correlated variables based on published summary statistics and generation of MVN distribution data are demonstrated using examples of physician visits data and cost component data. The use of univariate normal distribution data instead of MVN distribution data to capture population heterogeneity is illustrated based on the results from multiple regression models with linear predictors, and two examples are provided (linear fixed-effects model and Cox proportional hazards model). A conditional probability method is introduced to handle two or more state transitions in a single Markov model cycle and applied in examples of one- and two-way state transitions. This tutorial proposes an extension of routinely used methods along with several examples. These simplified methods may be easily applied by health economic modellers with varied statistical backgrounds.

Evaluation of cerebral autoregulation of oxygen by NIRS method during postnatal transition period in term and late preterm newborns without resuscitation requirement.

Pulse oximetry is commonly used to monitor arterial oxygen saturation and heart rate during the transition period and reference intervals have been determined. However, the effect of the change in arterial oxygen saturation on tissue oxygenation does not seem to be the same. So, a non-invasive method for monitoring cerebral or regional tissue oxygenation will be potentially useful for vulnerable infants. This study aims to evaluate the effectiveness of cerebral autoregulation in the first 10 min after delivery in term and late preterm newborns without resuscitation requirement. Cerebral tissue oxygen saturation was measured in the first 10 min after birth with near-infrared spectroscopy (NIRS) from the left forehead. Peripheral oxygen saturation was measured with pulse oximetry from the right hand and cerebral fractional tissue oxygen extraction was calculated. Nineteen late preterms and 20 term infants were included in the study. There was no statistically significant difference between median cerebral tissue oxygen saturation and cerebral fractional tissue oxygen extraction values of late preterm and term infants (p < 0.001). There was a strong inverse relationship between cerebral tissue oxygen saturation and cerebral fractional tissue oxygen extraction (p < 0.001). In late preterm infants similar to term infants, arterial oxygen saturation and cerebral tissue oxygen saturation increased with time, but inverse reduction of cerebral fractional tissue oxygen extraction showed the presence of an active autoregulation in the brain. This can be interpreted as the ability of the brain to protect itself from hypoxia by regulating oxygen uptake during normal fetal-neonatal transition process. A larger scale multi-center randomized control trial is now needed to further inform practice.

Diagnosing Bilirubin Disease in Infants Using the Certainty Factor Method

Poor health and an unhealthy lifestyle are vulnerable to making a person more at risk of experiencing certain health problems or diseases. Bilirubin which is related to health is a metabolite in the form of a yellow pigment derived from the breakdown of heme in hemoglobin. Increased Bilirubin in newborns is a common problem that causes a normal or physiological transition during pregnancy. Al Fuadi General Hospital (RSU Al Fuadi) is a hospital located in Binjai that serves general public health. However, the large number of queues of patients waiting for examination results in a lengthy consultation process and treatment that will be received by Bilirubin sufferers. Based on the existing problems, an expert system is needed that can store information from an expert who can help the hospital. The Certainty Factor method is a method that can prove whether a fact is certain or uncertain in the form of metrics that are usually used in expert systems. Based on the results of trials conducted on this system it can be seen that the level belief from results diagnosis to disease i.e. 93% diagnosed with High Bilirubin disease.

Effect of Sildenafil in Neonates with Persistent Pulmonary Hypertension: An Interventional Study

Introduction: Persistent Pulmonary Hypertension of the Newborn (PPHN) reflects a disruption of the normal perinatal circulatory transition and is characterised by high pulmonary artery pressure. Inhaled Nitric Oxide (iNO) is considered the mainstay of treatment for PPHN. However, many developing and resource limited countries do not have access to such expensive therapy. Therefore, sildenafil, due to its easy availability and low cost, becomes the most commonly used drug in the management of PPHN in such settings. Aim: To study the treatment response and outcomes of neonates who received sildenafil for the management of PPHN. Materials and Methods: The present hospital-based prospective interventional study was conducted in the Neonatal Intensive Care Unit (NICU), BJ Medical College, Civil Hospital, Ahmedabad, Gujarat, between May 1, 2020, and April 30, 2021. Study was conducted on neonates with meconium aspiration syndrome and/or severe birth asphyxia admitted to the NICU. A total of 48 neonates with Two Dimensional (2D) echocardiography-proven PPHN were enrolled. Baseline clinical parameters including heart rate, respiratory rate, preductal and postductal Saturation of Peripheral Oxygen (SpO2), Oxygenation Index (OI), Saturation Oxygen Distending Pressure Index (SOPI), and Non Invasive Blood Pressure (NIBP) were monitored every six hours. Neonates who were on invasive/ non invasive ventilation had their Fraction of Inspired Oxygen (FiO2), Positive End Expiratory Pressure (PEEP), Peak Inspiratory Pressure (PIP), respiratory rate and flow rate monitored every six hours. Data were statistically analysed using Analysis of Variance (ANOVA) test. Results: During the study period, a total of 1080 neonates were admitted with meconium aspiration syndrome and/or severe birth asphyxia, out of which 48 neonates showed findings suggestive of PPHN on 2D echocardiography. A statistically significant improvement in oxygenation after sildenafil treatment was indicated by a significant reduction in OI from 35.3±8.6 to 13.2±2.1 (p-value&lt;0.001), a reduction in SOPI from 3.6±0.3 to 1.5±0.2 (p-value&lt;0.001), a reduction in FiO2 (%) from 94.6±8.19 to 24.2±4.5 (p-value&lt;0.001), an increase in Partial pressure of oxygen (PaO2) (mmHg) from 52±5.6 to 72±3.4 (p-value&lt;0.001), and an increase in SpO2 (%) from 83.5±8.6 to 93.5±5.1 (p-value&lt;0.001). Conclusion: The findings of the present study suggest that oral sildenafil can be successfully used to improve oxygenation in patients with PPHN, especially in a resource limited setting where facilities like Extracorporeal Membrane Oxygenation (ECMO) and iNO are not available, as demonstrated in the present study.

Controlling the Charge Density Wave Transition in Single-Layer TiTe2xSe2(1-x) Alloys by Band Gap Engineering.

Closing the band gap of a semiconductor into a semimetallic state gives a powerful potential route to tune the electronic energy gains that drive collective phases like charge density waves (CDWs) and excitonic insulator states. We explore this approach for the controversial CDW material monolayer (ML) TiSe2 by engineering its narrow band gap to the semimetallic limit of ML-TiTe2. Using molecular beam epitaxy, we demonstrate the growth of ML-TiTe2xSe2(1-x) alloys across the entire compositional range and unveil how the (2 × 2) CDW instability evolves through the normal state semiconductor-semimetal transition via in situ angle-resolved photoemission spectroscopy. Through model electronic structure calculations, we identify how this tunes the relative strength of excitonic and Peierls-like coupling, demonstrating band gap engineering as a powerful method for controlling the microscopic mechanisms underpinning the formation of collective states in two-dimensional materials.

Searching for Unconventional Superfluid in Excitons of Monolayer Semiconductors.

It is well known that two-dimensional (2D) bosons in homogeneous space cannot undergo real Bose-Einstein condensation, and the superfluid to normal phase transition is Berezinskii-Kosterlitz-Thouless (BKT) type, associated with vortex-antivortex pair unbinding. Here we point out a 2D bosonic system whose low energy physics goes beyond conventional paradigm of 2D homogeneous bosons, i.e., intralayer excitons in monolayer transition metal dichalcogenides. With intrinsic valley-orbit coupling and valley Zeeman energy, exciton dispersion becomes linear at small momentum, giving rise to a series of novel features. The critical temperature of Bose-Einstein condensation of these excitons is nonzero, suggesting true long-range order in 2D homogeneous system. The dispersion of Goldstone mode at long wavelength has the form ϵ(q)∼sqrt[q], in contrast to conventional linear phonon spectrum. The vortex energy deviates from the usual logarithmic form with respect to system size, but instead has an additional linear term. Superfluid to normal phase transition is no longer BKT type for system size beyond a characteristic scale, without discontinuous jump in superfluid density. With the recent experimental progress on exciton fluid at thermal equilibrium in monolayer semiconductors, our work points out an experimentally accessible system to search for unconventional 2D superfluids beyond BKT paradigm.

Incommensurate to normal phase transition in malayaite

Incommensurate to normal phase transition in malayaite

Velocity structure (1D) and earthquakes relocation in the flat-slab to normal plate transition zone in the Argentinean transarc

The Argentinean Andean foreland region between latitudes 31°S to 33.5°S presents an intense crustal and upper mantle seismic activity that was recorded by a local seismological network called CHARSME (Chile Argentina SeisMic Experiment), and was used to obtain new velocity determinations. In a first moment, from 4 P-wave velocity (VP) models proposed by other authors, the detail in the layers was increased, resulting in better models used as initial model in the investment. Finally, by carefully selecting a set of earthquakes, a simultaneous velocity inversion, hypocentre determination and station correction were performed using the VELEST code. In order to obtain better velocity models (VP and VS) and VP/VS ratio, different tests were carried out in all processes.The final VP model presented in this paper incorporates considerations made in other seismological studies. This model accurately determined velocities between 10 and 65 km depth. The upper mantle velocity (VP) was defined in 8.05 km/s. From the Wadatti diagram, which represents a line whose slope is related to the wave velocities and the Poisson's coefficient, a VP/VS value of 1.732 was obtained. Alternative VP/VS values were also considered to invert VP, VS and VP/VS simultaneously. The minimum detailed model of VP, VS and VP/VS decreased the RMS by 25% relative to the initial models, implying an improvement in the uncertainty of locations. The new and precise locations of crustal earthquakes allowed defining clusters within Cuyania, a tectonic terrain that collided to Gondwana in the Early Paleozoic. Although it is known that foreland seismicity is mainly concentrated in this terrain, this work shows that there are well-defined zones within Cuyania that are more seismically active. Earthquakes of intermediate depth (upper mantle) are strongly agglomerated in the flat-slab zone of the subducting Nazca Plate.The discontinuities present in our model suggest upper, middle and lower crustal structuring, as well as a marked contrast between the sediments and the underlying basement. It was possible to interpret an upper crust consisting of sediments and basement to a depth of 25 km, a middle crust between 25 and 45 km and a lower crust between 45 and 55 km. We also defined the Mohorovičić (Moho) discontinuity at 55 km depth. The crustal velocities are in agreement with previous seismological studies.

Evidence of caged to normal diffusion transition in benzene along supercritical isobars: Insights from molecular dynamics simulations

Understanding the behavior of supercritical fluids holds both fundamental and practical significance. From a practical standpoint, these fluids find numerous technological applications across environmental, mechanical, chemical, biological, and geothermal industries. However, from a fundamental scientific perspective, unraveling the intricate structure, thermodynamics, and dynamics of supercritical fluids remains an ongoing challenge. In this work, we address this task by employing NPT molecular dynamics simulations on a rigid benzene model under high pressures. Our observations reveal a striking dynamical transition, with a caged regime at low temperatures and a normal diffusion regime at high temperatures. Notably, the subdiffusive region aligns with the compressible region from the experimental phase diagram, while the normal diffusion occurs in the supercritical region. Furthermore, we present compelling evidence linking the subdiffusion to a caged trajectory and illustrate how uncaging and clustering play a key role in the dynamical transition. The identification of the subdiffusive and normal diffusion regimes provides valuable information for optimizing processes involving supercritical fluids in various industries. Moreover, the link between caged trajectories and dynamical transitions adds a new dimension to our understanding of molecular behavior in supercritical systems.

A Neuroendocrine Approach to Treat Menopausal Vasomotor Symptoms: A Brief Clinical Overview

Vasomotor symptoms of menopause are a major health issue faced by millions of postmenopausal women. Although menopause is considered a normal physiological transition, its deleterious effects on the overall well-being of women have long been understood by health care providers. Although hormones work best for the treatment of vasomotor symptoms, limited nonhormonal pharmacologic agents are available. A newly approved first in its class nonhormonal neuroendocrine agent called fezolinetant is available now. It is important for providers to have an in-depth understanding about the indications, benefits, and risks of this new therapeutic agent and offer it as an alternative to hormone therapy.