Normal Test Results Research Articles

Toxicity test of mangosteen peel extract (Garcinia mangostana L.) as denture cleanser of heat-cured acrylic resin: in vitro experimental laboratory

ABSTRACTIntroduction: Mangosteen peel extract can be used as a denture cleaning agent to effectively inhibit the growth of C. albicans because mangosteen peel contains various compounds such as mangostin, tannins, flavonoids, saponins. Denture cleaning materials that will be used in the dental field must meet biocompatibility requirements, one of which is a toxicity test. The aim of this study was to analyze the toxicity of mangosteen peel extract as a cleaner of heat cured acrylic resin denture on BHK-21 as cell culture of fibroblast cells. Methods: Toxicity test used the MTT assay method. Acrylic resin samples had a diameter of 3 mm and a thickness of 2 mm. The acrylic resin was soaked for 4 days, equivalent to soaking 15 minutes per day for 1 year in mangosteen peel extract with concentrations of 50, 60, 70%, and sodium hypochlorite. Analyzed data using normality and homogeneity test results showed (p<0.05). Kruskal Wallis test results (0.000<0.05) and Mann Whitney (0.000<0.05). Results: The greatest cell viability value was shown in mangosteen peel extract with a concentration of 50%, namely 97.16939%. Based on research data, it can be said that the lower the concentration of mangosteen peel extract, the lower the level of toxicity of a denture cleanser agent. Mangosteen peel extract in concentrations of 60, 70%, and sodium hypochlorite are toxic when used as a denture cleanser. Conclusion: Mangosteen peel extract with a concentration of 50% is not toxic to BHK-21 fibroblast cells as cell culture of and as a cleaner of heat cured acrylic resin denture on.Keywordheat-cured acrylic resin, mangosteen peel extract, MTT assay.

Retrospective genetic testing (Traceback) in women with early-onset breast cancer after revised national guidelines: a clinical implementation study

PurposeThis study focused on identifying a hereditary predisposition in women previously diagnosed with early-onset breast cancer through a retrospective outreach activity (Traceback). The objectives were to evaluate the possible clinical implementation of a simplified Traceback strategy and to identify carriers of pathogenic variants among previously untested women.MethodsThree hundred and fifteen Traceback-eligible women diagnosed with breast cancer at 36–40 years in Southern Sweden between 2000 and 2019 were identified and offered an analysis of the genes ATM, BARD1, BRCA1, BRCA2, CHEK2, PALB2, RAD51C, and RAD51D through a standardized letter. Women who chose to participate were asked about their experiences through a questionnaire. The workload for the study personnel was measured and recorded.ResultsOne hundred and seventy-six women underwent genetic testing and pathogenic variants were identified in 9.7%: ATM (n = 6), BARD1 (n = 1), BRCA1 (n = 3), CHEK2 (n = 5), and PALB2 (n = 2). Women with normal test results were informed through a standardized letter. Carriers of pathogenic variants were contacted by telephone and offered in-person genetic counseling. One hundred and thirty-four women returned the subsequent questionnaire. Most study participants were satisfied with both written pre- and post-test information and many expressed their gratitude. The extra workload as compared to routine clinical genetic counseling was modest (8 min per patient).ConclusionThe insights from the participants’ perspectives and sentiments throughout the process support the notion that the Traceback procedure is a safe and an appreciated complement to routine genetic counseling. The genetic yield of almost 10% also suggests that the associated extra workload for genetic counselors could be viewed as acceptable in clinical implementation scenarios.

Increasing the Endurance of Futsal Athletes by Providing Green Bean Porridge

This research aims to find out whether there is an increase in the endurance of futsal athletes through feeding green bean porridge. Experimental type of research. Experimental research is research that seeks to find the influence of certain variables on other variables under strictly controlled conditions. So the population of this study was all futsal athletes at SMA Negeri 9 Makassar. A sample of 10 people was obtained based on the criteria, namely males aged 15-17 years using a purposive sampling technique. The data analysis techniques used are descriptive tests, normality tests, and T-tests (hypothesis tests) using a computer via SPSS 16.0 with a sig level of 0.05. Based on data analysis, the results of descriptive tests with the group given green bean porridge obtained an average value (mean) of 37.61 with a standard deviation of 2.99 a minimum value of 32.90, a maximum of 41.10. The group without giving green bean porridge obtained an average value (mean) of 34.64 with a standard deviation of 3.49 a minimum value of 29.50 and a maximum of 39.90. The results of the data normality test were with a total of Asymp= 0.99 (pretest) and with a total of Asymp= 0.65 (posttest) where the value of sig0.00 <0.05. Hypothesis test results (T-test) data between the pretest and post-test have a mean difference of 92.97) so it can be concluded that there is an increase in giving 100 grams of green bean porridge to vo2Max in futsal athletes at SMA Negeri 9 Makassar.

The Effect of Double Triangle and Double Square Trainings on Passing Results in Disporasu Football Players Aged 10-11

This research aims to determine the effect of double triangle and double square training on passing results in football players aged 10-11 years at Disporasu Football School (FS) in 2022. The research method used is an experimental method, namely to see a change from before treatment and after treatment and then in compare. This research uses a research design, namely one group pretest-posttest design. This research has a population of 18 people from the entire 10-11 year age category in Disporasu FS in 2022, to make it easier in the research the researcher has certain criteria, then the sample is taken using a purposive sample technique, namely a conditional sampling technique, so it can be obtained The sample was 14 people. The time of this research was carried out 18 meetings. The data collection techniques used in this research are tests and measurements. The test instrument used in this research was the football short pass test. The data analysis technique used is the normality test, the results of the pretest data normality test are Lcount 0.1493 and posttest data 0.1472 with Ltable 0.227 with the conclusion that the data is normally distributed, homogeneity test, the data homogeneity test results state that Fcount is 1.21 with Ftable 2 .58, then the conclusion that can be drawn is that the data comes from homogeneous variance and the t test with the help of SPSS 21. The results of the t-test state that there is a value of Tcount=16.60442, then the value of Tcount is compared with the value of Ttable with dk=n-1 (dk=14-1=13) at a significance level of ά=0.05, so we get Ttable=2 .16037, so that based on the hypothesis testing criteria it is stated that at Tcount=16.60442 > Ttable=2.16037, so Ho was accepted.

Orthognathic surgery in a patient with von Willebrand disease

Aim: This study aims to report the perioperative management of a patient with von Willebrand disease (vWd) who underwent orthognathic surgery. The report follows the guidelines of the Case Report Guidelines (CARE) and focuses on the steps taken to prevent bleeding during the surgical procedure. Methods: A 39-year-old female patient with skeletal Class III was treated with maxillary advancement and mandibular setback. Despite normal test results for ristocetin cofactor activity, measures were taken to prevent bleeding, including atraumatic surgical techniques, use of antifibrinolytic medication, induced hypotension during anesthesia, and preparation of blood products for transfusion during trans and postoperative periods if needed. In the end, these measures were not required. Results: The patient did not experience any bleeding during the surgical procedure or postoperative period, demonstrating the effectiveness of the measures taken to manage their blood dyscrasia. Two years after the surgery, the patient had satisfactory aesthetic and functional results and no evidence of relapse. Conclusion: Thus, this case report demonstrates that vWd does not prevent largescale oral and maxillofacial surgeries such as orthognathic surgery as long as proper precautions are taken pre-, intraand postoperatively.

Roselle (HibiscussabdariffaL.) calyces tea improves physical fitness of healthy adults.

Roselle calyces (Hibiscus sabdariffa L.) is a plant that contains anthocyanin and flavonoids, which function as exogenous antioxidants for the human body to counteract excess oxidative stress. Roselle has anti-hypertensive, anti-cancer and anti-diabetic effects. The present study evaluated roselle to see whether it affects physical fitness. The components of physical fitness include strength, balance, right and left hand grip, vertical jump and VO2max (maximum oxygen consumption). A total of 30 subjects received 200 ml rosella tea for 30 days every morning and evening. Every week, subjects were assessed for physical fitness. Data analysis used paired t and Wilcoxon test according to the normality test results. The results showed significant improvements in strength (from 24.9 to 27.3 kg; P=0.025), balance (from 23.3 to 42.2 sec; P=0.004), right (from 31.8 to 35.1 kg; P<0.0001) and left hand grip (from 29.8 to 31.6 kg; P=0.020), vertical jump (from 38.6 to 41.1 m/sec; P=0.008) and VO2max (from 31.1 to 34.3 ml/kg/min; P=0.014). This demonstrated that roselle significantly improved six parameters of physical fitness and may be used as a supplement to improve physical fitness without severe side effects.

P364 Faecal calprotectin testing in patients presenting with lower gastrointestinal symptoms; a retrospective primary care study in the United Kingdom

Abstract Background Faecal calprotectin (FC) is of value in differentiating Inflammatory Bowel Disease (IBD) from other causes of lower gastrointestinal (GI) symptoms and is recommended in national guidance. This study aims to examine the role of and factors associated with faecal calprotectin requesting in primary care. Methods Retrospective open cohort study using Clinical Practice Research Datalink (CPRD Aurum) of adults aged 18 years and above with lower GI symptoms between 2015 and 2019. FC requested 30 days before to 3 months after a lower GI symptom record in primary care were included. Logistic regression model was used to explore patient level factors associated with FC testing. Referral pathways and outcomes in terms of IBD diagnoses of patients with and without FC testing were also examined. Results Of 741,190 symptomatic patients, only 18,320 (2.5%) patients had a FC requested in primary care: median age 38.3 (IQR 28.9-50.7); 51.4% females. The percentage of FC requests in symptomatic patients increased from 0.02% in 2010 to 4.4% in 2019 (p=0.001). FC value of &amp;lt;50 ug/g and 50-200 ug/g were predominantly seen in patients with abdominal pain (42.1% and 37.9% respectively) while FC &amp;gt; 200 ug/g was predominantly seen in patients with diarrhoea (45.3%). The only patients with a significant risk of IBD with a FC 50-200ug/g were patients with rectal bleeding (8%). Factors associated with less FC requesting included: increasing age (&amp;gt;70 years aOR 0.16 ( 95% CI 0.15-0.18); female (0.89,0.86-0.92); Black (0.61, 0.56-0.66) or Asian (0.75, 0.70-0.80) ethnicity; obesity (0.89,0.85-0.93); lower socioeconomic status (0.91,0.86-0.98); comorbidity score &amp;gt;2 (0.73,0.68-0.79); and current smoking (0.89,0.85-0.92). Patients with change in bowel habit (7.31,6.90-7.75); rectal bleeding (2.04,1.95-2.13); diarrhoea (2.88,2.78-2.99) as a presenting symptom compared to abdominal pain and ex-smokers (1.06,1.03-1.11) had more FC requests. Of patients referred with a FC &amp;gt;200 ug/g, 21.5% were diagnosed with IBD but only 2.9% of patients with a FC 50-200ug/g. 27.8% patients with a normal FC test result were still referred to secondary care, of which only 0.4% had IBD. Conclusion Despite an increase in FC requests in recent years, only 4.4% of patients with relevant lower GI symptoms had an FC requested in primary care as recommended. Despite a negative FC test, 27.8% of patients were still referred to secondary care with very few patients diagnosed with IBD (0.4%).

Analysis of The Relationship of Land Transportation With GRDP in Wholesale and Retail Trade Sector, Car and Motorcycle Reparation

Transportation Land transportation influences national economic growth. Due to the existence of land transportation modes, the national economy can continue to grow from year to year. This study analyzed the variable relationship between land transportation through road length data, road condition data, and GRDP in the wholesale and retail trade sectors. The results of this study show that good national road conditions have a very low positive correlation (0.079). And has an insignificant relationship to GRDP (0.665 0.05). National road conditions have a shallow level of positive correlation (0.074). And has a negligible relationship to GRDP (0.679 0.05). Damaged national road conditions have a superficial negative correlation (-0.040). And has an insignificant relationship to GRDP (0.823 0.05). National road conditions severely damaged did not pass the requirements test, normality test results (0.024 0.05). Provincial road conditions are good, with a positive correlation (0.681). And has a significant relationship to GRDP (0.00 0.05). Medium local roads have a good level of positive correlation (0.586). And has a substantial relationship to GRDP (0.00 0.05). The condition of damaged provincial roads has a low negative correlation (-0.103). It has an insignificant relationship to GRDP (0.563 0.05). The condition of the badly damaged national road does not pass the requirements test, the normality test (0.024 0.05). Moderate district/city road conditions have an average positive correlation (0.356). And has a significant relationship to GRDP (0.039 0.05). The condition of district/city roads is damaged and has a shallow correlation level of (0.105). It has an insignificant relationship with GRDP (0.555 0.05). The condition of district/city roads is badly damaged and has a shallow correlation level of (0.105). It has an insignificant relationship with GRDP (0.555 0.05). The condition of district/city roads is damaged and has a shallow correlation level of (0.105). It has an insignificant relationship with GRDP (0.555 0.05). The condition of district/city roads is badly damaged and has a shallow correlation level of (0.105). It has an insignificant relationship with GRDP (0.555 0.05). The condition of district/city roads is damaged and has a shallow correlation level of (0.105). It has an insignificant relationship with GRDP (0.555 0.05). The condition of district/city roads is badly damaged and has a shallow correlation level of (0.105). It has an insignificant relationship with GRDP (0.555 0.05).

Pengaruh Variasi Drill Dropshot terhadapPeningkatan Ketepatan Dropshot pada Siswa SMAN 4 Sungai Penuh

Based on the background of the problem, the accuracy of dropshot shots of SMAN 4 Sungai Penuh students is still low. Based on the results of observations when doing training or conducting matches, SMAN 4 Sungai Penuh students are very lacking in performing badminton dropshot skills, and there are often mistakes in making a movement that should be able to reach the ball easily and returned to the opponent, but the results cannot be returned at all. Therefore, to find out the above problems, the authors conducted drilling exercises to increase dropshot on students of SMAN 4 Sungai Penuh to improve the ability of dropshot shots to be better. This study aims to determine the effect of dropshot drill variation on improving dropshot accuracy in students of SMAN 4 Sungai Penuh. The research conducted is an experimental study conducted with the aim of knowing whether or not there is an effect of something that is imposed on the sample to be studied. This research was conducted at the Juanda Sport badminton court and PBSI Hall Sungai Penuh City with 12 athletes with details of the initial test, namely the test before doing the drill training method and the final test, namely the test after doing the drill training method. Based on data analysis, the research has been proven by the results of a normal normality test, a homogeneous homogeneity test and a T test with Thitung 10.10 whose results are significant with a comparison of Ttabel 2.22 this means that the research hypothesis is accepted at the 95% confidence level. So it can be concluded that drilling practice can improve the accuracy of dropshot on students of SMAN 4 Sungai Penuh. So the researcher suggests that sports trainers and teachers provide variations of racket dropshot drill exercises to improve dropshot accuracy in badminton activities.

DEVELOPMENT OF PINKI (INDONESIAN CULTURE INTERACTIVE BOARD) WITH STRENGTHENING THE CURIOSITY OF CLASS IV STUDENTS

The development of PINKI learning media aims to produce learning media that are valid, practical and effective in strengthening one of students' curiosity. Combined with the presence of technology in it can make this learning media interactive. This development uses the RD method and the ADDIE development model. Data collection techniques were carried out by interviewing, observing and giving questionnaires to material experts, media experts and teachers. While the technique of collecting data students are given questionnaires and questions. The validation results from validator 1 reached an average percentage of 92.87%, validator 2 achieved an average percentage of 96.52% with a very valid category of all validators. The practicality of students is 98.38% and that of teachers is 100.00% so that it is in the very practical category. The processing results of the data normality test were normally distributed, and the results of the paired sample t test sig (2-tailed) were 0.000 0.05 with a decision finding found significant differences in the learning process before and after using PINKI learning media. Thus, the PINKI learning media was stated to be very valid, very practical and effective in strengthening students' curiosity so that it could be used in the process of learning cultural diversity material in class IV East Java Province.

Pengaruh Insentif dan Komitmen Organisasional terhadap Motivasi Kerja Dosen pada Institut Agama Islam Negeri Kerinci

This This abstract discusses the work motivation of lecturers at the Kerinci State Islamic Institute (IAIN) with a focus on the influence of incentives and commitment on work motivation. This research methodology involves the use of a questionnaire distributed to 70 IAIN Kerinci lecturers to collect primary data. Data collection also involved interviews, library research, and field research. Data analysis includes testing validity and reliability using statistical programs, such as SPSS. The test results show that most of the statements in the questionnaire are valid and reliable for use in this research. Descriptions of respondents based on age, gender, education and marital status are also presented in this abstract. Apart from that, there is an explanation of the results of the data normality test which shows that the incentive, commitment and work motivation variables have a distribution that tends to be normal. In this research, it is explained that there is a significant influence between incentives, commitment and work motivation on.

Effect of Aloe Vera Extract in Inhibit of Candida albicans on Cured Acrylic Resin Plates

Introduction: Removable dentures are either whole or partial. Fixed dentures are firmly affixed to the patient's teeth. Dentures reduce functional problems caused by tooth loss, but many individuals don't realize how crucial cleaning them is. Long-term denture use can hinder the tongue and saliva's cleaning of the dental mucosa. Thus, Candida albicans cling better to denture bases and primary agen in candidiasis oral. Aloe vera leaves contain six antimicrobial compounds that prevent the growth of various fungi, bacteria, and viruses, including Candida albicans and Staphylococcus pyogen. Objective: Knowing the effect of aloe vera extract (Aloe vera) with a concentration. Methods: The research method is True Experimental Laboratory, which uses a research design in post-test-only control groups. The Kruskal-Wallis test was used to analyze and interpret the research data results, and the Mann-Whitney U test was used as a follow-up analysis. Results: The normality test results showed a p-value of 0.033 in the control group of aquades smaller than 0.05. This proves that the control equates are generally not distributed because the p-value is smaller than 0.05 (p-value 0. The p-value 0.05 was obtained in the control group, proving that the control group is normally distributed. In the homogeneity test, a p-value of 0.000, smaller than 0.05, is obtained. This proves that the test data results in the control and treatment groups are not homogeneous. Conclus inhibits the development of Candida albicans in heat-cured acrylic resin.

Breast Cancer Prediction Based on Multiple Machine Learning Algorithms.

The incidence of breast cancer has steadily risen over the years owing to changes in lifestyle and environment. Presently, breast cancer is one of the primary causes of cancer-related deaths among women, making it a crucial global public health concern. Thus, the creation of an automated diagnostic system for breast cancer bears great importance in the medical community. This study analyses the Wisconsin breast cancer dataset and develops a machine learning algorithm for accurately classifying breast cancer as benign or malignant. Our research is a retrospective study, and the main purpose is to develop a high-precision classification algorithm for benign and malignant breast cancer. To achieve this, we first preprocessed the dataset using standard techniques such as feature scaling and handling missing values. We assessed the normality of the data distribution initially, after which we opted for Spearman correlation analysis to examine the relationship between the feature subset data and the labeled data, considering the normality test results. We subsequently employed the Wilcoxon rank sum test to investigate the dissimilarities in distribution among various breast cancer feature data. We constructed the feature subset based on statistical results and trained 7 machine learning algorithms, specifically the decision tree, stochastic gradient descent algorithm, random forest algorithm, support vector machine algorithm, logistics algorithm, and AdaBoost algorithm. The results of the evaluation indicated that the AdaBoost-Logistic algorithm achieved an accuracy of 99.12%, outperforming the other 6 algorithms and previous techniques. The constructed AdaBoost-Logistic algorithm exhibits significant precision with the Wisconsin breast cancer dataset, achieving commendable classification performance for both benign and malignant breast cancer cases.

HPV Positive Women and Risk Factors in Development Cervical Intraepithelial Lesions

Background: Human papillomavirus is a risk factor in the development of cervical cancer. Other risk factors are frequent vaginal infections, cigarette smoking, use of oral contraceptives, but also lack of lacrobacillus in women with HPV infection. Objective: The objective of our study was to determine the risk factors for the development of cervical intraepithelial lesions in women with normal and pathological Pap test results. Methods: The research is a prospective study conducted in the Gynecology Center "Dr. Mahira Jahić" Tuzla and Dom Zdravlja Tešanj since February. 2023 to March 2024. The research included 200 respondents aged 25 to 50. Tested group: 100 subjects with pathological Pap smear findings (ASCUS, LSIL and HSIL) and a control group of 100 subjects with normal Pap smear findings. Sociodemographic data were obtained from the subjects during interviews and examinations: age, cigarette consumption and frequency of previous vaginal infections and the presence of lactobacilli. The obtained results were processed using the methods of descriptive statistics, student's t test and X2 test. A difference for a value of p&lt;0.5 was considered statistically significant. Results: The mean age of the dpbo examined group was 38.1±1.7, while in the control group it was 39.6±1.9 years. Cigarettes were consumed by 62 (31%), 38 (19%) of the examined group, and 24 (12%) of the control group with a statistically significant difference of p&lt;0.05. Out of a total of 100 in the examined group, 60 subjects had LSIL, 9 subjects had HSIL (CIN 2 two subjects and CIN 3 had 7), and ASCUS 29 and ASC-H 2 subjects. Subjects with pathological findings had significantly more vaginal infections during one year (p&lt;0.05). HPV was positive in 65 (65%) subjects with a pathological Pap smear test, and negative HPV in 35 (35%). HPV 16,18 was present in 19 (19%) test subjects in combined form, and mono-isolate HPV 16 in 14 (14%) and HPV 18 in one case. In the combined form of several HPVs, HPV 16 and HPV 31, 33, 35, 45, 56 were found in 5 (5%), and HPV 18 in 4 (4%) with HPV 36, 59, 68. The most frequently isolated HPV 16 in 38 (38%) as monoisolate and in combined form. Lactobacilli were present in 26 (13%) subjects in the test group and in 60 (30%) subjects in the control group, with a statistically significant difference (p&lt;0.05). The presence of Lactobacillus in subjects with a regular Pap test is significantly more frequent compared to women with cervical intraepithelial lesions (ASCUS, LSIL, ASC-H and HSIL) ) in the finding of the Pap test. Conclusion: Altered microflora of the vagina, lack of lactobacilli, frequent vaginal infections and smoking are risk factors for the development of CIN lesions in women positive for high-risk HPV.

MACULOPAPULAR CUTANEOUS MASTOCYTOSIS HARBORING A KIT MUTATION (ASP419DEL): A CASE REPORT

A 2-year-old, male patient presented with an 18-month history of scattered, brown macules and nodules up to 2 cm in size on his trunk and extremities. These macules were accompanied by pruritus and were positive for Darier's sign. A skin biopsy of a brown macule on the left thigh revealed a dense accumulation of CD117-positive, round or oval cells with amphophilic cytoplasm within the upper to middle dermis. The patient was otherwise healthy and had normal laboratory and imaging test results. Sequence analysis of genomic DNA from a skin biopsy demonstrated the presence of an Asp419del mutation in exon 8 of the KIT gene. Based on these findings, maculopapular cutaneous mastocytosis (MPCM) was diagnosed. The patient received H 1-antihistamine. Although the pruritus resolved, the brown macules remained for one year after the initial treatment. To the best of our knowledge, only three cases of cutaneous mastocytosis (CM) with an Asp419del mutation, including the present case, have been reported in the Japanese literature to date; moreover, while the previous two cases were of DCM, the present case was the first instance of MPCM. Normally, the symptoms of childhood-onset MPCM are dormant until puberty. However, a recent study reported that many MPCM patients may experience persistent or exacerbated symptoms. The present study therefore evaluated 53 Japanese cases of childhood onset MPCM with a KIT gene mutation and discussed the patients' clinical outcomes.

Unusual Presentation of Double-seronegative Myasthenia Gravis with Positive Anti-LRP4 Antibody: Diagnostic Utility of a Videofluoroscopic Swallowing Study.

An 86-year-old woman was admitted to our hospital with cryptogenic progressive dyspnea and dysphagia following a tracheostomy procedure 4 months prior to presentation. She exhibited fluctuating diplopia, bilateral vocal fold paralysis, normal nerve test results, negative findings for serum anti-acetylcholine receptor and anti-muscle-specific kinase antibodies, and positive findings for anti-LDL-receptor related protein 4 (LRP4). A videofluoroscopic swallowing study (VFSS) with edrophonium revealed an improvement in bulbar paralysis. Consequently, the patient was diagnosed with double-seronegative myasthenia gravis (DSN-MG) and began immunomodulatory therapy. This case emphasizes the diagnostic challenges of bulbar-type DSN-MG and underscores the value of a VFSS with edrophonium for diagnosing this condition.

Mesalamine induced hepatotoxicity. Is mesalamine safe?

Dear Editor: Mesalamine is a medication used widely in the treatment of patients with inflammatory bowel disease. Although mesalamine is considered safe, hepatotoxicity has been reported with an incidence of 0-4%. We present the clinical picture of a patient with hepatotoxicity due to mesalamine. A 79-year-old woman in the context of chronic diarrhea, a left-sided ulcerative colitis diagnosis was made, and treatment was initiated with oral mesalamine 4 g per day, and mesalamine suppositories. Before starting treatment, she had normal liver test results. After three months, she presented with headache, fatigue, and intermittent low fever. Her laboratory tests showed a liver profile with a cholestatic pattern, and elevation of inflammatory parameters. Mesalamine was suspended, and an extensive study was performed. Cholangioresonance reported intra and extrahepatic bile duct dilation without obstruction, and thickening of the intrahepatic bile duct. She progressed with worsening of the liver profile without signs of liver failure. A liver biopsy was performed, which showed chronic non-suppurative cholangitis with granulomas and focal concentric fibrosis related to medium-caliber bile ducts, and IgG4 stain was negative.

Use of Paci and Alum to Reduce Tss Levels in People's Rubber Soaking Liquid Waste

The coagulants used are PACl and alum because, in addition to their low price, PACl and alum are also proven to reduce turbidity and TSS levels in wastewater. This study aimed to determine the effect of PACl and alum on reducing TSS levels in people's rubber bath waste. This type of research is classified as an actual experiment, utilizing a pretest and posttest design with a control group. Integrated sampling was the sampling technique used in this study. Statistical analysis is performed using the normality test, and if the data is normally distributed, it is continued with the one-way ANOVA test. The normality test results showed average distributed TSS level data. They continued the Anova test (p = 0.005 &lt; ɑ = 0.05), which found a difference between PACl and alum coagulant in reducing TSS levels in people's rubber immersion liquid waste. A PACl dose of 1200 mg/L lowered TSS levels by 46%. While the alum dose of 3000 mg/LL has not been able to reduce TSS levels, The variation in the dose of PACl and alum coagulants should be reduced again to be optimal for reducing TSS levels in liquid waste. To meet the quality standards of rubber immersion waste by reducing TSS levels, liquid waste with acidic or alkaline properties needs a neutralization process by adding lime.

Pengaruh Waktu Penyangraian Terhadap Karakteristik Fisikokimia Kopi Bubuk Robusta Menggunakan Mesin Roasting Elektrik

The quality of coffee powder can be improved if the main stages of the roasting process can be carried out optimally. Hot air-type roasting machines with a combination of 10 minutes and a temperature of 200 C can produce high-quality coffee powder. Therefore, other research is needed using different types of roasting machines and coffee powder quality criteria based on standards set by the government. The electric roasting machine consists of a Teflon heating mat that is directly integrated with temperature-adjustable heating components and has an automatic stirrer. The study used a one-factor Complete Randomized Design (CRD) with four treatment levels and two repeats. The Roast time of robusta coffee beans at a temperature of 200 C with levels (10, 15, 20, and 25) minutes is factor A. The criteria for testing the quality of coffee powder produced by the electric roasting machine state (smell, color, taste) with normal test results, water content ranges from 1.47-5.29%, ash content ranges from 3.53-3.83%, coffee juice ranges from 24.1-25.6%, and caffeine ranges from 1.66-1.78%. Electric roasting machines at a temperature of 200 C and 10 minutes are the best combination of treatment because the ground coffee produced is quality. I am referring to SNI 01-3542-2004 criteria for criteria tested with the most optimal electrical energy efficiency

APPLICATION STRATEGY LEARNING HEURISTICS IN INCREASE RESULTS STUDY MATHEMATICS STUDENT CLASS V ELEMENTARY SCHOOL

&lt;em&gt;The problem of learning mathematics at SD 06 satai c class v shows that learning outcomes are still low, this research aims to 1) To determine the increase in learning outcomes using heuristic learning strategies in class V of SD Negeri 06 Satai C. 2) To see the results of mathematics learning reaching the KKM individually by implementing heuristic learning strategies in class V of SD Negeri 06 Satai C. 3) To find out whether student learning activities are classified as good in debit material when heuristic learning strategies are applied. The research used was a quasi experimental design research with a one group pretest-posttest design. The population of this study was class V students at SD Negeri 06 Satai C. The sample was class V with a total of 24 students. N-Gain test to see improvements in student mathematics learning outcomes. The result is N-Gain = 0,318 with medium criteria in the range 0,3 ≤ N – gain &amp;lt; 0,7. The results show that there is an increase. Next, use the one sample t-test formula. The normality test results showed that &lt;/em&gt;&lt;em&gt;&lt;/em&gt;&lt;em&gt; was 6,355 and &lt;/em&gt;&lt;em&gt;&lt;/em&gt;&lt;em&gt; was 7,814. Because &lt;/em&gt;&lt;em&gt;&lt;/em&gt;&lt;em&gt; ≤ &lt;/em&gt;&lt;em&gt;&lt;/em&gt;&lt;em&gt; is 6,355 ≤ 7,814, it is normally distributed, so it is known that &lt;/em&gt;&lt;em&gt;&lt;/em&gt;&lt;em&gt;= 5,915 and &lt;/em&gt;&lt;em&gt;&lt;/em&gt;&lt;em&gt; = 2,010, we get &lt;/em&gt;&lt;em&gt;&lt;/em&gt;&lt;em&gt; &lt;/em&gt;&lt;em&gt;&lt;/em&gt;&lt;em&gt; = 5,915 &lt;/em&gt;&lt;em&gt;&lt;/em&gt;&lt;em&gt; 2,010 then H&lt;sub&gt;a&lt;/sub&gt; is accepted and H&lt;sub&gt;o&lt;/sub&gt; is rejected. So it can be concluded that individual students' mathematics learning outcomes reach the KKM. Next, to find out students' learning activities, use an observation sheet. From the data, the percentage of student learning activities is 85%. This shows that students' learning activities during learning are in the very active category and are classified as good.&lt;/em&gt;