Background: Thrombocytopenia which is dened as circulating platelet count below 150×109/L, is one of the uncommon extra-hepatic manifestation of Chronic hepatitis B infection.1 Thrombocytopenia in Chronic hepatitis B infection mainly attributes to hepatic cirrhosis of liver, autoimmune destruction of direct platelets and megakaryocytes, impaired production of platelets due to impaired thrombopoietin production.2–4 Objective: To assess the platelet count in chronic hepatitis B patients and its association with the severity of hepatic brosis. Materials and methodology: Ahospital based observational study was conducted among 70 chronic hepatitis B patients where chronic hepatitis B infection was conrmed by HbcIg-Total and HbcIgM ELISA kit test. Platelets were being counted with the help of microscope and neubauer slide. Severity of brosis is graded by liver point shear wave elastography machine. Results:Among the 70 Chronic hepatitis B patients 24 patients were found have thrombocytopenia. Value of mean platelet count (in ×109/L) were 327.14±62.07, 224.14±72.56, 191.88±18.89, 157.55±13.24 and 121.43±60.71 in normal hepatic status; mild, signicant, severe brosis and cirrhosis respectively. Conclusion: From the study thrombocytopenia can be considered as one of the extra-hepatic manifestations in CHB patients where the platelet count is found to be inversely proportional to the severity of hepatic brosis with signicant association (p value < 0.0001).