Background: Chronic obstructive pulmonary disease is a respiratory disease. COPD patients present not only with the features of respiratory tract infections (cough, dyspnea, etc.) but also with other comorbidities. Cardiovascular disease is one of them. COPD and CVD cause various metabolic disturbances like dyselectrolytemia. Aim: Study of serum electrolytes in patients suffering from COPD with or without CVD. Method: in a hospital-based study that included 109 confirmed COPD patients. In our study, first we diagnosed the COPD using spirometry, then we assessed the serum electrolyte level with an echocardiograph in all the confirmed COPD patients. Results: Normal serum sodium levels were found in 69 patients (69/109; 63.30%) with or without CVD, the majority of patients (40/69; 70.18%) in the without CVD group. 32 patients (32/109; 29.36%) were found to have hyponatremia, of which 13 patients (13/32; 40.63%) were included in the without CVD group and 19 patients (19/32; 59.38%) were included in the with CVD group.