Although the effects of highly chlorinated naphthalene compounds on the pilosebaceous apparatus of man have been observed repeatedly since Herxheimer described chloracne, few reports of experimental production of the syndrome in man have been available until recently (1, 6, 10). Suskind (10) in a series of studies in 1954 produced definite changes in the forearm skin after 10 days of topical application of 20 per cent Halowax 1014 f in Plastibase}. Histologically, beginning about the fourth or fifth day, there was evidence of follicular reaction without appreciable effect on sebaceous glands. In studying the responses of the pilosebaceous structure of the rabbit's ear canal skin (5), it was observed that definite stimulation of the follicular wall and sebaceous gland duct epithelium with striking diminution of sebaceous glands occurred within five to seven days following daily topical application of 3 per cent Halowax 1014 in acetone. Regrowth of normal sebaceous glands occurred following discontinuance of the applications.