Normal Fiber Research Articles

Randomized Clinical Study of Nano-Cerium Oxide and its Efficacy in Sciatic Nerve Regeneration: A Histopathological Evaluation

Background: Peripheral nerve damage is a frequent clinical condition. peripheral nerve injuries are variable, and these injuries are mostly caused by trauma. Blunt trauma has many types, including contusion, laceration, stretching, traction, penetrating and perforating injuries, abnormal sleeping positions, external pressure, internal compression, ischemia. Cerium oxide nanoparticles are used widely in the materials field. Besides their material applications. Objective: this study was examining how cerium oxide nanoparticles impact axonal regeneration of the sciatic nerve in rats. Materials and Methods: 24 adult animals used, weighing average (M±SD: 230 ± 20 g). The animals were separated into two group. The first group (control) was left without treatment, The second group (Nano cerium Oxide) was treated orally with 50 mg of Nano cerium oxide daily for 7 days. Right Sciatic nerve was completely transected in all animals. The result evaluated at 4th, 8th and 12th weeks post-operative. Results: The histopathological results, indicated that the high effective result in the second group, then the control group. The control group has a significant nerve damage and some regenerative signs over time. While there are indications of severe damage particularly at 4 and 8 weeks, then presence of almost normal nerve fibers at 12 weeks suggests partial recovery. Conclusion: Nano Cerium Oxide accelerated the regeneration of the peripheral nerves These findings suggest that this nanoparticle could can be seen as a novel therapy for promoting the regeneration of the nervous system.

Dissipative soliton resonance in a normal dispersion all-polarization-maintaining thulium-doped fiber laser

We report a first demonstration of dissipative soliton resonance (DSR) in a normal dispersion thulium-doped fiber laser (TDFL) constructed entirely of polarization-maintaining fibers. A nonlinear fiber loop mirror with a combination of normal and anomalous dispersion fibers inside the loop ensures a self-starting mode-locking operation in the DSR regime. The oscillator generated linearly polarized optical pulses with a fundamental repetition frequency of 5.735 MHz and a nearly constant peak power clamped at ∼ 4.35 W. The pulse duration extends from 217 ps to 6 ns, when the pump power increases from 417 mW to 1.86 W. The maximum average output power of the DSR pulses was 151 mW, corresponding to the single pulse energy of 26 nJ.

Investigation on 2D SiCf/SiC composite scribing mechanism by single- and double-grit

To validate the proposed removal mechanism of 2D SiCf/SiC composite, single- and double-grit scribing experiments were conducted on the fiber woven surface (WS) and stacking surface (SS) along the 0°, 45°, and 90°. The results indicate that transverse fibers mainly undergo shear, tensile, and bending fractures. The removal modes of normal fibers are shear and bending fractures. The longitudinal fibers are damaged by tensile (cut-in side) and bending (cut-off side) fractures, accompanied by fiber peel-off. The removal forms of the matrix include crack propagation, ductile scratch, powdery removal, and brittle peel-off. The order of scribing force is FSS0 > FWS45 > FSS90 > FWS0. The maximum and minimum scribing force occur on SS0 and WS0, respectively, due to the powdery removal of matrix and fibers + matrix peel-off. The 2nd grit scribes the matrix layer and fiber tip in a very low depth to cause powdery and ductile removal, which exhibit the different material removal mechanism with the 1st grit. The scribing damage formed by 1st grit greatly reduces the force required by the 2nd grit for the same material removal volume. The coupling effect among grits in multi-grit scribing and grinding cannot be ignored.

DTI Tractography

The DTI technology used to observe the Nerve fascicle - Nerve fascicle imaging was also discussed in detail. Two types of deterministic and probabilistic traction imaging were compared from effectiveness and computational efficiency perspectives. Then an experimental study was conducted using different software to compare the fiber bundles of the subjects brain and the normal brain and to evaluate the impact of different angle thresholds on the number of observable fiber bundles. Research has confirmed that the subjects whole brain fiber bundle imaging reconstruction was successful, and there was no significant difference compared to the normal brain fiber bundle. The study also found a specific quantitative relationship between the angle threshold and the number of fiber bundles. This experiment also explored the differences in connectivity strength between the brain regions of the left and right brains and their significance.

Research of Pulmonary Fibrosis Lesions Based on FLIM and SHG Imaging Microscopy.

Two-photon fluorescence lifetime microscopy (TP-FLIM) is a powerful quantitative imaging technique that characterizes and analyzes the structure and function of biological samples through a combination of intensity and lifetime imaging. Because TP-FLIM is independent of the fluorescence signal intensity and the fluorophore concentration, it is widely used in high-throughput, high-content drug screening and clinical diagnostics. Second harmonic generation (SHG) imaging technology has the advantages of high spatial resolution and imaging depth inherent to nonlinear optical imaging. Second harmonics often appear in noncentrosymmetric structures. Collagen tissue in biological organisms is a good example of these structures, showing strong harmonic effects. Therefore, SHG has been widely used for imaging of specific tissue structure imaging. TP-FLIM technology is highly sensitive for quantitatively detecting changes in microenvironments. The objective of this study is to examine pathological pulmonary fibrosis slices using a combined approach of TP-FLIM and SHG technology. The fluorescence lifetime data of pulmonary collagen fibers are analyzed by using phasor plot analysis methods, and normal collagen fibers and fibrotic collagen fibers are distinguished by calculating the aspect ratio from the SHG images formed by the collagen fibers. Our study provides a new method for a deeper understanding of the pathological mechanisms and clinical diagnosis of pulmonary fibrosis and other collagen fiber-related disorders.

Passively harmonic dissipative soliton generation in normal dispersion erbium-doped fiber laser using SMS fiber as artificial saturable absorber

Passively harmonic mode-locking has been experimentally demonstrated in an erbium-doped fiber laser with large normal dispersion using single-multi-single mode structure as artificial saturable absorber. By increasing the pump power under the same polarization setting, the mode-locking operation can switch from fundamental mode-locked to 5th order harmonic mode-locked. Highest repetition rate of 4.26 MHz (5th order harmonic) is observed, with pulse width and pulse energy ascertained at 290 fs and 3.0 nJ, respectively. Excellent signal-to-noise ratio (SNR) of above 50 dB is observed for all harmonic orders. The findings validated that SMS structure can be used to generate stable and switchable high order of harmonic mode-locked. The low-cost SMS fiber for harmonic mode-locked generation technique could lay the groundwork for future sustainable industrial growth.

Mechanical behavior of twinning-induced plasticity (TWIP) steel fibre reinforced cementitious composite under impact loading

Twinning-induced plasticity (TWIP) steel fibre is a supermaterial known for its outstanding impact resistance. This paper, for the first time, applied TWIP steel fibre to increase the impact resistance of cementitious composites. The mechanical properties behaviours of TWIP steel fibre-reinforced cementitious composites (T-SFRCC) were investigated and compared with conventional SFRCC with normal steel fiber. The fractal theory was utilized to analyze the deterioration of damage in various SFRCCs subjected to impact loads, displaying TWIP steel fiber could prevent the cracks propagation and fewer fractal dimension compared with others. Results demonstrate that T-SFRCC has comparable compressive strength to SFRCC while exhibiting higher flexural strength. When subjected to impact loading, T-SFRCC demonstrates markedly improved energy absorption and impact toughness, such as better impact force and displacement. Specifically, the energy absorption capacity of T-SFRCC can exceed five times that of SFRCC with corrugated steel fiber, particularly evident when the drop height reaches 1200 mm. The influences of different fiber types and hammer drop methods on the impact resistance of SFRCCs were also discussed, which can provide reference for TWIP steel fiber in the field of cementitious composite materials.

Experimental study of light transmitting concrete with ultra-high content of polymethyl methacrylate

Light Transmitting Concrete (LTC) is an innovative material for crafting unique and sustainable architectural and civil structures. Previous studies primarily utilized optical fibers with diameters below 1.5 mm, which did not exceed 10 % of the volumetric content in concrete. This study aims to develop LTC with ultra-high light transmission capabilities while preserving its mechanical strength. An important innovation is the use of polymethyl methacrylate (PMMA) with larger diameters than normal optical fibers. Specifically, PMMA fibers of 2.0 mm diameter and PMMA tubes of 10–20 mm diameter were employed to increase the spacing between these materials when arranged in an ultra-high volumetric content within the concrete, facilitating easier compaction of the fresh concrete. Experiments of the material's mechanical properties, microstructure, and optical performance were conducted. The findings suggest that although the increased PMMA content might reduce the concrete’s mechanical strength due to a smaller effective cross-sectional area, the LTC still achieves compressive strength exceeding 40 MPa. This underscores the viability of LTC with a substantially higher content of light transmitting functional materials compared to previous studies, while still maintaining a mechanical strength greater than normal concrete. The light transmission efficiency of LTC is nearly directly proportional to its PMMA content, and able to reach up to 30 % of the light source's intensity. Additionally, LTC with PMMA fibers provides uniform light distribution across its surface because of scattering, while LTC with larger-diameter PMMA tubes focuses light around the core areas due to direct lighting.

Performance of steel fibre reinforced lightweight aggregate concrete in fresh and hardened state

Abstract There is a growing interest in the manufacture of lightweight aggregate concrete (LWC) due to its low density, which is below 2000 kg/m3. However, the trade-off for the lower density is a reduction in strength, leading to a drop in crack resistance. Therefore, steel fibre inclusion was implemented to augment the crack resistance of lightweight concrete (LWC). Thus, the present study aims to examine the impact of steel fibre on both the workability and mechanical properties of lightweight aggregate concrete (LWC) that incorporates lightweight expanded clay aggregate (LECA). Three varieties of concrete were fabricated, namely normal weight aggregate concrete (NC), lightweight concrete (LWC), and steel fibre lightweight concrete (SFWLC). The SFLWC incorporated hooked-end steel fibres as reinforcement, with fibre volume percentages of 1 % and 2 %. A strength assessment was undertaken to ascertain the concrete properties, with particular emphasis on compressive and tensile strength. The findings indicate that the incorporation of both LECA and steel fibre led to a notable reduction in the workability of concrete. Incorporating a 2 % steel fibre content into LWC yields a marginal enhancement in compressive strength. Steel fibre demonstrates enhanced efficacy when subjected to tension, with the most significant increase measured at around 152 %.

Norepinephrine Reuptake Inhibition, an Emergent Treatment for Neurogenic Orthostatic Hypotension.

The NET (norepinephrine transporter) is situated in the prejunctional plasma membrane of noradrenergic neurons. It is responsible for >90% of the norepinephrine uptake that is released in the autonomic neuroeffector junction. Inhibitors of this cell membrane transporter, known as norepinephrine reuptake inhibitors (NRIs), are commercially available for the treatment of depression and attention deficit hyperactivity disorder. These agents increase norepinephrine levels, potentiating its action in preganglionic and postganglionic adrenergic neurons, the latter through activation of α-1 adrenoreceptors. Previous studies found that patients with neurogenic orthostatic hypotension can improve standing blood pressure and reduce symptoms of neurogenic orthostatic hypotension after a single administration of the selective NRI atomoxetine. This effect was primarily observed in patients with impaired central autonomic pathways with otherwise normal postganglionic sympathetic fibers, known as multiple system atrophy. Likewise, patients with normal or high norepinephrine levels may benefit from NRIs. The long-term efficacy of NRIs for the treatment of neurogenic orthostatic hypotension-related symptoms is currently under investigation. In summary, an in-depth understanding of the pathophysiology of neurogenic orthostatic hypotension resulted in the discovery of a new therapeutic pathway targeted by NRI.

Investigation of basic properties, microscopic characteristics, and optimized ratio prediction model of ultra-high steel fiber reinforced concrete

Ultra-high steel fiber reinforced concrete (UHSFRC) has poor workability and a low cost-performance ratio, and the application of active admixtures can overcome these shortcomings of UHSFRC. This work investigated the feasibility of fly ash (FA) and silica fume (SF) to improve the performance of SFRC and evaluate the effects of FA and SF on the workability, mechanical properties, microstructure, and economic/environmental performance of UHSFRC. The results showed that FA and SF can increase the slump, compressive, and splitting tensile strength of UHSFRC. Compared with control tests, the slump, 28-d compressive, and 28-d splitting tensile strength increased by 43.25 %, 29.35 %, and 55.72 %, respectively. More importantly, microscopic analysis showed that FA and SF have balling, filling, and adsorption effects, and increase peak intensity of C-S-H gel and ettringite, promoting secondary hydration of cement. According to the experimental data and mechanistic analysis, an innovatively optimized ratio prediction model is adopted to establish the relationship between the slump, compressive, and splitting tensile strength of UHSFRC and the content of FA and SF, and the testing error was less than 5 %, indicating that the model is feasible. Moreover, the effect of FA and SF content on cost-performance ratio, carbon emission, and energy consumption of UHSFRC was predicted. The economic/environmental analysis showed the mixing of FA and SF can improve the cost-performance ratio of UHSFRC and reduce carbon emission and energy consumption. This study can provide theoretical guidance for the improvement of the workability and mechanical properties of UHSFRC, and have important research implications for the improvement of the life cycle assessment of UHSFRCs. The results of the study also have some limitations, and further validation is needed for normal steel fiber concrete (compressive strength of 30–60 MPa, with fibers with a length of 30–60 mm and diameter of approx. 1 mm).

Study on the Characteristics of Coarse Feeding Tolerance of Ding'an Pigs: Phenotypic and Candidate Genes Identification.

Ding'an (DA) pig, a prominent local breed in Hainan Province, exhibits notable advantages in coarse feeding tolerance and high-quality meat. To explore the potential genetic mechanism of coarse feeding tolerance in DA pigs, 60-day-old full sibling pairs of DA and DLY (Duroc-Landrace-Yorkshire) pigs were subjected to fed normal (5%) and high (10%) crude fiber diets for 56 days, respectively. The findings showed that increasing the crude fiber level had no impact on the apparent digestibility of crude fiber, intramuscular fat, and marbling scores in DA pigs, whereas these factors were significantly reduced in DLY pigs (p < 0.05). Through differential expression analysis and Weighted Gene Co-expression Network Analysis (WGCNA) of the colonic mucosal transcriptome data, 65 and 482 candidate genes with coarse feeding tolerance in DA pigs were identified, respectively. Joint analysis screened four key candidate genes, including LDHB, MLC1, LSG1, and ESM1, potentially serving as key regulated genes for coarse feeding tolerance. Functional analysis revealed that the most significant pathway enriched in differential genes associated with coarse feeding tolerance in Ding'an pigs was the signaling receptor binding. The results hold substantial significance for advancing our understanding of the genetic mechanisms governing coarse feeding tolerance in Ding'an pigs.

Dynamic Lane Reversal in Traffic Management

Investigate the properties of concrete in order to understand the change in properties of concrete using recycled concrete aggregate (RCA) with addition of glass fiber in this research study. In this research study normal concrete cubes and glass fibers concrete cubes were prepared to differentiate it easily.In this research glass fiber is used at different ratios with respect to cement ratios to prepared the cubes having size of 6” x 6” x 6” were prepared and cured it properly at curing tank. After this the cubes were tested at compression testing machine at different days like 14, 21 and 28 days accordingly. The ratio of glass fiber were used at 3, 6 and 10%. Compressive strength of both normal and fiber cubes were used to differentiate between it on different days

Experimental investigation on bond behaviour of the GFRP bars with normal and high strength geopolymer concrete

The study presents the experimental investigation of bond performance of normal and high-strength geopolymer concrete and Glass Fibre Reinforced Polymer (GFRP) bars. The effects of bar diameters, embedment lengths, and concrete grades on maximum pullout load and failure characteristics are investigated. When the adhesive and residual strengths of GFRP bond specimens were compared to steel specimens, the former demonstrated remarkable performance despite having differing surface properties. An energy-based equivalent bond strength approach is proposed to examine pre-peak bond performance, which demonstrating that the decreasing rate of strength is faster for higher diameter and embedment, showing a drop in bond performance. Pullout failure was noted in smaller diameter bond specimens, where the shear strength between the ribs and the GFRP bar controlled the bond strength. Concrete split failure occurs for 12 mm specimens with embedment lengths greater than 5d in both GPC40 and GPC60. Specimens with 16 mm, excluding G-16-5d-60, demonstrated concrete split failure for all embedment lengths and concrete grades; bond strength is determined by the concrete shear strength. Enhancing the concrete’s compressive strength has a beneficial impact on the bond strength as it increases ranging, from 14.57 to 32.12%. Analytical models such as mBPE and CMR were employed to derive the mathematical expression for the bond stress versus slip curve. It was found that the curves of CMR model were typically closer to experimental curves than the mBPE model.

Reducing Cf/SiC composite damages through collaborative control of laser ablating depth and grinding modes

Cf/SiC composites are regarded as difficult-to-machine aerospace materials. A low-damage surface machining of Cf/SiC composite by laser-ablating assisted grinding (LAAG) was conducted, and investigated the effects of laser-ablating depth and grinding modes on surface/subsurface damages. The results showed that ablated material depth reached 420 μm after 1200 times scanning, while the effective ablating rate was inhibited by the depth. Compared with down grinding, the grinding forces and temperatures were substantially higher in up grinding, with a maximum increase of 123.5 % and 140 % in normal and tangential grinding forces, respectively; however, micro brittle fracture and ductile removal were remarkably enhanced in normal and transverse fibers, and surface macroscopic damage has been suppressed; subsurface damage remained insignificant, mainly exhibited in internal micro cracks and minor interfacial debonding. It was attributed to cutting characteristics of up grinding. Furthermore, as grinding depth increased, the material removal behavior underwent a brittle-ductile transition and the surface roughness grew accordingly. Moreover, a laser scanning angle of 0° and up grinding facilitated the occurrence of longitudinal fiber debonding, producing larger sized fiber bundle chips. Combining up grinding with 90° scanning angle at low grinding depth was an effective method to improve the surface quality of Cf/SiC composite.

Innovative Method for Reinforcing Beams with Different Types of Concrete Using Cross-Rod Steel Bracing Under Pure Torsion

This study aimed to investigate the effectiveness of an innovative way to reinforce the concrete beams using cross-rod steel bracing under pure torsion. The experimental program consists of casting and testing eighteen concrete beams made of three types of concrete in the form of three groups, with the same dimensions for all beams (200×200×2000) mm. The parameters of the study included concrete types (normal strength, high strength, and steel fiber), as well as the number of internally cross rods (4, 8, 12, 16, 20). The experimental results showed that the number of internally cross-rod reinforcements and concrete type had an effect on ultimate torque, crack width, toughness, and stiffness. The torsional capacity of all concrete beams increased with the increase in internally cross-rod reinforcement. The ultimate torque of normal-strength concrete beams, high-strength concrete beams, and steel fiber concrete beams reinforced with twenty internally cross rods increased (88.34%, 53.20%, and 40.60%), respectively, compared to beams without cross rods in each type of concrete beam. Increasing the internally cross rod in all concrete beams effectively inhibited the development of crack width and improved torsional stiffness, especially in fibrous concrete beams that contained steel fiber. The torsional toughness of all concrete beams increased with the increase of internally cross-rod reinforcement, and it was higher in steel fiber concrete beams. The steel fiber concrete beams reinforced with internally cross-rod steel bracing have better torsional properties compared to ordinary concrete beams and high-strength concrete beams. Doi: 10.28991/CEJ-2024-010-04-06 Full Text: PDF

Comparative analysis of the integration of autologous and allogeneic cryopreserved tendons in the femoral canal on a model of laboratory animals

Allogeneic tendon grafts are seriously demand in knee joint plastic surgery. The novel method of tendon cryopreservation, including sterilization with supercritical carbon dioxide, was developed in N.V. Sklifosovsky Research Institute for Emergency Cryopreserved tendons retain their normal fiber structure without significant loss of mechanical properties. At the next stage it was necessary to evaluate cryopreserved tendons′ integration inside bone canal in experimental animals.The aim of study. To evaluate morphologic changes of autologous and allogeneic tendons inside the femur in rats and to determine the effect of tendon transplantation on the physical activity.Material and methods. The study was conducted on white inbreed male rats. Three groups of animals were formed: the control group (animals without tendon transplantation), the 1st experimental group – animals with autologous tendon transplantation, the 2nd experimental group – animals with allogeneic tendon transplantation. In animals of the experimental groups the through channel was formed in the distal metaepiphysis of the femur and a tail tendon graft 0.5 x 0.1 cm was placed there. To assess the physical activity of the animals, we studied maximum distance that the animals could run 3 and 6 weeks after transplantation was determined, using treadmill test. The graft structure was evaluated on histological preparations in transmitted light, stained with hematoxylin-eosin and Van Gieson′s stain. To assess the preservation of collagen fibers we checked the autofluorescence intensity of collagen.Results. According to the treadmill test, the distance run by the animals of both experimental groups did not significantly differ from the values in the control group. Histological analysis after 3 weeks in both experimental groups revealed signs of fibers′ decomposition in the absence of inflammatory infiltration and maintaining close contact with bone trabeculae. The autofluorescence intensity of the collagen fibers in grafts corresponded to normal or was close to normal. After 6 weeks, the animals of both experimental groups revealed areas of graft fusion with their own bone, Sharpe fibers were actively formed. In both groups, numerous small vessels with diameters up to 10 microns were detected in the area of tendon-bone contact. Infiltration of grafts by inflammatory cells was absent or very insignificant, active migration of fibroblasts to the tendon area was also not observed. In both groups, tendon grafts had areas where fiber decompactization was observed. In the area of contact with the bone, the autofluorescence of tendon fibers was sharply increased, which indicates the chemical cleavage of collagen. At 3 and 6 weeks after transplantation the effect of fixation (integration) of the tendon with bone tissue was observed in both experimental groups.Conclusions. Allogeneic tendon grafts did not cause a pronounced inflammatory or immune reaction in experimental animals. 6 weeks after transplantation of autologous and allogeneic tendons, the integration of grafts inside the femoral canal was observed. Cryopreserved allogeneic tendons were able to integrate into the body's own tissues without pronounced structural and functional disorders. According to the treadmill test, the distance covered by the animals of both experimental groups did not differ statistically significantly from the values in the control group (without tendon transplantation) after 3 and 6 weeks

Transmission challenges in metropolitan area optical networks

Abstract For implementing wide/metropolitan area network in optical fiber communication system the key technology that can be utilized is wavelength division multiplexing (WDM). We discuss the use of WDM in metropolitan networks along with its special feature of using optical add drop multiplexers and also design issues in implementing these systems. The issue of nonlinear crosstalk induced in metropolitan networks is considered in terms of power penalty. Also, the effect of dispersion induced in optical fibers is considered by using two types of transmission systems. One is considering the non-zero dispersion shifted fiber (NZDSF) in dispersion effected environment and second is, implementing dispersion compensation after normal single mode fiber (SMF + DCF). The effect of nonlinear cross talk which can limit transmission performance is discussed in both cases in context with different parameters like power penalty, frequency difference between signal &amp; crosstalk and transmission distance etc.

Unnatural Amino Acid-Based Ionic Liquid Enables Oral Treatment of Nonsense Mutation Disease in Mice.

This investigation addresses the challenge of suboptimal unnatural amino acid (UAA) utilization in the site-specific suppression of nonsense mutations through genetic code expansion, which is crucial for protein restoration and precise property tailoring. A facile and economical oral liquid formulation is developed by converting UAAs into ionic liquids, significantly enhancing their bioavailability and tissue accumulation. Empirical data reveal a 10-fold increase in bioavailability and up to a 13-fold rise in focal tissue accumulation, alongside marked improvements in UAA incorporation efficiency. A 4-week oral administration in mdx mice, a model for Duchenne muscular dystrophy (DMD), demonstrates the formulation's unprecedented therapeutic potential, with up to 40% dystrophin expression restoration and 75% recovery of normal fiber functions, surpassing existing treatments and exhibiting substantial long-term safety. This study presents a potent oral dosage form that dramatically improves UAA incorporation into target proteins in vivo, offering a significant advance in the treatment of nonsense mutation-mediated disorders and holding considerable promise for clinical translation.

Switching and transformation of multi-state solitons in a slightly normal dispersion mode-locked fiber laser

Passively mode locked fiber lasers are excellent platforms for soliton generation. Here, multi-state switchable behaviors in a slightly normal dispersion mode-locked fiber laser are experimentally demonstrated with an identical configuration. A saturable absorber based on single-wall carbon nanotube is served as mode-locking device and an intrinsic birefringence spectral filtering is employed as a tunable inline filter. Consequently, with properly modifying pumping powers and orientations of polarization controller paddles, the operation regimes of the proposed laser could be reversibly switched between dissipative solitons and amplifier similaritons, and the characteristics of intermediate states are recorded. Tunable dissipative solitons with a tuning range of 38 nm and noise-like pulses could also alternatively be generated. This multi-state behavior switching could be attributed to the strong filtering caused by the limited gain bandwidth under strong pump strength. The experimental observations of these multi-state switchable transitions may offer insight into the pulse regime dynamics in the near-zero dispersion region and offer flexibility in multi-functional designs of the laser configuration, which would enable innovations in nonlinear optics and its applications.