Average Face Research Articles

Investigating the Relationship between the Dimensions and Morphology of Sella Turcica with the Long-Face Growth Pattern and the Vertical Growth Pattern.

The sella turcica is one of the important landmarks of lateral cephalometry, which is used in orthodontics for the diagnosis, treatment plan, and evaluation of skeletal development and maturity. The purpose of the present study is to investigate the relationship between the dimensions and morphology of sella turcica with the long-face growth pattern and people with an open bite. This study also examines the relationship between sella turcica bridging (STB) and the vertical growth pattern. As many as 153 radiographs were analyzed using the Romexis software, considering the basal, gonial, and FMA angles to determine the vertical growth pattern of the face. The basal angle was also used to check for an open bite. Of these patients, 80 had a long vertical face growth pattern, and 73 had a normal face growth pattern. The four landmarks of tuberculum sellae, dorsum sellae, sellae floor, and posterior clinoid were determined on the cephalograms to measure the length, depth, and anteroposterior diameter of the sella turcica. In this study, it was found that the chance of developing a long face in people with partial and complete bridging is 8.37 and 1.92, respectively. An increase in the length of the sella turcica for one unit decreases the chance of a long face, and as the depth of the sella turcica increases, the chance of a long face increases. STB is frequently seen in people with long faces. However, this finding should be considered in relation to other diagnostic parameters. The shorter the length and higher the depth of sella turcica, the higher the chance of developing a long face.

Catastrophe Bond Diversification Strategy Using Probabilistic–Possibilistic Bijective Transformation and Credibility Measures in Fuzzy Environment

The variety of catastrophe bond issuances can be used for portfolio diversification. However, the structure of catastrophe bonds differs from traditional bonds in that the face value and coupons depend on triggering events. This study aims to build a diversification strategy model framework using probabilistic–possibilistic bijective transformation (PPBT) and credibility measures in fuzzy environments based on the payoff function. The stages of modeling include identifying the trigger distribution; determining the membership degrees for the face value and coupons using PPBT; calculating the average face value and coupons using the fuzzy quantification theory; formulating the fuzzy variables for the yield; defining the function of triangular fuzzy membership for the yield; defining the credibility distribution for the triangular fuzzy variables for the yield; determining the expectation and total variance for the yield; developing a model of the catastrophe bond diversification strategy; the numerical simulation of the catastrophe bond strategy model; and formulating a solution to the simulation model of the diversification strategy using the sequential method, quadratic programming, transformation, and linearization techniques. The simulation results show that the proposed model can overcome the self-duality characteristic not possessed by the possibilistic measures in the fuzzy variables. The results obtained are expected to contribute to describing the yield uncertainty of investing in catastrophe bond assets so that investors can make wise decisions.

Translation and validation of the Role Checklist into the Malay version among retirees

Introduction: Retirees undergo role transition after leaving their job. Hence, occupational therapists may assess retirees’ roles to identify their current roles’ satisfaction and anticipation. As Malaysian culture and language differed from the origin of the Role Checklist, this study aimed to translate and validate the Role Checklist into the Malay version cross-culturally. Methodology: A forward–backwards translation was conducted, followed by pilot testing among 9 experts and 20 retirees. A cross-sectional study was done among 122 Malaysian retirees to identify the translated instrument’s test–retest reliability, discriminant and convergent validity. Findings: The Role Checklist – Malay achieved almost perfect Average Content Validity Index (0.95–0.98) and Average Face Validity Index (0.92–0.96), good to excellent test–retest reliability with intraclass correlation coefficients = 0.654–0.976, and moderate to perfect agreement of Cohen’s kappa (0.620–1.00). Additionally, there were significant differences in the total number of roles ( p < 0.001) and total desired future roles ( p < 0.001) between retirees living in the community and institution. The total number of roles was positively correlated with the SWLS – Malay ( rs = 0.593, p < 0.001), EQ-5D-3L – Malay ( rs = 0.366, p < .001) and MSPSS – Malay ( rs = 0.314, p < 0.001). Conclusion: The Role Checklist – Malay was a valid and reliable instrument among Malaysian retirees.

Preference for Averaging in East Asian Faces: A Source of Potential Guidance in Aesthetic Plastic Surgery.

Relatively little research has been done on the application of objective tools in guiding Ethnic Plastic Surgery in Asian patients. The evolutionary psychology theory of koinophilia, or love of average features, presents the basis for a solution to build a foundation for crowd-sourced East Asian aesthetic standards. The authors hypothesize that the averaged composite face in a cohort will be viewed as significantly more attractive than their respective cohort. Cohorts were created based on the gender of the individual in the photograph (40 females and 40 males of East Asian descent). Two surveys were created, 1 for the female cohort and the other for the male. The surveys assessed the aesthetic preference of each photograph using a Likert scale ranging from 1 to 7. Surveys were distributed using the popular crowdsourcing program Amazon Mechanical Turk (Amazon, Seattle, WA). The authors received 875 respondents for the male cohort survey and 876 respondents for the female cohort survey. For both the female and male cohorts, the composite images had a statistically significantly higher rating (P < .001) than the mean of the other images. Among other significant demographic findings, when considering both ethnicity and location of residence, Asian raters living in Asia preferred the composite significantly more than Asian raters living in North America (P < .001). Raters' preference for the composite average face is in concordance with the evolutionary psychology literature. Thus, this study affirms the utility of using facial composites to guide surgeons in identifying aesthetic standards for patients of East Asian descent.

Objectively measured facial traits predict in-person evaluations of facial attractiveness and prosociality in speed-dating partners

Many studies have investigated whether facial averageness, masculinity, and similarity are associated with facial attractiveness. These studies have relied on ratings of images of real or digitally morphed faces. It is important to establish whether past findings translate to real-life, face-to-face evaluations of potential partners; lack of effects in this context would cast doubt on the evolutionary relevance of previous findings. Further, previous studies have not considered that, by definition, faces that are more similar to the average face (i.e. higher in averageness) tend to be more similar to raters' faces. Therefore, these image-rating studies, which separately found that averageness and (in some cases) similarity are attractive, are confounded. To address these issues, we conducted a laboratory-based speed-dating study of 682 participants with objectively measured facial traits, where opposite-sex pairs rated each other on facial attractiveness and prosociality. We found that facial attractiveness was predicted separately by averageness and by similarity (to the rater), but with both variables in the same model, neither uniquely predicted attractiveness. Similarity, but not averageness, predicted prosociality ratings. Facial masculinity was positively and negatively associated with facial attractiveness ratings of men and women, respectively. These results confirm, in real-life interactions, some key findings from image-rating studies but raise questions about others, notably the attractiveness of facial averageness.

Contextual processing and its alterations in patients with addictive disorders

Contextual processing is implicated in the pathophysiology of addictive disorders, but the nature of putative deficiencies remains unclear. We assessed some aspects of contextual processing across multimodal experimental procedures with detoxified subjects who were dependent on opioids (n = 18), alcohol- (n = 20), both opioids and alcohol (n = 22) and healthy controls (n = 24) using a) facial- and b) emotionally laden images; c) gambling task and d) sucrose solutions. Healthy subjects displayed consistent response pattern throughout all categories of the presented stimuli. As a group, dependent subjects rated (i.e., valuated) attractive and average faces respectively more and less attractive in comparison to controls. Dependent subjects' motivational effort, measured in the units of computer keypress to determine the attractive faces' viewing time, accorded the valuational context but was diminished relatively to the average faces’ valuation. Dependent subjects’ motivational effort for pleasant and aversive images respectively mirrored the attractive and average faces; their neutral images’ motivational effort was incongruent with the valuational context framed by the intermixed images. Also, dependent subjects’ emotional responses to counterfactual comparisons of gambling outcomes were unmatched by the riskiness context. Moreover, dependent subjects failed to show greater liking of sweet solutions that normally accompanies low sweetness perceptual context indicative of higher sucrose concentration needed for maximal hedonic experience. Consistent differences among the dependent groups (opioid vs. alcohol vs. comorbid) on the above procedures were not observed. The present findings suggest that opioid and/or alcohol dependence may be associated with amplified hedonic and motivational valuation of pleasant stimuli and with a disrupted link between behavioral/emotional responsivity and contextual variations. Further research is warranted to unravel the distinctive features of contextual processing in opioid- vis-à-vis alcohol addiction and how these features may interrelate in comorbid conditions.

Comparative analysis of original face and skin-warped average face images for the scoring of skin attributes.

Representative of a panel, an average face image could be used to analyse/display skin changes while alleviating image rights constraints. Therefore, we used landmark-based deformation (warping) of individual skin images onto their panel's average face, evaluating this approach's relevance and possible limits. An average front face image was constructed from images of 71 Japanese women (50-60 years old). After warping individual skin images onto this average face, the resulting skin-warped average faces were presented to three experts who graded: forehead wrinkles, nasolabial fold, wrinkle of the corner of the lips, pore visibility and skin pigmentation homogeneity. Two experts estimated subjects' age. Results were compared to gradings performed on original images. Inter-expert grading shows excellent to good correlation whatever image type: from 0.918 (forehead wrinkles) to 0.693 (visibility of pores). Correlations between scoring of both image types are almost always higher than inter-expert correlations (maximum: 0.939 for forehead wrinkles-minimum: 0.677 for pore visibility). Frequencies of grades/ages are similar when scoring original and skin-warped average face images. Experts scores are similar in 90.6%-99.3% of the cases. Average deviations upon scoring both image types are smaller than average inter-expert deviations on original images. Scoring facial characteristics in original images and skin-warped average face images show an excellent agreement, even for perceived age, a complex feature. This opens the possibility of using this approach to grade facial skin features, monitor changes over time, and to valorise results on a face deprived of image rights.

Widespread Emphysema After Elective Colonoscopy

CASE REPORT Perforation in colonoscopy occurs in 5.8 procedures per 10,000,1 and 52% are detected within 1 hour.2 Common signs include subcutaneous emphysema of the face, neck, or upper chest,3 but the growing complexity and demand for colonoscopy increase the incidence and severity of complications. A 72-year-old man with a medical history of pneumoconiosis and colorectal cancer status post right hemicolectomy complicated by anastomotic leakage resulting in temporary diverting ileostomy presented for colon cancer surveillance and precolonic reconstruction evaluation. One year before, the patient was submitted to right hemicolectomy for colon cancer therapy. As early surgical anastomosis leakage occurred, a temporary diverting ileostomy was performed. Ten minutes after colon inflation with room air, the patient became hemodynamically unstable witch precluded the polypectomy. Computed tomography showed subcutaneous emphysema (Figure 1), pneumoretroperitoneum (Figure 2), pneumothorax, pneumopericardium (Figure 3), and extra peritoneum fistula (Figure 4).Figure 1.: (A) Facial subcutaneous emphysema after intubation and (B) normal face at discharge.Figure 2.: Computed tomography abdomen: pneumoperitoneum and pneumoretroperitoneum.Figure 3.: Computed tomography chest: bilateral pneumothorax and pneumopericardium.Figure 4.: Abdominal wall with ileostomy bag in place. White arrow: extra peritoneum fistula.Anatomical alterations resulting from past abdominal surgeries favored gas spreading through the fistula. Positive pressure ventilation and lung disease led to hypertensive pneumothorax generating hemodynamic instability. The use of low solubility room air and the ileostomy bag acted as emphysema catalyzers. To prevent life-threatening complications, it is important to know the underlying pathophysiological framework, the patient's risk factors, and adapt to each individual patient. DISCLOSURES Author contributions: AM Pinto: writing of the manuscript and literature review, and is the article guarantor. P. Sarrmento, A. Fonte, and R. Cerqueira: literature review, review of intellectual content, and manuscript final approval. Financial disclosure: None to report. Informed consent was obtained for this case report.

3D-CariGAN: An End-to-End Solution to 3D Caricature Generation from Normal Face Photos.

Caricature is a kind of artistic style of human faces that attracts considerable attention in entertainment industry. So far a few 3D caricature generation methods exist and all of them require some caricature information (e.g., a caricature sketch or 2D caricature) as input. This kind of input, however, is difficult to provide by non-professional users. In this paper, we propose an end-to-end deep neural network model that generates high-quality 3D caricature directly from a simple normal face photo. The most challenging issue in our system is that the source domain of face photos (characterized by 2D normal faces) is significantly different from the target domain of 3D caricatures (characterized by 3D exaggerated face shapes and texture). To address this challenge, we (1) build a large dataset of 6,100 3D caricature meshes and use it to establish a PCA model in the 3D caricature shape space, (2) reconstruct a 3D normal full head from the input face photo and use its PCA representation in the 3D caricature shape space to set up correspondence between the input photo and 3D caricature shape, and (3) propose a novel character loss and a novel caricature loss based on previous psychological studies on caricatures. Experiments including a novel two-level user study show that our system can generate high-quality 3D caricatures directly from normal face photos.

What is the prevalence of developmental prosopagnosia? An empirical assessment of different diagnostic cutoffs.

The prevalence of developmental prosopagnosia (DP), lifelong face recognition deficits, is widely reported to be 2-2.5%. However, DP has been diagnosed in different ways across studies, resulting in differing prevalence rates. In the current investigation, we estimated the range of DP prevalence by administering well-validated objective and subjective face recognition measures to an unselected web-based sample of 3116 18-55 year-olds and applying DP diagnostic cutoffs from the last 14 years. We found estimated prevalence rates ranged from .64-5.42% when using a z-score approach and .13-2.95% when using a percentile approach, with the most commonly used cutoffs by researchers having a prevalence rate of .93% (z-score, .45% when using percentiles). We next used multiple cluster analyses to examine whether there was a natural grouping of poorer face recognizers but failed to find consistent grouping beyond those with generally above versus below average face recognition. Lastly, we investigated whether DP studies with more relaxed diagnostic cutoffs were associated with better performance on the Cambridge Face Perception Test. In a sample of 43 studies, there was a weak nonsignificant association between greater diagnostic strictness and better DP face perception accuracy (Kendall's tau-b correlation, τb=.18 z-score; τb=.11 percentiles). Together, these results suggest that researchers have used more conservative DP diagnostic cutoffs than the widely reported 2-2.5% prevalence. We discuss the strengths and weaknesses of using more inclusive cutoffs, such as identifying mild and major forms of DP based on DSM-5.

Local Eyebrow Feature Attention Network for Masked Face Recognition

During the COVID-19 coronavirus epidemic, wearing masks has become increasingly popular. Traditional occlusion face recognition algorithms are almost ineffective for such heavy mask occlusion. Therefore, it is urgent to improve the recognition performance of the existing face recognition technology on masked faces. Due to the limited visible feature points of the masked face image relative to the normal face image, we have to exploit the identification potential of eyebrow (referring to eyes and brows) features. This article proposes a local eyebrow feature attention network for masked face recognition, which consists of feature extraction, eyebrow region pooling, and feature fusion. To highlight the eyebrow region, we first use the eyebrow region pooling to separate the local features of eyebrows from the learned overall facial features. We then make full use of the symmetry of left and right eyebrows to emphasize their discriminant ability, due to the inadequate fine information of the low-resolution eyebrows. In particular, in view of the symmetrical similarity between eyebrow pairs and the subordinate relationship between facial components and the whole, we propose a feature fusion model based on graph convolutional network (GCN) to learn the feature association structure of eye features, brow features, and global facial features. We construct the benchmark datasets for masked face recognition to validate our approach, including real-world masked face recognition dataset (RMFRD) and synthetic masked face recognition dataset (SMFRD). Extensive experimental results on both public datasets and our built masked face datasets show that our approach significantly outperforms the state-of-the-arts.

Facial Anthropometric Analysis of a Representative Subset in an Average Kerala Population: A Pilot Study.

Background The Neoclassical canons, originally framed based on the Renaissance artworks, vary across genders, races, and ages. This has been proved in multiple studies conducted on the Western population, but minimal studies exist on the Eastern population and lesser so on the Indian population. This study aims to define the standard Keralite face and assess its variation from the canons. Methods A total of 250 people of Kerala origin aged 18 to 40 years were studied over a period of 1 year in our institute. Standardized frontal and profile photographs of the subjects were taken. Twenty anthropometric measurements were taken and analyzed for variation between genders, from published Indian standards and their conformity to the Neoclassical canons. Results Compared to the Keralite men, there were significant differences in 14 of 19 measurements in Keralite women. The men had wider and longer faces than women. Five of 10 measurements in females and 6 of 10 measurements in males significantly differed from the published Indian norms. The average Keralite face was wider, longer, and rounder. None of the facial proportions fit the Neoclassical canons. Conclusion The average Keralite face significantly differed from the Neoclassical canons and there were some significant variations between genders. This study highlights the need for a larger population-based study with more representation from various regions across India.

Literature Review: Analysis Of Students' Cognitive Style And Affection In Strengthening Essay Writing Malay Language In Primary School

This study aims to analyze the student's cognition and affective styles in Malay essay writing. The study sample involved 40 Year 5 students to be interviewed and 2 teachers to be interviewed. A total of 40 original student written texts were studied and analyzed and 12 students were interviewed to obtain data and transcribed into study texts. The text of this study was analyzed using the Hermeneutic method to interpret the study findings. The findings of the study show that excellent and good students can apply the style of cognition, affect and past experience in essay writing while average students face difficulties in practicing the style of cognition, affect and past experience in essay writing. In conclusion, affect as an internal element helps generate knowledge among students. Affective reactions can develop students cognitively to produce a good essay. When the affective reaction is disrupted, the failure to extract information about an essay title from the student's subconscious will affect the student's thinking. The implication of this study for students and teachers is to be able to realize the importance of affective and cognitive styles in writing karanagan BM whether in the excellent, good, and average categories.

PHIP-associated Chung-Jansen syndrome: Report of 23 new individuals.

In 2016 and 2018, Chung, Jansen and others described a new syndrome caused by haploinsufficiency of PHIP (pleckstrin homology domain interacting protein, OMIM *612,870) and mainly characterized by developmental delay (DD), learning difficulties/intellectual disability (ID), behavioral abnormalities, facial dysmorphism and obesity (CHUJANS, OMIM #617991). So far, PHIP alterations appear to be a rare cause of DD/ID. "Omics" technologies such as exome sequencing or array analyses have led to the identification of distinct types of alterations of PHIP, including, truncating variants, missense substitutions, splice variants and large deletions encompassing portions of the gene or the entire gene as well as adjacent genomic regions. We collected clinical and genetic data of 23 individuals with PHIP-associated Chung-Jansen syndrome (CHUJANS) from all over Europe. Follow-up investigations (e.g. Sanger sequencing, qPCR or Fluorescence-in-situ-Hybridization) and segregation analysis showed either de novo occurrence or inheritance from an also (mildly) affected parent. In accordance with previously described patients, almost all individuals reported here show developmental delay (22/23), learning disability or ID (22/23), behavioral abnormalities (20/23), weight problems (13/23) and characteristic craniofacial features (i.e. large ears/earlobes, prominent eyebrows, anteverted nares and long philtrum (23/23)). To further investigate the facial gestalt of individuals with CHUJANS, we performed facial analysis using the GestaltMatcher approach. By this, we could establish that PHIP patients are indistinguishable based on the type of PHIP alteration (e.g. missense, loss-of-function, splice site) but show a significant difference to the average face of healthy individuals as well as to individuals with Prader-Willi syndrome (PWS, OMIM #176270) or with a CUL4B-alteration (Intellectual developmental disorder, X-linked, syndromic, Cabezas type, OMIM #300354). Our findings expand the mutational and clinical spectrum of CHUJANS. We discuss the molecular and clinical features in comparison to the published individuals. The fact that some variants were inherited from a mildly affected parent further illustrates the variability of the associated phenotype and outlines the importance of a thorough clinical evaluation combined with genetic analyses for accurate diagnosis and counselling.

Influence of Coal Mining on Historical Buildings: Case Study in Shanxi

Numerous historical buildings exist in Shanxi Province, a major coal producing area in China, so there exist many overlapping areas between ancient wooden buildings and coal mining. Coal mining in overlapping areas will lead to surface subsidence, which will have an impact on historical buildings. Based on the distribution of historical buildings and the distribution and mining of coal resources in Shanxi Province, this paper concludes that the overlapping areas of coal mining and ancient wooden buildings in Shanxi Province are mainly concentrated in Changzhi City, and the Lu'an mining area in Changzhi City is selected as the research object. In addition, using the gray correlation analysis method, the surface subsidence coefficient, which characterizes the intensity of mining subsidence, is used as the reference sequence. Seven factors selected from the geological conditions and mining conditions of the Lu'an mining area are used as the comparison sequence to calculate the gray correlation between each influencing factor and the surface subsidence coefficient, and to obtain that geological factors such as the nature of the overlying rock layer, bedrock thickness and dip angle of the coal seam, and mining factors such as mining height, average mining depth and working face size largely determine the surface subsidence coefficient. The surface subsidence in the overlap area could largely be influenced by geological factors such as the nature of the overlying rock layer, bedrock thickness and coal seam inclination, and mining factors such as mining height, average mining depth and working face size. Finally, we investigate the possible effects of surface subsidence on ancient wooden buildings in the overlapping area with the surface subsidence and formation mechanism and propose technical measures to reduce the effects of surface subsidence due to coal mining on historical buildings in the overlapping area.

FMRI evidence that hyper-caricatured faces activate object-selective cortex.

Many brain imaging studies have looked at the cortical responses to object categories and faces. A popular way to manipulate face stimuli is by using a "face space," a high dimensional representation of individual face images, with the average face located at the origin. However, how the brain responds to faces that deviate substantially from average has not been much explored. Increasing the distance from the average (leading to increased caricaturing) could increase neural responses in face-selective regions, an idea supported by results from non-human primates. Here, we used a face space based on principal component analysis (PCA) to generate faces ranging from average to heavily caricatured. Using functional magnetic resonance imaging (fMRI), we first independently defined face-, object- and scene-selective areas with a localiser scan and then measured responses to parametrically caricatured faces. We also included conditions in which the images of faces were inverted. Interestingly in the right fusiform face area (FFA), we found that the patterns of fMRI response were more consistent as caricaturing increased. However, we found no consistent effect of either caricature level or facial inversion on the average fMRI response in the FFA or face-selective regions more broadly. In contrast, object-selective regions showed an increase in both the consistency of response pattern and the average fMRI response with increasing caricature level. This shows that caricatured faces recruit processing from regions typically defined as object-selective, possibly through enhancing low-level properties that are characteristic of objects.

The average three-dimensional face for different sex and age groups in a Dutch population

The increasing use of three-dimensional imaging calls for reference models representing large parts of the population. The aim of this prospective study was to create templates depicting facial maturation in the younger age groups. Healthy Dutch volunteers were captured, without selection of inclusions. Three-dimensional average faces were created using MATLAB, for both genders in four age groups (4–8 years, 8–12 years, 12–16 years, and ≥16 years). Variation within the groups was calculated and depicted on an average face with a green to red colour scale, corresponding to standard deviations between 0 and ≥ 3 mm, respectively. Measurements of the distances of eight peri-oral landmarks were provided as ratios. The statistical analysis was performed using ANOVA and Tukey’s test. Three-dimensional reconstructions of the average face and their first principal component were created for each gender and age group. The first principal component comprised the facial width for each group, and the variation of landmarks was low. All ratios showed an increasing trend with increasing age, except for the ratio of philtrum width to mouth width. This study is novel in comparing facial morphology by means of ratios and in creating average faces for the different young age groups. These data provide useful insights into facial maturation, which might be beneficial for facial surgeons.

Development of bits for directional drilling in complex mining and geological conditions

The purpose of the study is to improve the efficiency of directional drilling using continuous whipstocks in difficult mining and geological conditions. The research involves the description of mining and geological conditions featuring decreased efficiency of continuous whipstock operation as well as the reasons why the decrease is observed. It should be noted that significant problems arise when using the milling-type continuous whipstocks for sidetracking in hard rocks from the plug back total depths of cement mixtures and well deviations in the intervals of normal face weakened rocks. In this case, there is a decrease in deviation accuracy, due to the increased sinking speed that prevents curvature accumulation and which is difficult to control by the drilling mode parameters. Another problem that decreases the well deviation accuracy when using milling-type whipstocks in hard rocks is the deviation of the drift angle build up plane due to the disorienting force that occurs during milling of the borehole wall. The study briefly dwells upon the existing technologies and engineering means, the use of which is aimed at improving the whipstock performance in complex mining and geological conditions, including through the use of bits with a special design. The author has proposed and patented a series of new technical means (bits) and technological solutions that effectively deal with the drop in the performance of continuous whipstocks in the well deviated in hard rocks. Moreover, the developed means took into account the shortcomings of current technical equipment.

The Facial Width-To-Height Ratio is Unrelated to Aggressive Behaviour in Indonesian People

As a channel of non-verbal communication, faces can give information such as mate attraction, intelligence, and aggressivity. Aggressivity is a character to dominate, protect position, and fight over resources. Several aggressive behaviours in humans are, for example, anger, hostility, physical aggression, and verbal aggression. Previous studies in western society showed that aggressivity could be perceived from the faces. We tested 100 Indonesian males ranging from 19-51 years old to fill out the Buss-Perry Aggression Questionnaire (BPAQ) to measure the aggression scale. The mean of their BPAQ scales (total aggression, anger, hostility, physical aggression, and verbal aggression) were 72.44±10.84, 17.37±3.97, 21.38±4.53, 18.97±4.65, 14.72±2.68, respectively. The average facial photograph was generated based on the min-Q1 (Low Aggressivity (LA)) and Q3-max (High Aggressivity (HA)) BPAQ scale. Next, the aggressivity of averaged LA and HA faces was evaluated by raters. The raters consisted of 145 males and 213 females randomly recruited, ranging from 17 to 67 years old. The facial width-to-height (fWHR) ratio between the average faces of the Low-Aggression face and the High-Aggression face was insignificant. This study concluded that Indonesian people could not perceive aggressivity in their faces.

Novel and recurrent COMP gene variants in five Japanese patients with pseudoachondroplasia: skeletal changes from the neonatal to infantile periods.

Pseudoachondroplasia (PSACH) is an autosomal dominant skeletal dysplasia caused by pathogenic variants of cartilage oligomeric matrix protein (COMP). Clinical symptoms of PSACH are characterized by growth disturbances after the first year of life. These disturbances lead to severe short stature with short limbs, brachydactyly, scoliosis, joint laxity, joint pain since childhood, and a normal face. Epimetaphyseal dysplasia, shortened long bones, and short metacarpals and phalanges are common findings on radiological examination. Additionally, anterior tonguing of the vertebral bodies in the lateral view is an important finding in childhood because it is specific to PSACH and normalizes with age. Here, we report five Japanese patients with PSACH, with one recurrent (p.Cys351Tyr) and four novel heterozygous pathogenic COMP variants (p.Asp437Tyr, p.Asp446Gly, p.Asp507Tyr, and p.Asp518Val). These five pathogenic variants were located in the calcium-binding type 3 (T3) repeats. In four of the novel variants, the affected amino acid was aspartic acid, which is abundant in each of the eight T3 repeats. We describe the radiological findings of these five patients. We also retrospectively analyzed the sequential changes in the vertebral body and epimetaphysis of the long bones from the neonatal to infantile periods in a patient with PSACH and congenital heart disease.