In order to accurately predict the gas concentration, find out the gas abnormal emission in advance, and take effective measures to reduce the gas concentration in time, this paper analyzes multivariate monitoring data and proposes a new dynamic combined prediction method of gas concentration. Spearman's rank correlation coefficient is applied for the dynamic optimization of prediction indicators. The time series and spatial topology features of the optimized indicators are extracted and input into the combined prediction model of gas concentration based on indicators dynamic optimization and Bi-LSTMs (Bi-directional Long Short-term Memory), which can predict the gas concentration for the next 30 min. The results show that the other gas concentration, temperature, and humidity indicators are strongly correlated with the gas concentration to be predicted, and Spearman's rank correlation coefficient is up to 0.92 at most. The average R2 of predicted value and real value is 0.965, and the average prediction efficiency R for gas abnormal or normal emission is 79.9%. Compared with the other models, the proposed dynamic optimized indicators combined model is more accurate, and the missing alarm of gas abnormal emission is significantly alleviated, which greatly improves the early alarming accuracy. It can assist the safety monitoring personnel in decision making and has certain significance to improve the safety production efficiency of coal mines.