Introduction: Patients with Primary biliary cholangitis (PBC) are at increased risk of developing Hepatocellular carcinoma (HCC). Studies report that risk factors for HCC in PBC include male sex and advanced histologic stage. We aim to describe the occurrence and outcomes of HCC in our population of PBC patients. Methods: Clinical data from 114 patients with primary biliary cholangitis seen at our center between January 1, 2006 and December 31, 2017 was retrospectively reviewed for occurrence of HCC and factors associated with this occurrence. Results: Seven patients with PBC developed HCC (6.1%). Baseline characteristics are listed in Table 1. Median mass size was 2.95 cm (1.3-2.6 cm) and median Alpha Fetoprotein (AFP) was 3.05 (2.4-1366 ng/ml). Five patients underwent liver transplantation. The two patients that were not transplanted underwent Transcatheter arterial chemoembolization (TACE). Median time to liver transplantation from diagnosis of PBC was 13 years (7 to 24 years). No patients had recurrence of PBC after liver transplantation. Conclusion: The occurrence of HCC in our patient population is congruent with that reported in prior studies. Although male sex has also been linked to increased occurrence of HCC in PBC, our patients who developed HCC were all females. AFP levels are commonly used to screen for HCC, however, most patients (75%) in our study with PBC who developed HCC had a normal AFP level. It is worth noting that all the patients who developed HCC in our cohort were non-responders to UDCA.2842 Figure 1. No Caption available.