Abstract A partially shaded photovoltaic (PV) array's characteristic curve is convoluted due to disparity in irradiance levels between shaded and unshaded PV panels, resulting in power mismatch losses. This work presents a new hybrid approach combining the Magic Square (MS) array configuration and Differential Evolution based adaptive perturb and observe (DEAPO) MPPT methodology to overcome the abovementioned problem. The proposed hybrid methodology is implemented in two steps: first, repositioning the PV panels as per the MS configuration to decrease the power losses of partial shading. In MS configuration, the concentrated shadow on a single row or column can spread over to the entire PV array equally without any physical or electrical switching of PV panels. Second, the DEAPO MPPT method is developed to find the global peak power point on the PV characteristic curve. PID controller coefficients are optimized by DE to enhance the tracking speed and convergence of the adaptive P&O MPPT. The simulation study of this work has been implemented using PV arrays in MATLAB/SIMULINK environment and the real-time validation is done through a 5 kW PV array. The proficiency of the proposed hybrid approach is tested by creating various non-uniform and uniform shading patterns on the PV array. The simulation and experimental results prove that the proposed hybrid approach increases the power output by 19% and 20% higher than the existing Total Cross Tie (TCT) configuration under non-uniform and uniform shading cases respectively.