Nonsuppurative Panniculitis Research Articles

Imaging of idiopathic nonsuppurative nodular panniculitis of breast.

Imaging of idiopathic nonsuppurative nodular panniculitis of breast.

Weber-Christian disease: ultrasound can see it

Weber-Christian disease, also known as idiopathic relapsing febrile nodular non-suppurative panniculitis, is a rare inflammatory disorder of the subcutaneous tissue characterized by recurrent nodules often associated with constitutional symptoms, in particular pain and fever. A 50-year-old female patient underwent ultrasound examination of the soft tissues because of relapsing painful subcutaneous nodules of the left arm, accompanied by fever. Ultrasonography showed subcutaneous nodules suggestive of panniculitis. An ultrasound-guided biopsy was performed. The ultrasound-guided biopsy from the nodules with mixed echostructure revealed lobular panniculitis with a mixed cell infiltrate, consistent with Weber-Christian disease, after clinical and pathological exclusion of several differential diagnoses. Recurrent painful subcutaneous nodules associated with fever necessitate a careful medical history and thorough physical examination. Ultrasound can be useful to formulate the hypothesis of panniculitis. Histological examination of a ultrasound-guided biopsy of a nodule with mixed echostructure is needed to confirm the diagnosis. Weber-Christian disease remains a diagnosis of exclusion, when no other cause for the lobular panniculitis can be identified.

Efficacy of cyclosporine A treatment in relapsing febrile lobular panniculitis associated with small vessel vasculitis

Weber-Christian Disease (WCD), also known as relapsing febrile lobular non-suppurative panniculitis, is a rare condition characterized by recurrent subcutaneous inflammatory nodules in the adipose tissue in addition to fever, malaise and other systemic manifestations such as polyarthralgia and polymyalgia. The association with small vessel vasculitis has been rarely reported. We report here an unusual case of WCD associated with small vessels vasculitis also describing the efficacy of Cyclosporin A treatment.

The men behind the eponym: Frederick Parkes Weber and Henry a. Christian: Weber-Christian disease.

Frederick Parkes Weber described relapsing nonsuppurative panniculitis in 1925. In 1928, Henry Asbury Christian added the word "febrile" (relapsing febrile nodular nonsuppurative panniculitis), whereas Brill first coined the eponym "Weber-Christian disease" in 1936. This article traces the lives of Parkes Weber and Henry Christian and summarizes their original publications. It addresses only briefly the controversy as to whether Weber-Christian disease does or does not exist.

Ｃｙｔｏｐｈａｇｉｃ ｈｉｓｔｉｏｃｙｔｉｃ ｐａｎｎｉｃｕｌｉｔｉｓと考えられる１剖検例

A case of cytophagic histiocytic panniculitis (CHP) occurring in a 15-year-old Japanese male is reported. The patient presented with typical fever, painful subcutaneous nodules, liver dysfunction, proteinuria, leukopenia, and coagulopathy shortly after sustaining a blunt trauma to the face, and died 6 months later due to severe hemor rhagic diathesis. Skin biopsy shortly after the onset revealed nonsuppurative lobular panniculitis with active proliferation of histiocytes in inflamed fat. Autopsy revealed systemic nonsuppurative panniculitis as well as proliferation of hemophagocytic histiocytes in inflamed areas and the reticuloendothelial system. Immunological studies suggest autoimmune etiology of CHP. Activation and proliferation of histiocytes may be caused by various lipid molecules released from inflamed adipose tissue, and coagulopathy of CHP may at least partly be caused by direct action of activated histiocytes on certain coagulation factors.

広範な下がく骨骨髄炎を併発したＷｅｂｅｒ‐Ｃｈｒｉｓｔｉａｎ病の１例

A rare case of Weber-Christian disease (generalized nonsuppurative panniculitis) is reported which is accompanied with bone interference of extremity and widespread rodent appearance of mandible.

Necrobiosis Lipoidica Associated With Jejunoileal Bypass Surgery

A variety of cutaneous disorders has been reported after jejunoileal bypass surgery for the treatment of morbid obesity. A vesiculopustular eruption is most frequently described, but alopecia, erythema nodosum, urticaria, angioedema, and nodular nonsuppurative panniculitis have also been reported.^1-4We report herein a case of necrobiosis lipoidica that developed after small-bowel bypass surgery and rapidly resolved after reanastomosis. <h3>Report of a Case</h3> A 41-year-old woman was referred to us for examination of two leg lesions of 18 months' duration. The patient denied any antecedent trauma. The biopsy specimen that had been taken 11 months before her evaluation at this center had been interpreted diagnostically as necrobiosis lipoidica. Further examination of the patient at the time of biopsy included a serologic test for syphilis, complete blood cell count, chemistry panel, chest roentgenogram, and an oral glucose tolerance test. All of these test results were normal or negative. Use of topical,

Nodular Nonsuppurative Panniculitis Associated With Jejunoileal Bypass Surgery

A 32-year-old woman underwent jejunoileal bypass surgery for morbid obesity. Her postoperative course was marked with many of the complications of this type of surgery. In addition, tender, erythematous nodules developed on her legs and abdomen that were grossly and microscopically consistent with nodular nonsuppurative panniculitis. She did not have any condition or disease previously reported to be associated with nodular nonsuppurative inflammation. The nodular panniculitis in this patient appears to be a new complication of small-bowel bypass surgery.

Nodular nonsuppurative panniculitis associated with jejunoileal bypass surgery

Nodular nonsuppurative panniculitis associated with jejunoileal bypass surgery

Generalized proteolysis in a young woman with Weber-Christian disease (nodular nonsuppurative panniculitis).

A patient with Weber-Christian disease (syn. nodular nonsuppurative panniculitis) is reported. The generalized cellular destruction in this patient resulted in liberation of proteolytic enzymes into the circulation, which led to multiple haemostatic disturbances with haemorrhagic diathesis. The most prominent haemostatic defects were thrombocytopenia with a normal life span of isologous platelets, high levels of AHF-related antigen, hypofibronigenaemia with short fibrinogen survival, low levels of Factor XIII (fibrin stabilizing factor = FSF) and increased amounts of fibrin/fibrinogen degradation products (FDP). Proteolytic enzymes, other than thrombin and plasmin which especially degrade Factor XIII and fibrongen, derived from destroyed cells (probably leukocytes) seem to have been involved in the pathogenesis of the bleeding disorder in this patient.

"Yellow fat disease" (pansteatitis) in wild hares in New Zealand.

Abstract Extract “Yellow fat disease” is a disease of certain species of animals, characterized macroscopically by greyish-yellow discoloration and microscopically by inflammatory and degenerative reactions and the occurrence of a characteristic acid-fast pigment in the fat tissue. The terms “nonsuppurative panniculitis”, “pansteatitis”, or “yellow ear disease (chinchilla)” are synonyms.

Weber-Christian disease. Report of a case documenting the presence of leukoagglutinins.

Weber-Christian disease is the eponymous designation of an idiopathic, relapsing, febrile, nodular, and nonsuppurative panniculitis. The presence of leukoagglutinins in the absence of a transfusion history and the peculiar response to intradermal injection of an autologous buffy coat tend to support the contention that this disease may constitute merely a histiologically specific, hyperergic response.

Weber-Christian Disease

Weber-Christian disease is the eponymous designation of an idiopathic, relapsing, febrile, nodular, and nonsuppurative panniculitis. The presence of leukoagglutinins in the absence of a transfusion history and the peculiar response to intradermal injection of an autologous buffy coat tend to support the contention that this disease may constitute merely a histiologically specific, hyperergic response.

Panniculitis, Vasculitis, and a Positive Lupus Erythematosus Cell Test

RELAPSING, nodular, nonsuppurative panniculitis is rare and of unknown etiology. It is characterized by fever (87% of cases)¹and spontaneous appearance of subcutaneous nodules on the extremities or trunk. The following have been suggested as possible causes of subcutaneous, nodular panniculitis²: halogen compounds, infections (especially tuberculosis), trauma, faulty fat metabolism, drug ingestion, and antigen-antibody reactions.³Cases of migratory, nonsuppurative panniculitis have also been reported in association with rheumatoid arthritis,^4,5erythema nodosum,⁵dermatomyositis,⁵and sarcoid.⁶Thus it has been suggested that migratory nodular panniculitis is related to collagen disorders. The following report is an interesting case of afebrile, nodular, nonsuppurative panniculitis in a patient with positive lupus erythematosus (LE) cell tests, ulcerative colitis, erythema nodosum, and small-vessel vasculitis. <h3>Report of a Case</h3> A 40-year-old widow (197854) entered the Mount Auburn Hospital for the ninth time on July 23, 1965 complaining of lumps on all

Factitial Weber-Christian Syndrome

A unique psychocutaneous syndrome characterized by relapsing febrile nodular nonsuppurative panniculitis was seen in a teenage girl. Her disease, thought to be Weber-Christian syndrome clinically and pathologically, was eventually discovered to be caused by self-injections of milk. The bizarre pattern of typical factitial dermatitis is easily recognized, but exceptional cases may closely resemble authentic disease. Although factitial dermatitis may be associated with many different psychiatric conditions, the highest suspicion should be reserved for the hysterical personality. The characteristic behavior of the hysterical personality can alert the clinician to the possibility of factitial dermatitis.

X-RAY SIGN IN WEBER-CHRISTIAN DISEASE.

WEBER-CHRISTIAN DISEASE, more descriptively known as relapsing, febrile, nodular, nonsuppurative panniculitis, is characterized by recurrent tender inflammatory nodules in the subcutaneous fat. Internal fat deposits may also be involved. Many excellent reviews of this syndrome have appeared in the literature in recent years.^1-6It is of interest to note that, in many of the patients described,¹rheumatic fever or some other rheumatic disease had at one time or another been diagnosed. Similarly, for the patient described in this report the diagnosis of rheumatic fever had been made on three widely separate occasions. During a recent episode of panniculitis this patient presented with a severely swollen, red, warm, painful knee. X-rays of the knee revealed changes which we feel are helpful in establishing the diagnosis of Weber-Christian disease. Although x-ray visualization of calcification within the necrotic subcutaneous fat nodules has been described in this condition, we have found no

SUBACUTE NODULAR MIGRATORY PANNICULITIS.

Nodules of the legs are often difficult diagnostic problems. The clinical patterns may be similar in erythematous nodules of widely varying causation, and biopsy of the lesions may reveal a nonspecific pattern of acute or chronic inflammation involving dermis, vessels, or fat. In the consideration of chronic inflammatory lesions one should keep several conditions in mind. These include erythema induratum, nodular vasculitis, and erythema nodosum; conditions in which the vessels are primarily involved, such as periarteritis nodosa and migratory thrombophlebitis; and finally those in which the panniculus is primarily involved, namely febrile relapsing nodular nonsuppurative panniculitis (Weber-Christian disease) and lipogranulomatosis subcutanea of Rothmann and Makai. In 1956, Vilanova and Aguade1described subacute nodular migratory panniculitis and emphasized its features that led them to believe that it is a distinct and independent entity. Additional reports by these authors and others confirm the impression that this is a specific clinical syndrome.

Frederick Parkes Weber—1863-1962

F PARKES WEBER (Figs 1 and 2) died June 2 in his 100th year. 1 He distinguished himself in medicine as a keen observer and as an eagerly curious and tireless student of disease, particularly the unusual. Few others, if any, have given their name to so many diseases. The three best known of the Weber eponyms are: (1) Osler-Rendu-Weber's hereditary hemorrhagic telangiectasia 2 ; (2) Sturge-Weber disease 3 —hemangiectatic nevus of the face and cerebral meninges; and (3) Weber-Christian disease 4 —relapsing febrile nodular nonsuppurative panniculitis. But others are the Weber-Klippel syndrome 5-7 — hemangiectatic hypertrophy of the limbs (see Fig 3 for an example); Vaquez-Osler-Weber disease 8,9 —polycythemia vera with splenomegaly; Weber-Cockayne familial recurrent bullous eruption of the hands and feet, 10 which is a form of localized epidermolysis bullosa. 11,12 Weber's voluminous writings, numbering over 1,200, began in 1890 with a paper on abnormal foramina in the

Chloroquine diphosphate therapy in Weber-Christian syndrome.

Case Reports1 October 1959CHLOROQUINE DIPHOSPHATE THERAPY IN WEBER-CHRISTIAN SYNDROMEWALTER K. MYERS, M.D., F.A.C.P.WALTER K. MYERS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-4-791 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRelapsing febrile nodular nonsuppurative panniculitis (Weber-Christian syndrome) has been recognized with increased frequency. Little is known concerning its etiology. No specific therapy has been available.Two cases of Weber-Christian syndrome are reported. The responses to chloroquine diphosphate were quite dramatic and gratifying.CASE REPORTSCase 1. A white woman was first seen in May, 1947, when she was 40 years of age. For five years she had had recurrent attacks of painful, tender nodules in the calves of the legs and in the left thigh. Walking and standing gave rise to symptoms varying from discomfort to severe pain. On three...Bibliography1. AldersonWay HESC: Relapsing febrile nonsuppurative panniculitis (Weber), Arch. Dermat. and Syph. 27: 440, 1933. CrossrefGoogle Scholar2. Bailey RJ: Relapsing, febrile, nonsuppurative panniculitis (Weber-Christian disease), J. A. M. A. 109: 1419, 1937. CrossrefGoogle Scholar3. De LoiMartz CJRW: Weber-Christian disease with bone involvement, Ann. Int. Med. 43: 591, 1955. LinkGoogle Scholar4. HansonFowler WALH: Relapsing febrile nodular nonsuppurative panniculitis, Minnesota Med. 24: 779, 1951. Google Scholar5. Andrews GC: Diseases of the skin, 1954, W. B. Saunders Company, Philadelphia, p. 547. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication May 12, 1958.From the Departments of Medicine, The George Washington University School of Medicine and The Washington Medical Center, Washington, D. C.Requests for reprints should be addressed to Walter K. Myers, M.D., 1834 Eye Street, Northwest, Washington 6, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySuccessful Treatment of Idiopathic Febrile Panniculitis (Weber-Christian Disease) with Thalidomide in a Patient Having Failed Multiple Other Medical TherapiesChloroquine-induced remission of nodular panniculitis present for 15 yearsWeber-Christian disease with facial involvementA case of Weber-Christian disease with roentgenographically demonstrable mammary calcificationsRheumatism and Arthritis Review of American and English Literature of Recent Years (Fourteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., CHARLES L. CHRISTIAN, M.D., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., EDWARD C. FRANKLIN, M.D., DONALD F. HILL, M.D., F.A.C.P., JOSEPH L. HOLLANDER, M.D., F.A.C.P., HOWARD L. HOLLEY, M.D., F.A.C.P., JOHN G. MAYNE, M.D., WILLIAM M. MIKKELSEN, M.D., CHARLES L. SHORT, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P.(C), OTTO STEINBROCKER, M.D., HOWARD J. WEINBERGER, M.D. 1 October 1959Volume 51, Issue 4Page: 791-795KeywordsChloroquineEtiologyLesionsWalking ePublished: 1 December 2008 Issue Published: 1 October 1959 PDF downloadLoading ...

Co-existence of joint symptoms and non-suppurative panniculitis: a clinical and histo-pathological study.

SummaryDuring a short period, 13 cases of simultaneously appearing joint symptoms and dermal changes, the latter often primarily regarded as erythema nodosum, were observed. The course of the disease and the anatomic nature of the dermal changes — a panniculitis — are described. Various etiologic factors are discussed. The cases in some respects resembled Parkes Weber-Christian's syndrome, in other respects the benign and more common Rothmann-Makai's panniculitis syndrome, to which they are referred here. The border between these two panniculitis syndromes is probably floating.