The American College of Obstetricians and Gynecologists (ACOG) Task Force statement on Hypertension in Pregnancy recommends that clinicians withhold nonsteroidal anti-inflammatory medications in patients with postpartum hypertension. We sought to determine if there was a dose dependent association between Ibuprofen dose and blood pressures postpartum in those with preeclampsia with severe features. This was a planned secondary analysis of a prospective cohort study of consecutive term patients meeting diagnostic criteria for preeclampsia with severe features delivered at a single academic medical center. Ibuprofen dose, frequency and time of administration were collected during the postpartum course. Noninvasive measurements of systolic and diastolic blood pressures (NIBP) were used to calculate daily mean arterial pressure (MAP). Association between Ibuprofen dose and MAPs were estimated using parametric T-tests. Of the 335 patients in our analysis, 94% received Ibuprofen postpartum. For those that received Ibuprofen, there was no association between daily Ibuprofen dose and mean postpartum MAP (Figure). The median total dose of ibuprofen was 3g during the postpartum hospitalization. Patients who received more than 3g of ibuprofen had an average MAP of 100.5±9.1 mmHg, which did not differ significantly from those who received less than 3g (99.4±9.4 mmHg, p= 0.28). This relationship persisted across modes of delivery (Table). There is no association between postpartum ibuprofen use with standard dosing and mean arterial blood pressure in patients with preeclampsia with severe features.View Large Image Figure ViewerDownload Hi-res image Download (PPT)