A man in his 20s presented with complaints of diminution of vision in both eyes for the past 15 days. He had a history of carcinoma colon for which he underwent hemicolectomy 2 months ago. There was vitritis with white fluffy exudate lesion suggestive of infective foci along the superior arcade, which was noted on fundus examination. A provisional diagnosis of endogenous endophthalmitis was made in both eyes, and pars plana vitrectomy with cryotherapy of infective foci was done. The vision of patient improved at 1-week follow-up. However, it dropped at 1 month due to macular pucker formation at the site of cryotherapy. Cryotherapy should be used with caution in lesions away from the posterior pole and in recalcitrant, nonresolving lesions.