Non-related Pairs Research Articles

Effect of emoji prime on the understanding of emotional words – evidence from ERPs

ABSTRACT Emojis play an increasingly important role as nonverbal symbols in online communication, and this study investigates their effect on the processing of subsequent words. We suppose that emojis, as an aid to emotional expression and semantic comprehension, prime the cognitive processing of the textual stimuli that follow. An affective priming experiment using ERPs was conducted, in which Semantic Relationship between the emoji and the word (Congruent, Incongruent, Non-related) was manipulated to assess their impact in an affective word categorization task. Behavioral results revealed no significant difference, while electrophysiological data showed otherwise. N1 component elicited by semantically congruent and incongruent emoji-word pairs showed greater amplitudes than those by non-related pairs. N400 elicited by incongruent pairs showed greater amplitudes than the N400 by congruent pairs. These data indicate that while emojis do not influence the outcomes of linguistic processing, emoji primes enhance attentional level, and semantically congruent contents demand fewer cognitive resources and facilitate better processing in comparison to incongruent ones. The findings point to emojis’ role not only as affective primes, but also as paralanguage that is semantically processed. Implications for computer-mediated communication are discussed.

Joint Extraction of Multiple Relations and Entities from Building Code Clauses

The extraction of regulatory information is a prerequisite for automated code compliance checking. Although a number of machine learning models have been explored for extracting computer-understandable engineering constraints from code clauses written in natural language, most are inadequate to address the complexity of the semantic relations between named entities. In particular, the existence of two or more overlapping relations involving the same entity greatly exacerbates the difficulty of information extraction. In this paper, a joint extraction model is proposed to extract the relations among entities in the form of triplets. In the proposed model, a hybrid deep learning algorithm combined with a decomposition strategy is applied. First, all candidate subject entities are identified, and then, the associated object entities and predicate relations are simultaneously detected. In this way, multiple relations, especially overlapping relations, can be extracted. Furthermore, nonrelated pairs are excluded through the judicious recognition of subject entities. Moreover, a collection of domain-specific entity and relation types is investigated for model implementation. The experimental results indicate that the proposed model is promising for extracting multiple relations and entities from building codes.

In Silico Analysis of the Minor Histocompatibility Antigen Landscape Based on the 1000 Genomes Project.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is routinely used to treat hematopoietic malignancies. The eradication of residual tumor cells during engraftment is mediated by donor cytotoxic T lymphocytes reactive to alloantigens. In a HLA-matched transplantation context, alloantigens are encoded by various polymorphic genes situated outside the HLA locus, also called minor histocompatibility antigens (MiHAs). Recently, MiHAs have been recognized as promising targets for post-transplantation T-cell immunotherapy as they have several appealing advantages over tumor-associated antigens (TAAs) and neoantigens, i.e., they are more abundant than TAAs, which potentially facilitates multiple targeting; and unlike neoantigens, they are encoded by germline polymorphisms, some of which are common and thus, suitable for off-the-shelf therapy. The genetic sources of MiHAs are nonsynonymous polymorphisms that cause differences between the recipient and donor proteomes and subsequently, the immunopeptidomes. Systematic description of the alloantigen landscape in HLA-matched transplantation is still lacking as previous studies focused only on a few immunogenic and common MiHAs. Here, we perform a thorough in silico analysis of the public genomic data to classify genetic polymorphisms that lead to MiHA formation and estimate the number of potentially available MiHA mismatches. Our findings suggest that a donor/recipient pair is expected to have at least several dozen mismatched strong MHC-binding SNP-associated peptides per HLA allele (116 ± 26 and 65 ± 15 for non-related pairs and siblings respectively in European populations as predicted by two independent algorithms). Over 70% of them are encoded by relatively frequent polymorphisms (minor allele frequency > 0.1) and thus, may be targetable by off-the-shelf therapeutics. We showed that the most appealing targets (probability of mismatch over 20%) reside in the asymmetric allele frequency region, which spans from 0.15 to 0.47 and corresponds to an order of several hundred (213 ± 47) possible targets per HLA allele that can be considered for immunogenicity validation. Overall, these findings demonstrate the significant potential of MiHAs as targets for T-cell immunotherapy and emphasize the need for the systematic discovery of novel MiHAs.

Very Low-Level Heteroplasmy mtDNA Variations Are Inherited in Humans

Little is known about the inheritance of very low heteroplasmy mitochondria DNA (mtDNA) variations. Even with the development of new next-generation sequencing methods, the practical lower limit of measured heteroplasmy is still about 1% due to the inherent noise level of the sequencing. In this study, we sequenced the mitochondrial genome of 44 individuals using Illumina high-throughput sequencing technology and obtained high-coverage mitochondria sequencing data. Our study population contains many mother–offspring pairs. This unique study design allows us to bypass the usual heteroplasmy limitation by analyzing the correlation of mutation levels at each position in the mtDNA sequence between maternally related pairs and non-related pairs. The study showed that very low heteroplasmy variants, down to almost 0.1%, are inherited maternally and that this inheritance begins to decrease at about 0.5%, corresponding to a bottleneck of about 200 mtDNA.

Human ability to detect kinship in strangers' faces: effects of the degree of relatedness

The resemblance between human faces has been shown to be a possible cue in recognizing the relatedness between parents and children, and more recently, between siblings. However, the general inclusive fitness theory proposes that kin-selective behaviours are also relevant to more distant relatives, which requires the detection of larger kinship bonds. We conducted an experiment to explore the use of facial clues by 'strangers', i.e. evaluators from a different family, to associate humans of varying degrees of relatedness. We hypothesized that the visual capacity to detect relatedness should be weaker with lower degrees of relatedness. We showed that human adults are capable of (although not very efficient at) assessing the relatedness of unrelated individuals from photographs and that visible facial cues vary according to the degree of relatedness. This sensitivity exists even for kin pair members that are more than a generation apart and have never lived together. Collectively, our findings are in agreement with emerging knowledge on the role played by facial resemblance as a kinship cue. But we have progressed further to show how the capacity to distinguish between related and non-related pairs applies to situations relevant to indirect fitness.

Similarity of the brains of twins

To test the assumption underlying every morphometric twin study that the brains of monozygotic twins are almost identical. High resolution MRI of the neurocranium of 26 monozygotic twin pairs were acquired and the volumes of 36 cerebral structures were measured. The same twins served as control group after rear-ranging them into non-related pairs of same sex and matching them for age, body height and body weight. For most of the examined structures the correlations within the twins were significant (R = 0.97-0.59). Except for total forebrain volume the controls showed no significant similarity. For almost every measured cerebral structure the assumption, that significant similarities exist between healthy monozygotic twins is correct. Therefore discordant monozygotic twins represent an excellent sample when investigating cerebral correlates of neurologic and psychiatric disorders.

A technique for dual determination of cytotoxic and helper lymphocyte precursor frequency by a miniaturized dye release method.

Helper (HTLPf) and cytotoxic (CTLPf) lymphocyte precursor frequency assays are increasingly used in bone marrow stem cell and organ transplant compatibility testing. Current techniques require large cell numbers and radioisotopes. To improve the technique, we developed a miniaturized fluorescent read-out combined HTLPf/CTLPf limiting dilution assay. The assay requires only 5 x 10(6) stimulators, 2 x 10(6) responders and 0.24 x 10(6) target cells in Terasaki plates (40 microl/well). For the HTLPf, culture supernatants from each well were assayed for IL-2 production. The IL-2-dependent proliferation of the mouse 9.12 cell line was detected by a semi-automated fluorescent dye technique. After addition of rhIL-2 (recombinant human IL-2) on days 3 and 7, CTLPs were detected on day 10 by measuring the lysis of dye-labeled targets. Results were comparable to standard radioisotope-based techniques. The assay had a coefficient of variation of approximately 30%. The assay detected helper CD4 cells, pure cytotoxic CD8, helper CD8 cells and helper/cytotoxic CD8 cells. Discrimination was demonstrated between HLA-matched related and non-related pairs. The ease of testing and small cell numbers required should facilitate further evaluation of HTLPf and CTLPf for compatibility testing in unrelated donor transplantation and monitoring immune responses following adoptive transfer of lymphocytes.

Right Hemisphere Activation during Indirect Semantic Priming: Evidence from Event-Related Potentials

Healthy subjects performed a lexical decision task in a semantic priming paradigm while event-related potentials (ERPs) were recorded from 64 channels. Semantic distance between prime and target was varied by including directly, indirectly, and nonrelated word pairs. At centro-parietal electrodes an N400 to nonrelated pairs was elicited bilaterally which was sensitive only to direct, but not to indirect semantic priming. These N400 priming effects were mirrored by the RT data. At inferior fronto-temporal sites directly related words showed ERP priming effects over both hemispheres. However, indirectly related words only elicited ERP priming effects over the right hemisphere. These results support the hypothesis that the right hemisphere semantic system is involved in processing of remote semantic information.

Mutual Reciprocity of Grooming in Female Japanese Macaques (Macaca Fuscata)

AbstractGrooming interactions among female Japanese macaques (Macaca fuscata) were observed and compared between affiliated and unaffilitated non-related pairs, mother and adult female offspring paris, and mother and immature offspring pairs. Unaffiliated (rarely interacting) members of pairs were likely to approach and then groom the other, in contrast to affiliated (frequently interacting) pairs, who more often approached and then solicited grooming from the other. The return receipt of a benefit just given, in the form of reciprocation of grooming, was immediate in non-related pairs. The brief interval between the occurrence of reciprocation facilitated the estimation of receiving as much benefit as was given in the case of rare grooming. However, such was not the case for related pairs. Adult female offspring solicited grooming from mothers more than immature offspring. The findings are discussed with reference to previous theories about the evolution of altruistic behaviour.