Nonmetallic Nanoparticles Research Articles

A Critical Review of the Phenomenon of Inhibiting Asphaltene Precipitation in the Petroleum Industry

This comprehensive review examines chemical and nano-based methods for asphaltene inhibition in the oil industry, focusing on recent developments and challenges. Asphaltene precipitation and deposition remain significant challenges in oil production, affecting wellbore areas, equipment walls, and surface infrastructure. The review analyzes various chemical inhibition mechanisms and evaluation methods, highlighting the emergence of nanotechnology as a promising solution. Metal oxide nanoparticles, organic nanoparticles, and inorganic nonmetal nanoparticles are discussed as effective inhibitors, with particular attention to their performance in different operational conditions, including CO2 flooding processes. The study reveals that nanoparticles’ effectiveness in asphaltene inhibition is attributed to their large specific surface area, strong adsorption capacity, and unique interaction mechanisms with asphaltene molecules. The review also emphasizes the importance of proper inhibitor selection and concentration optimization, as the effectiveness thereof varies with reservoir conditions and crude oil characteristics. Recent developments in functionalized nanoparticles and their applications in enhanced oil recovery are examined, providing insights into future directions for asphaltene management in the petroleum industry.

Thermal characteristics of hybrid Nanofluid (Cu-Al2O3) flow through Darcy porous medium with chemical effects via numerical successive over relaxation technique

The flow of fluids through porous media is commonly described using the Darcy model, therefore investigating hybrid nanofluids in this setting is rather new. The present work offers insightful information on how the hybrid nanofluids behave and function in porous medium. The study's conclusions may have an impact on a lot of different engineering applications like filtration systems, chemical reactors, and environmental engineering. The study concentrates on a hybrid nanofluid which consists of Cu and Al₂O₃ nanoparticles. The metallic nanoparticles such as copper have high thermal conductivity and non-metallic nanoparticles such as aluminum oxide are chemically stable and has high thermal resistance. This is the reason that the combination Cu-Al₂O₃ is believed to give better heat transfer composite than using individual nanofluids. By employing proper similarity transformation, the governing PDEs are turned into ODEs. To discretize these ODEs, the central finite difference method is used first. Then the successive over relaxation technique is utilized to numerically solve the nonlinear equations. The findings are summarized in a graphical and tabular format. The impacts of several controlling parameters such as porosity, suction, Schmidt number and volume fraction on flow pattern, thermal properties, and concentration are investigated and discussed. The streamwise and normal velocity profiles fall and those of concentration and temperature rise with increase in the values of the porosity parameter.

Selective and complementary antimicrobial and antiviral activity of silver, copper, and selenium nanoparticle suspensions in deep eutectic solvent

Metallic and nonmetallic nanoparticles are bioactive compounds that exhibit broad resistance to bacteria, fungi, and even viruses. In this paper, a deep eutectic solvent (DES) based on betaine, glucose, and ethylene glycol was used to obtain suspensions of silver, copper, and selenium nanoparticles. Depending on the nanoparticle precursor used, Ag, Cu, and Se nanoparticles (NPs) with an average particle size of 50–100 nm were prepared, and the properties of the products were confirmed by the STEM, XPS, DLS, and UV–VIS methods. The use of a DES, without the need for additional reactants, allowed the production of stable nanoparticles with increased bioactivity against microorganisms. The obtained systems showed high bioactivity against strains of S. aureus, E. coli, and C. albicans. Nanosuspensions, by generating reactive oxygen species (ROSs), caused enzyme inactivation and the inhibition of the metabolic processes of microorganisms. Particle-generated cell degradation processes were investigated through ROS generation assays, API assays, the determination of the MIC/MBC, and cell decomposition rate assays in the early logarithmic growth phase. Copper nanoparticles derived from copper(II) acetate were also highly active against the human influenza A/H1N1 viruses, human coronavirus (HCoV-OC43, Betacoronavirus 1), and vesicular stomatitis virus (VSV, Rhabdoviridae), showing a virus titer reduction of more than 93.7−99.96%.

Microfluidic Synthesis of Magnetic Nanoparticles for Biomedical Applications.

Magnetic nanoparticles have attracted great attention and become promising candidates in the biomedicine field due to their special physicochemical properties. They are generally divided into metallic and non-metallic magnetic nanoparticles, according to their compositions. Both of the two types have shown practical values in biomedicine applications, such as drug delivery, biosensing, bioimaging, and so on. Research efforts are devoted to the improvement of synthesis strategies to achieve magnetic nanoparticles with controllable morphology, diverse composition, active surface, or multiple functions. Taking high repeatability, programmable operation, precise fluid control, and simple device into account, the microfluidics system can expand the production scale and develop magnetic nanoparticles with desired features. This review will first describe different classifications of promising magnetic nanoparticles, followed by the advancements in microfluidic synthesis and the latest biomedical applications of these magnetic nanoparticles. In addition, the challenges and prospects of magnetic nanoparticles in the biomedical field are also discussed.

Combatting Helicobacter pylori: A Focus on Nanomaterials.

Developing effective non-antibiotic antimicrobial strategies is essential for combating global antibiotic resistance, including resistance stemming from Helicobacter pylori (H. pylori) treatment. Nanomaterials offer a promising and innovative approach for non-antibiotic anti-H. pylori treatment strategies. This review highlights the progress made in the use of metallic and nonmetallic nanoparticles, as well as nanozymes, to directly inhibit H. pylori growth. Moreover, we summarize advances made in the direct targeting of H. pylori by nanomaterials and the stimuli-responsive release of nanoparticles in the stomach. Additionally, we explore the recent advancements in multifunctional nanoplatforms that integrate physical methods, such as light, heat, ultrasound, and magnetism, with nanomaterials to synergistically treat H. pylori infections. Finally, we briefly address the existing challenges and future directions in this field. In summary, we highlight that with ongoing research, nanomaterials may serve as a promising treatment strategy for H. pylori eradication.

Electrochemical recovery of ruthenium via carbon black nano-impacts

The recovery of ruthenium from low-concentration solutions poses a significant challenge due to its scarcity and rising economic value, and nano-impact electrochemistry has emerged as a promising method for efficient recovery of critical metals from solution through deposition during impacts of non-metallic nanoparticles. In this study, we investigate the redox chemistry of ruthenium on carbon black via the impact technique and demonstrate the ability to recover ruthenium from solution. The reduction (electrodeposition) and oxidation of Ru3+ ions in solution onto carbon black nanoparticles can be observed during nano-impacts with the respective onset potentials of these redox processes agreeing with those obtained from solution voltammetry. Upscaled experiments focusing on the electroreduction process, led to the formation of RuOx deposits, confirmed through scanning electron microscopy/energy-dispersive X-ray (SEM/EDX) analysis, X-ray photoelectron spectroscopy (XPS) analysis, and thermogravimetric analysis (TGA). Under partially-optimised conditions, >90 % recovery of Ru(III) from a 1 mM solution was achieved in ca. 8 h.

Synergistic antibacterial effects of selenium-doped gold nanosheets with notable near infrared-II photothermal conversion against multidrug-resistant bacteria

Non-metallic nanoparticles are increasingly acknowledged for their broad-spectrum antibacterial properties, which often face limitations due to structural instability and potential biotoxicity. To address these challenges, integrating non-metallic nanoparticles with plasmonic metal nanostructures offers a promising solution. This fusion not only enhances structural stability but also reduces the required dosage. The synergistic coupling of the inherent antibacterial properties of non-metallic nanoparticles with the plasmonic absorption and photothermal conversion capabilities of metal nanostructures significantly amplifies antibacterial efficacy. In this study, we validate this concept by presenting the successful synthesis of selenium-doped gold nanosheets (AuSe NSs) that demonstrate robust absorption in the second near-infrared (NIR-II) window and exhibit efficient photothermal conversion, followed by testing their antibacterial activity. Notably, Au NSs were synthesized with high shape purity, followed by the introduction of SeO2 and ascorbic acid to facilitate Se doping. The resulting products displayed a uniform distribution of both Au and Se elements, while maintaining the NIR-II absorbance characteristic of Au nanosheets unaffected by the Se doping as evidenced by both experimental and FDTD simulation results. Subsequent assessments of the AuSe NSs demonstrated their potent synergistic antibacterial effects against multidrug-resistant bacteria at minimal inhibitory concentrations (MICs), which suggests that lower dosages can be employed and benefit minimizing potential side effects and optimizing treatment efficiency. Our findings indicate a synergistic boost between the photothermal attributes originating from Au's NIR absorption and Se's inherent antibacterial properties—an aspect minimally explored in prior research and offering a novel solution to tackling antibiotic-resistant bacterial strains.

Universal Click-Chemistry Approach for the DNA Functionalization of Nanoparticles.

Nanotechnology has revolutionized the fabrication of hybrid species with tailored functionalities. A milestone in this field is the deoxyribonucleic acid (DNA) conjugation of nanoparticles, introduced almost 30 years ago, which typically exploits the affinity between thiol groups and metallic surfaces. Over the last decades, developments in colloidal research have enabled the synthesis of an assortment of nonmetallic structures, such as high-index dielectric nanoparticles, with unique properties not previously accessible with traditional metallic nanoparticles. However, to stabilize, integrate, and provide further functionality to nonmetallic nanoparticles, reliable techniques for their functionalization with DNA will be crucial. Here, we combine well-established dibenzylcyclooctyne-azide click-chemistry with a simple freeze-thaw method to achieve the functionalization of silica and silicon nanoparticles, which form exceptionally stable colloids with a high DNA surface density of ∼0.2 molecules/nm2. Furthermore, we demonstrate that these functionalized colloids can be self-assembled into high-index dielectric dimers with a yield of over 50% via the use of DNA origami. Finally, we extend this method to functionalize other important nanomaterials, including oxides, polymers, core-shell, and metal nanostructures. Our results indicate that the method presented herein serves as a crucial complement to conventional thiol functionalization chemistry and thus greatly expands the toolbox of DNA-functionalized nanoparticles currently available.

Bioactive nanoparticles derived from marine brown seaweeds and their biological applications: a review.

The biosynthesis of novel nanoparticles with varied morphologies, which has good implications for their biological capabilities, has attracted increasing attention in the field of nanotechnology. Bioactive compounds present in the extract of fungi, bacteria, plants and algae are responsible for nanoparticle synthesis. In comparison to other biological resources, brown seaweeds can also be useful to convert metal ions to metal nanoparticles because of the presence of richer bioactive chemicals. Carbohydrates, proteins, polysaccharides, vitamins, enzymes, pigments, and secondary metabolites in brown seaweeds act as natural reducing, capping, and stabilizing agents in the nanoparticle's synthesis. There are around 2000 species of seaweed that dominate marine resources, but only a few have been reported for nanoparticle synthesis. The presence of bioactive chemicals in the biosynthesized metal nanoparticles confers biological activity. The biosynthesized metal and non-metal nanoparticles from brown seaweeds possess different biological activities because of their different physiochemical properties. Compared with terrestrial resources, marine resources are not much explored for nanoparticle synthesis. To confirm their morphology, characterization methods are used, such as absorption spectrophotometer, X-ray diffraction, Fourier transforms infrared spectroscopy, scanning electron microscope, and transmission electron microscopy. This review attempts to include the vital role of brown seaweed in the synthesis of metal and non-metal nanoparticles, as well as the method of synthesis and biological applications such as anticancer, antibacterial, antioxidant, anti-diabetic, and other functions.

Nanoparticles for the treatment of spinal cord injury.

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

Experimental studies on the effect of Al2O3 + water nanofluid concentrations on dimensionless heat transfer parameters in a cleanroom air handling unit

Nanofluid, a colloidal suspension of nonmetallic or metallic nanoparticles into conventional base fluid and used for heat transfer characteristics enhancement for many industrial applications. Cleanrooms are essential at various industries for controlling airborne contamination and environmental parameters. In this article, heat transfer properties of nanofluid (Al2O3 + water) at various nanoparticle concentrations (1%, 2%, and 3%) on a prototype cleanroom air handling chiller unit was investigated experimentally in laminar flow zone. Thermal conductivity ratio, Nusselt number, Peclet number, and pressure drop were obtained for above nanoparticle concentrations. Experimental investigations indicate the heat transfer properties improvement in a prototype cleanroom air handling chiller unit by using nanoparticle at base fluid. Experimental investigation on varying Al2O3 + water nanofluid concentrations in a cleanroom air handling chiller unit heat exchanger revealed a notable increase in heat transfer by reducing nanoparticle size from 50 to 10 nm and increasing concentration from 1% to 3% volume, resulting in a 17.70% rise in thermal conductivity ratio and a significant 9.23% increase in Nusselt number at higher Peclet numbers. However, this improvement in heat transfer was accompanied by a substantial 72.5% increase in pressure drops, particularly with increased Reynolds number and particle concentration. Manipulating nanoparticle characteristics resulted in substantial improvements in Nusselt number across a wide range of Reynolds numbers, with smaller particle sizes and higher volume concentrations yielding more significant heat transfer improvements. The novelty of this research lies in its investigation of the influence of variable Al2O3 + water nanofluid concentrations, encompassing different nanoparticle sizes, and volume concentrations, on dimensionless heat transfer parameters within a cleanroom air handling unit, offering valuable insights into optimizing heat transfer efficiency in a controlled and critical environment, addressing a significant research gap in the field.

Research Progress in Nanoparticle Inhibitors for Crude Oil Asphaltene Deposition.

Currently, the alteration of external factors during crude oil extraction easily disrupts the thermodynamic equilibrium of asphaltene, resulting in the continuous flocculation and deposition of asphaltene molecules in crude oil. This accumulation within the pores of reservoir rocks obstructs the pore throat, hindering the efficient extraction of oil and gas, and consequently, affecting the recovery of oil and gas resources. Therefore, it is crucial to investigate the principles of asphaltene deposition inhibition and the synthesis of asphaltene inhibitors. In recent years, the development of nanotechnology has garnered significant attention due to its unique surface and volume effects. Nanoparticles possess a large specific surface area, high adsorption capacity, and excellent suspension and catalytic abilities, exhibiting unparalleled advantages compared with traditional organic asphaltene inhibitors, such as sodium dodecyl benzene sulfonate and salicylic acid. At present, there are three primary types of nanoparticle inhibitors: metal oxide nanoparticles, organic nanoparticles, and inorganic nonmetal nanoparticles. This paper reviews the recent advancements and application challenges of nanoparticle asphaltene deposition inhibition technology based on the mechanism of asphaltene deposition and nano-inhibitors. The aim was to provide insights for ongoing research in this field and to identify potential future research directions.

Effect of metallic and nonmetallic nanoparticles (NPs) and their salts in reproductive biotechnology

Effect of metallic and nonmetallic nanoparticles (NPs) and their salts in reproductive biotechnology

Adverse Effects of Non-Metallic Nanoparticles in the Central Nervous System

The interest in nanoparticles (NPs) and their effects on living organisms has been continuously growing in the last decades. A special interest is focused on the effects of NPs on the central nervous system (CNS), which seems to be the most vulnerable to their adverse effects. Non-metallic NPs seem to be less toxic than metallic ones; thus, the application of non-metallic NPs in medicine and industry is growing very fast. Hence, a closer look at the impact of non-metallic NPs on neural tissue is necessary, especially in the context of the increasing prevalence of neurodegenerative diseases. In this review, we summarize the current knowledge of the in vitro and in vivo neurotoxicity of non-metallic NPs, as well as the mechanisms associated with negative or positive effects of non-metallic NPs on the CNS.

CT and X-ray contrast agents: Current clinical challenges and the future of contrast.

Computed tomography (CT) is a powerful and widely used imaging technique in modern medicine. However, it often requires the use of contrast agents to visualize structures with similar radiographic density. Unfortunately, current clinical contrast agents (CAs) for CT have remained largely unchanged for decades and come with several significant drawbacks, including serious nephrotoxicity and short circulation half-lives. The next generation of CT radiocontrast agents should strive to be long-circulating, non-toxic, and non-immunogenic. Nanoparticle contrast agents have shown promise in recent years and are likely to comprise the majority of next-generation CT contrast agents. This review highlights the fundamental mechanism and background of X-ray and contrast agents. It also focuses on the challenges associated with current clinical contrast agents and provides a brief overview of potential future agents that are based on various materials such as lipids, polymers, dendrimers, metallic, and non-metallic inorganic nanoparticles (NPs). STATEMENT OF SIGNIFICANCE: We realized a need for clarification on a number of concerns related to the use of iodinated contrast material as debates regarding the safety of these agents with patients with kidney disease, shellfish allergies, and thyroid dysfunction remain ongoing in medical practice. This review was partially inspired by debates witnessed in medical practice regarding outdated misconceptions of contrast material that warrant clarification in translational and clinical arenas. Given that conversation around currently available agents is at somewhat of a high water mark, and nanoparticle research has now reached an unprecedented number of readers, we find that this review is timely and unique in the context of recent discussions in the field.

The effect of number of nanoparticles on atomic behavior and aggregation of CuO/water nanofluid flow in microchannels using molecular dynamics simulation

A nanofluid (NF) is a mixture of metallic or non-metallic nanoparticles (NPs) suspended in a fluid. The high activity and energy of the surface atoms of NPs cause them to stick together and aggregate in the base fluid (BF). This leads to instability, changes in the NF concentration, and fouling and obstruction of the flow path, which reduces the NF's thermal conductivity (TC). In this study, the effect of copper oxide NPs on atomic behavior and the aggregation procedure in a water/CuO NF flow in a microchannel was explained using a Molecular Dynamics (MD) simulation procedure. For this purpose, various physical parameters, such as density, temperature, velocity, aggregation time (AT), and potential energy (PE), were calculated. The resultsshowthat after 1 ns, the temperature and PE converged to 300 K and −553088 eV. By CuO NPs number increasing among H2O molecules, the maximum ratio of density, temperature, and V profiles reached 1.60 g/cm3, 0.0122 Å/ps, and 303 values. The aggregation process in simulated NF was varied by these atomic changes. From a numerical point of view, by CuO NPs number increasing from 2 to 3 NPs, the AT reduced by 1.15 ns to 1.01 ns. Furthermore, this atomic evolution was investigated by PE changed from −652411 to −660258 eV.

Enhancing heat transfer performance of automotive car radiator using camphor nanoparticles: experimental study with bibliometric analysis

In this study, an attempt was made to investigate the heat transfer performance of a four-wheeler automotive radiator using a novel coolant system. To support this study, we also added bibliometric analysis to show the importance of this study. In the experiments, camphor nanoparticles (sizes of 511 nm) with various loadings (i.e. 2, 4, 6, and 8%) were mixed with deionized water (DW) to create a coolant. The experiments were conducted at different heat convection processes (i.e. 0.5, 1.45, and 3.7 m/s). The significant heat transfer performance parameters, such as Reynolds number (Re), Nusselt number (Nu), overall heat transfer coefficient (U), and heat transfer rate (Q), were examined. The Fourier Transform Infrared results revealed the presence of significant functional groups in the coolant system. camphor nanoparticles dispersed in DW were stable for more than 8 hours. At 70 ᵒC, the novel coolant (2% camphor nanoparticles in DW) exhibits better Re, Nu, U, and Q than that using pure DW or other loadings of nanoparticles (e.g. 4, 6, and 8%). The high percentage of camphor nanoparticles in DW restricts the fluid flow, resulting in a drop in overall heat transfer performance. Finally, low-cost, easily available, and eco-friendly camphor nanoparticles (2%) are suggested as a better choice in lieu of high-cost metallic and non-metallic nanoparticles as an additive in the coolant system.

Overview of Various Components of Lateral-Flow Immunochromatography Assay for the Monitoring of Aflatoxin and Limit of Detection in Food Products: A Systematic Review

The detection of aflatoxins is essential for the food industry to ensure the safety and quality of food products before their release to the market. The lateral-flow immunochromatography assay (LFIA) is a simple technique that allows the rapid on-site detection of aflatoxins. The purpose of this review is to evaluate and compare the limits of detection reported in the most recent research articles, published between the years of 2015 and 2023. The limits of detection (LODs) were compared against the particle type and particle size, as well as other variables, to identify trends and correlations among the parameters. A growing interest in the use of different metal and non-metal nanoparticles was observed over the years of 2015–2023. The diameters of the nanoparticles used were reportedly between 1 nm and 100 nm. Most of these particles displayed lower LODs in the range of 0.01 to 1.0 ng/mL. Furthermore, there was a significant level of interest in detecting aflatoxin B1, perhaps due to its high level of toxicity and common appearance in food products. This study also compares the use of metallic and non-metallic nanoparticles in detecting aflatoxins and the dependence of nanoparticles’ sizes on the detection range. Overall, the type of particle and particle size used in the development of LFIA strips can affect the sensitivity and LOD; hence, the optimization of these parameters and their modulation with respect to certain requirements can enhance the overall assay performance in terms of the reproducibility of results and commercialization.

Investigation of H2 enrichment of ternary blended fuel modified with graphene nanoplate on cycle-by-cycle variations

Despite the global goal of achieving e-mobility in the future, the majority of the transportation sector still heavily relies on fossil fuels. Previous studies in the area have revealed the benefits of hydrogen additives and nanoparticles mixed with blended diesel fuels on engine performance and emissions. However, there is a significant gap in the research when it comes to exploring the combination of non-metallic nanoparticle additives with alcohol and diesel blend fuels under dual-fuel mode with hydrogen. In the study, a fuel blend (BF) comprising 80% diesel, 10% n-butanol, and 10% ethanol, which represents a potential alternative fuel composition for compression ignition engines, was specifically focused on. To further enhance the fuel properties and combustion characteristics, the addition of 50 ppm graphene nanoplatelets (GNP) was introduced as a non-metallic additive. By examining this novel fuel composition and investigating its impact under both single and dual-fuel mode, the dimension of hydrogen addition in the dual-fuel mode is aimed to explore potential synergistic effects. A diesel engine was used under dual fuel mode, with hydrogen fed at a rate of 0.25 g/min. The prepared fuels were tested at 1800 rpm engine speed by applying five different loads. 50 ppm GNP of modified fuels resulted in an increase of peak pressures by 3.1%, 4.2%, and 5.6% for DGNP, BFGNP, and BFGNP15H respectively, compared to D. At full load, the COVIMEP values were approximately 0.3%, 0.2%, 0.4%, 1.3%, and 1.6% for D, DGNP, BF, BFGNP, and BFGNP15H, respectively. In the term of thermal efficiency, BFGNP15H had a 3.9% lower BTE than BFGNP at 25% load, but BFGNP15H showed a 0.4% increase in BTE at full load compared to BFGNP. For emission analysis, BFGNP15H showed a reduction of 42.31%, 15.1%, and 10% in CO emissions compared to D, BF, and BFGNP, respectively, under full load in dual operating condition. However, the NO emissions of BFGNP15H were 7.2% higher than those of D under the same condition.

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics.

From a clinical perspective, local anesthetics have rather widespread application in regional blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer treatments. However, a number of disadvantages are associated with traditional local anesthetic agents as well as routine drug delivery administration ways, such as neurotoxicity, short half-time, and non-sustained release, thereby limiting their application in clinical practice. Successful characterization of drug delivery systems (DDSs) for individual local anesthetic agents can support to achieve more efficient drug release and prolonged duration of action with reduced systemic toxicity. Different types of DDSs involving various carriers have been examined, including micromaterials, nanomaterials, and cyclodextrin. Among them, nanotechnology-based delivery approaches have significantly developed in the last decade due to the low systemic toxicity and the greater efficacy of non-conventional local anesthetics. Multiple nanosized materials, including polymeric, lipid (solid lipid nanoparticles, nanostructured lipid carriers, and nanoemulsions), metallic, inorganic non-metallic, and hybrid nanoparticles, offer a safe, localized, and long-acting solution for pain management and tumor therapy. This review provides a brief synopsis of different nano-based DDSs for local anesthetics with variable sizes and structural morphology, such as nanocapsules and nanospheres. Recent original research utilizing nanotechnology-based delivery systems is particularly discussed, and the progress and strengths of these DDSs are highlighted. A specific focus of this review is the comparison of various nano-based DDSs for local anesthetics, which can offer additional indications for their further improvement. All in all, nano-based DDSs with unique advantages provide a novel direction for the development of safer and more effective local anesthetic formulations.