Therapy For Nonmelanoma Skin Cancer Research Articles

Photodynamic therapy for non-melanoma skin cancer

Photodynamic therapy is a treatment modality that has been shown to be effective mainly for the dermato-oncologic conditions: actinic keratosis, Bowen's disease, in situ squamous cell carcinoma and basal cell carcinoma. Recent work has focused on the development and evaluation of topical photosensitizers like the haem precursor 5-aminolevulinic acid or its methyl ester, both inducing photosensitizing porphyrins. These drugs do not induce strong generalized cutaneous photosensitization, unlike the systemically applied porphyrins or their derivatives. For dermatological purposes incoherent lamps or light-emitting diode arrays can be used for light activation. Cure rates reported for very superficial lesions (tumour thickness <2-3 mm) are comparable to those achieved by other therapeutic modalities. Photodynamic therapy is a minimally invasive therapy associated with excellent cosmetic results. For actinic keratosis and basal cell carcinoma, methyl aminolevulinate-photodynamic therapy is already approved in Europe, Australia and New Zealand, and is now also approved for actinic keratosis in the US.

What is the Microscopic Tumor Extent beyond Clinically Delineated Gross Tumor Boundary in Nonmelanoma Skin Cancers?

Purpose/Objective: To quantify the microscopic tumor extension beyond clinically delineated gross tumor boundary in nonmelanoma skin cancers. Little information exists in literature for this subject. When radiotherapy (RT) is applied as a primary, definitive therapy for nonmelanoma skin cancers, the accurate assessment of microscopic tumor extent is a critical element for the success of RT. Tissue volume containing the sub-clinical microscopic tumor extent is equivalent to clinical target volume in radiotherapy setting.

Photodynamic therapy for nonmelanoma skin cancers: Current review and update

Photodynamic therapy (PDT) is a therapeutic modality involving the use of a photosensitizing agent activated by light to destroy tumor cells. Over the past 25 years, PDT has been shown useful in the treatment of actinic keratoses and certain nonmelanoma skin cancers, such as Bowen’s disease and basal cell carcinoma. We review the current data available for PDT with systemic photofrin and topical 5-aminolevulinic acid (ALA). PDT offers many advantages including its non-invasiveness and its ability to treat multiple lesions simultaneously and is, therefore, an interesting alternative for treating certain skin malignancies.

Radiation therapy for nonmelanoma skin cancers.

Radiation therapy for nonmelanoma skin cancers.

Photodynamic therapy for non-melanoma skin cancer

Photodynamic therapy for non-melanoma skin cancer

Photodynamic therapy of nonmelanoma skin cancer with topical aminolevulinic acid: a clinical and histologic study

In dermatology, photodynamic therapy (PDT) has been used primarily for treating malignant skin tumors and involves the sequential administration of photosensitizing drugs and light to patients. Aminolevulinic acid is a naturally occurring porphyrin precursor that can photosensitize cutaneous neoplasms for destruction by light when applied topically in pharmacologic doses. Exogenous topical aminolevulinic acid appears to be taken up preferentially by tumors and metabolized in situ to protoporphyrin IX, a photosensitive compound. 1,2 Kennedy et al 1,2 reported first on the use of topical aminolevulinic acid and red light to photosensitize skin tumors in patients. There has been limited longterm clinical follow-up data concerning patients treated with aminolevulinic acid and light, and there is also a lack of detailed histologic studies assessing microscopic tumor responses to therapy. Subjects and Methods. Five patients with one or more biopsy-proven and previously untreated basal cell or squamous cell (in situ or invasive) carcinomas measuring

Advances in the Treatment of Nonmelanoma Skin Cancer

Nonsurgical and nonradiation therapy for nonmelanoma skin cancer is focusing on immunotherapy, recombinant human gene products, localized delivery of radiant energy, photodynamic therapy, and retinoids. Although they are not currently practical for widespread application to nonmelanoma skin cancer, there is good reason to hope for significant therapeutic advances in these areas, which will make successful nonsurgical therapy widely available.

Photodynamic Therapy for Nonmelanoma Skin Cancer

Photodynamic Therapy for Nonmelanoma Skin Cancer