Background: - In Ethiopian medical care system, medical record unit is an entry to medical care services which is 100% run by non-medical health care workers. Therefore, looking at their knowledge and attitude towards ICT as a pre-requisite to electronic medical record system is mandatory. Methods: Institutional based cross-sectional study design was conducted from November 15, 2017 to 30, and 2017 G. C. Descriptive statistics like frequency tables and percentages were used to present descriptive data. At bivariable analysis, the effect of each independent variable was tested at individual level holding other variables constant against the dependent variable. Finally, variables with p-value<0.2 were taken to multivariate analysis and existence of association was declared for variables with p-value<0.05 at 95% confidence interval. Result: A total of 261 study participants were involved in the study with a response rate of 91.3%. The mean age of the participants was 26 (SD=±6.8) and 111 (42.5%) of their age group was ≤25 years of old. Of all the study participants, 169 (64.8%) of them had adequate knowledge. However, only 141 (54%) of the study participants had favorable attitude towards ICT. At multivariate analysis only residence (AOR=2.56, 95% CI [1.28, 5.10]), workload (AOR=3.67, 95% CI [1.92, 7.00]) and basic computer training (AOR=14.5, 95% CI [6.82, 30.9]) were identified as factors affecting knowledge towards ICT while residence (AOR=7.04, 95% CI [3.5, 14.17]), experience (AOR=1.99, 95% CI [1.06, 3.72]), workload (AOR=2.84, 95% CI [1.5, 5.38]) and availability of a computer (AOR=9.16, 95% CI [4.17, 20.11]) were factors affecting attitude towards ICT. Conclusion and recommendations: The level of knowledge and attitude towards ICT among non-health care provider medical unit workers was very low as per expectations and compared to literatures reviewed in this research. Recruiting additional medical record unit workers, giving training, availing computer, creating a mechanism experience sharing and on job training were recommended to improve the problem.