We study the Cauchy problem for the doubly nonlocal equation where and for some m ∈ ℝ and 0 < α ≤ +∞, here α = +∞ means that J is compactly supported. The problem not only describes nonlocal diffusions and nonlocal interactions, but also it is a nonlocal counterpart of the nonlocal heat equation in [10] where and m > 0. As for the local existence of positive solutions, we find that problem (0.1) is quite different from the nonlocal heat equation. That is, problem (0.1) admits positive solutions if and only if m > n − q(n + α), however the nonlocal heat equation has positive solutions for any m ∈ ℝ. For m ≥ 0 or n(1 − q) < m < 0 with α = +∞, we determine the critical Fujita curve of problem (0.1) as F(p, q, n, m, r, α) := (p − 1)[nq − (n − m)+] − q(β − nr) = 0 with β = min{α, 2}. That is, if F ≤ 0, every positive solution of (0.1) blows up in finite time, whereas if F > 0, there exist both nonglobal solutions and global solutions. In the supercritical case F > 0, we further discuss the second critical exponent which describes the critical decay rate of initial data to distinguish both solutions. Particularly, we find a new phenomenon, namely, if with α = +∞, the second critical exponent is independent of p and r.