AbstractWe study a class of second-order nonlinear differential equations on a finite interval with periodic boundary conditions. The nonlinearity in the equations can take negative values and may be unbounded from below. Criteria are established for the existence of non-trivial solutions, positive solutions and negative solutions of the problems under consideration. Applications of our results to related eigenvalue problems are also discussed. Examples are included to illustrate some of the results. Our analysis relies mainly on topological degree theory.