In this paper asymmetry in sagging and hogging of a hull progressing in regular waves is investigated by applying a weakly nonlinear potential flow theory. At first instance ship motions in waves are evaluated using a linear strip-theory yielding transfer functions of ship motions and sectional loads. Then, by assuming time-histories of ship motions the nonlinear part of the Froude-Krylov and restoring forces and moments are evaluated using a panel representation. Linear and weakly nonlinear predictions are compared against available model tests for a roll-on/off (Ro-Pax) ship hull. The results confirm that importance of nonlinearities of restoring and Froude-Krylov part of wave loading on asymmetry of sagging and hogging.