This contribution develops the model predictive control for an unstable chemostat reactor. Initially, we analyze the system’s model — a nonlinear first-order hyperbolic partial integro-differential equation (PIDE) — and carry the model linearization around an unstable operating condition. Employing the structure-preserving Cayley–Tustin transformation, we obtain a discrete-time model representation of the continuous model. Subsequently, we solve the operator Ricatti equations in the discrete-time setting to derive a full state feedback controller that stabilizes the closed-loop and design a Luenberger observer for state reconstruction given the system output measures. Finally, we formulate a dual-mode MPC ensuring constraint satisfaction and optimality, integrating the gain-based unconstrained full-state feedback optimal control obtained from the Ricatti equation. This dual-mode strategy describes an optimization problem where the predictive controller acts only if constraints become active within the control horizon. Simulation studies validate the controller performance, where the MPC only takes action if the constraints are predicted to be active within the control horizon while also guaranteeing closed-loop stabilization under only output feedback. This type of controller can be easily implemented with other control strategies and significantly decreases the computational costs of solving the optimal control problems when compared to other MPC approaches.