Intermediate diaphragms are used in box girders not only to prevent premature distortion under eccentric loading conditions but also to improve the distribution of live loads. This paper reports an investigation into the effect of intermediate diaphragms on the load - carrying capacity of a Steel – Concrete Composite Box (SCCB) girder bridge with open steel box section. In the current study, a three - dimensional finite element (FE) model of the SCCB girder is developed and analyzed using ABAQUS software. The nonlinear inelastic analysis is invoked in order to accurately capture the actual behavior of the girder. The numerical model is verified with experimental results to ensure the accuracy of the FE modeling method. A parametric analysis is implemented to study the effect of intermediate diaphragms on the load – carrying capacity of an SCCB girder with a 30–60m span length. Based on parametric studies, the number of intermediate diaphragms (N) is recommended for practical design of the girder, which satisfies the requirement stated in the provisions of the AASHTO LRFD standard.