In this article, a model-free compensation learning control scheme is presented for asymmetric hysteretic systems to achieve high-precision output tracking, where the effects of asymmetric input hysteresis nonlinearities are denoted by the asymmetric Prandtl–Ishlinskii model (APIM). In the presented control scheme, the feedforward iterative learning technique is generalized to the control design of asymmetric hysteretic systems. To improve the robustness and dynamic performance of the existing feedforward learning control for hysteretic systems, both the feedback action and the differential term are utilized to design a discrete-time PD-P open-closed-loop learning control law for simultaneously compensating the asymmetric input hysteresis nonlinearities and the linear dynamics effects without constructing compensators based on their models. The initial state error of such a system is also considered, a modified initial state learning strategy is proposed to ensure the initial state error tends to a prescribed level with the increasing of iterations. By fully analyzing the properties of the APIM, the convergence conditions with respect to the input error, the state error, and the tracking error along the iteration domain are given. The simulation and experimental results are provided to demonstrate strong robustness and excellent tracking accuracy with the proposed model-free compensation learning control scheme.