ABSTRACT Background This study aims to evaluate the ocular surface health with oculus keratograph 5M (Oculus, Wetzlar, Germany) in patients, 4–6 weeks after the SB surgery. Research design and methods Adult patients with RRD who underwent SB surgery were enrolled. Subjects with the existence of any concomitant ophthalmologic diseases or topical medications that can affect the ocular surface were excluded. The ophthalmic examination and corneal imaging with oculus keratograph 5M were conducted 4–6 weeks after the surgery, following discontinuation of all topical medications. The ocular surface parameters were compared between the surgical and other eyes. Results The results showed a statistically significant difference in the ocular surface profile, including the tear meniscus height (TMH), Non-invasive keratograph breakup time (NIKBUT), Meibography, and Redness scores, between the surgical eye and the other eye four to six weeks after the procedure. Conclusion In this study, we showed convincing evidence of the role of keratography imaging in the objective evaluation of the ocular surface 4–6 weeks after SB surgery. We depicted that SB surgery disturbs the ocular surface homeostasis significantly, which can cause ocular discomfort as well as decrease visual function in patients in the post-up periods.