Non-fasting Triglyceride Research Articles

LATE HYPERTRIGLYCERIDEMIA IN VERY-LON-BIRTH-WEIGHT INFANTS FED EXCLUSIVELY HUMAN MILK

In a study to evaluate mothers' own milk for pre mature infants, we followed nonfasting serum triglyceride and cholesterol in 13 infants (gest age=29÷1 [S.D.] wks, birth wt 1205÷209 g) exclusively fed own mother's milk for > 18 wks. Triglycerides during hospitalization were 166-121, 153÷67. and 154÷96 mg/dl at 31, 33, and 35 wks post conceptional age respectively. Mean cholesterol in the nursery was 138÷31 mg/dl, and mean fat intake was 5.3÷1.6 g/kg/day which did not correlate with triglyceride or cholesterol. After discharge (mean stay 60÷18 days) triglyceride rose to 371÷324 mg/dl by 47÷6 wks post conceptional age (p<0.01 compared to 35 wks) and cholesterol decreased to 116÷37 mg/dl. Serum triglycerides measured in 25 exclusively breast-fed full term infants at 47 weeks post-conceptional age were 185.4÷81.3 mg/dl, significantly lower (p<.02) than the preterm infants at this time. At 47 wks post conceptional age, 3 of the preterm infants had severe hypertriglyceridemia--730, 810. & 1100 mg/dl. Lipid profiles showed Type I hyperlipidemia (hyperchylomicronemia), with normal levels of apoprotein CII. In 2 infants studied, post heparin extrahepatic lipoprotein lipase was absent, while hepatic lipase was in the high normal range. One year follow-up revealed normal triglycerides w/o hyperchylomicronemia. In conclusion, we report severe hypertriglyceridemia may occur post hospitalization in preterm infants fed mother's milk. This may represent a transient deficiency of extrahepatic lipoprotein lipase.

Risk factors and raised atherosclerotic lesions in coronary and cerebral arteries. Statistical analysis from the Oslo study.

In 1972-1973, about 16,200 men living in Oslo, aged 40 to 49 years, were examined for cardiovascular disease, and had a number of coronary risk factors measured. This report gives the results of 129 autopsied cases with regard to the association between raised atherosclerotic lesions in coronary and cerebral arteries and various coronary risk factors. For coronary raised lesions, the high density lipoprotein (HDL) cholesterol ratio was the most significant risk factor. Systolic blood pressure and total serum cholesterol were also significantly associated. Physical activity at work and at leisure, nonfasting triglycerides, and cigarette smoking did not show a significant association with coronary artery raised lesions. The association between total serum cholesterol and systolic blood indicates that total serum cholesterol may be more important than systolic pressure in the synergism affecting the development of coronary atherosclerosis. For cerebral artery raised lesions, blood pressure was the most important risk factor, even though serum cholesterol was highly associated with the lesions. The interaction analysis also suggested that blood pressure was more important than serum cholesterol in the synergism.

Charcoal sorbent-induced hypolipidemia in uremia and diabetes

Rats with hyperlipidemia associated with streptozotocin-induced diabetes or azotemia after subtotal nephrectomy were administered a diet containing 5% activated charcoal. Significant lowering of nonfasting serum cholesterol and triglyceride levels resulted. Charcoal-feeding also altered the abnormal high density lipoprotein electrophoresis pattern of diabetic rats toward normal.

Some Factors Related to Coronary Heart Disease Incidence in Honolulu Japanese Men: The Honolulu Heart Study

Eight thousand and six Japanese men born in the years 1900-1919 participated in the baseline examination of the Honolulu Heart Study. Of the survivors, 94.6 per cent participated in a second examination two years later. All but 23 of the second exam refusers were contacted about their health. These procedures identified 101 men who had developed coronary heart disease (CHD) for the first time during this two-year interval. This incidence was associated with elevated levels of serum cholesterol, blood pressure, relative weight, uric acid, and cigarette smoking. Considered by itself, non-fasting serum triglyceride was related to CHD incidence, but in the context of other (non-lipid) characteristics this apparent association was not significant. Cigarette smoking was related to CHD other than angina pectoris (AP) but not to AP alone, while the reverse was true for glucose intolerance. In this cohort, the association between relative weight and CHD was as strong as that between serum cholesterol and CHD.

Plasma Fatty Acids in Normolipemic and Hyperlipemic Subjects during Fasting and after Linoleate Feeding

Two normolipemic subjects, one mildly hyperlipemic subject, and two severely hyperlipemic subjects were fed diets of ordinary foods containing either 4 or 18% of calories as linoleic acid. During ingestion of the diet containing 4% of calories from linoleate, the content of palmitic acid was high and the content of oleic and linoleic acids lower in the plasma triglycerides of the hyperlipemic subjects as compared to the normolipemic individuals. The ingestion of a diet containing 18% of calories from linoleate resulted in a fall in the concentration of all lipid classes in both normal and hyperlipemic subjects. An increase was noted in the percent of linoleic acid in all lipid fractions and a decrease was observed in the percent of arachidonic acid in the cholesterol ester and phospholipid fractions in both normal and hyperlipemic persons. The percentage of arachidonic acid was lower in the plasma cholesterol esters and phospholipids of the hyperlipemic individuals while consuming both diets. In both the hyperlipemic and normolipemic individuals there were significant differences between the fasting and non-fasting nonchylomicron triglyceride fatty acid composition, the changes reflecting a shift toward the composition of the fat ingested. There were no significant differences, however, in the fatty acid composition of the cholesterol ester and phospholipid in fasted and nonfasted subjects. These results suggest that data reflecting the fasting fatty acid composition of the plasma cholesterol ester and phospholipid fractions can be obtained from nonfasting blood samples if chylomicrons are removed.