Background Altruistic live liver donation has not been reported in Europe. Our living donor liver transplant (LDLT) program began in 2007 and since then we have received 85 enquiries from potential altruistic donors, all of them for non-directed altruistic donation (NDAD). Materials and Methods: We present our Results for NDAD, with a focus on the assessment process, which includes added restrictions aimed to increase donor safety and an early psychiatric review. Particular attention is paid to the motivation of the donor, their understanding of the organ donation process and its potential outcomes, past history of altruistic acts, and a logical rationale for donation. Results: Since beginning our liver transplant (LT) program in 1985, we have performed 2574 adult and 319 paediatric LT. We began LDLT in 2007 and we have had 821 enquiries that converted into 321 live donor assessments and 84 LDLT. Of those enquiries, 85 represented NDAD (10%). They were predominantly males (63%), median age 40 years (range 18-60); 7 had previously donated a kidney. The main reasons for not progressing to donation were failure to engage after an initial enquiry (45%), or medical conditions precluding donation (30%). 11 progressed to donation (13%): 8 males, median age 26 years (19-54), all Caucasian, 8 single, and 1 after kidney donation. 10 donated a left lateral segment graft and 1 a right liver graft. The median hospital stay was 4 days (4-7), and the post-operative complications rate was 18%, all Clavien-Dindo grade 1. Conclusion: Our donor cohort was demographically diverse but they all shared a common desire to help others; we found them to be intellectual, psychologically well balanced, self-aware, and with a universal sense of social and personal responsibility. We were able to carry out the surgery safely. We suggest that experienced LDLT programs should consider NDAD liver transplantation.