Neuropsychiatric conditions have been linked to around 14 percent of the global disease burden, mainlydue to the chronically debilitating nature of depression and other widespread mental disorders, alcohol anddrug use disorders, and psychosis. The science and lay press have confirmed that vitamin D is an importantfactor that can have major health benefits in the prevention and treatment of many chronic diseases. Mostpeople have inadequate vitamin D levels in this country. This is also relevant for people with depression andother mental illnesses as well. Inadequate food consumption, lifestyle or other factors are a major causes ofVitamin D deficiency. Successful diagnosis and treatment of insufficient levels of vitamin D in people withdepression and other mental illnesses could be a simple and cost-effective therapy that could enhance thelong-term health outcomes and quality of life of patients. It is now well known that omega-3 fatty acids areimportant for physical health, and there is growing evidence that omega-3 fatty acids may also be importantfor mental health. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the two major omega-3fatty acids in fish oil, have essential biological roles within the CNS. DHA is a major structural componentof neuronal membranes, and modifying the neuronal membrane fatty acid composition contributes tofunctional changes in the behaviour of phospholipid membrane-embedded receptors and other proteins.EPA has major physiological roles that can influence the behaviour of neurons. For innumerable aspectsof brain functioning, adequate nutrition is needed. A modifiable risk factor for depression may be the poorquality of diet. The goal was to evaluate and synthesize the existing understanding of the role of nutritionin mental well-being. The risk of depression is increased by low omega-3 fatty acid status. Both fish oil andfolic acid supplements have been successfully used to treat depression. The response to antidepressants isdecreased by folate deficiency. Deficiencies in folate, vitamin B12, Vitamin D, Omega 3 fatty acids, VitaminB6 tend to be more prevalent in depressed individuals than in nondepressed individuals. In this short reviewof Literature we have focused on role of Omega 3 Fatty acids, Vitamin D, Vitamin B12, Vitamin B6 andFolate in Mental wellbeing.