HomeCirculationVol. 111, No. 22Issue Highlights Free AccessIn BriefPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessIn BriefPDF/EPUBIssue Highlights Originally published7 Jun 2005https://doi.org/10.1161/circ.111.22.2865Circulation. 2005;111:2865FREEDOM FROM ATRIAL TACHYARRHYTHMIAS AFTER CATHETER ABLATION OF ATRIAL FIBRILLATION: A RANDOMIZED COMPARISON BETWEEN 2 CURRENT ABLATION STRATEGIES, by Karch et al.Catheter ablation for maintaining sinus rhythm increasingly is considered when atrial fibrillation is highly symptomatic despite antiarrhythmic drug therapy. Rapidly activating regions in and around the pulmonary veins are causative in many patients. Ablation techniques targeting these regions, reported results, and complications vary among centers. Comparative data for different approaches are limited. The randomized trial by Karch et al in this issue of Circulation compared 2 more commonly used approaches: ablation encircling a wide area around the pulmonary vein ostia guided by anatomy, versus an electrogram-guided approach ablating only segments of the pulmonary vein ostia. In contrast to a previous trial, the segmental ablation approach was associated with better arrhythmia control. Many recurrences were asymptomatic in both groups. Serious complications included tamponade, pulmonary vein stenosis, and thromboemboli. These findings add fuel to the continuing controversy as to the optimal method and support the practice of confining this procedure to highly symptomatic patients. See p 2875.PERCUTANEOUS CORONARY INTERVENTION VERSUS CONSERVATIVE THERAPY IN NONACUTE CORONARY ARTERY DISEASE: A META-ANALYSIS, by Katritsis and Ioannidis.Clinicians have often debated the incremental benefit of percutaneous coronary interventions for patients with stable angina. This study sought to synthesize the existing data by conducting a meta-analysis of the 11 randomized clinical trials of medical therapy versus percutaneous coronary intervention (PCI) in patients with angiographically documented coronary stenoses in nonacute coronary artery disease settings. The study specifically sought to determine whether PCI was associated with a subsequent reduction in risk of mortality, cardiac death or myocardial infarction, nonfatal myocardial infarction, and coronary artery bypass grafting or PCI. The follow-up was more than 2 years for 5 of the studies. This meta-analysis provides the best current evidence about whether PCI for patients with stable angina does more than improve symptoms. See p 2906.REDUCED NUMBER OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS PREDICTS FUTURE CARDIOVASCULAR EVENTS: PROOF OF CONCEPT FOR THE CLINICAL IMPORTANCE OF ENDOGENOUS VASCULAR REPAIR, by Schmidt-Lucke et al.Endothelial function has been linked to the future risk of cardiovascular events in patients at risk. An emerging concept in vascular disease is the notion that circulating endothelial progenitor cells repopulate the vasculature to preserve normal endothelial function. Cardiovascular risk factors have been associated with a reduced number of circulating endothelial progenitor cells, suggesting that availability of these cells is key to maintaining normal vascular function. In this issue, Schmidt-Lucke and colleagues add important new information to this paradigm by demonstrating that the availability of endothelial progenitor cells is directly linked to the future incidence of cardiovascular events. See p 2981.Visit www.circ.ahajournals.org:Images in Cardiovascular MedicineSpontaneous Left Atrial Dissection Presenting as Pulmonary Edema. See p e372.ST Elevation During Open Heart Surgery: Floating Air Bubble in Saphenous Vein Graft. See p e374.Fluorine-18–Labeled Deoxyglucose Positron Emission Tomography in the Diagnosis and Management of Aortitis With Pulmonary Artery Involvement. See p e375.Download figureDownload PowerPointCorrespondenceSee p e377. Previous Back to top Next FiguresReferencesRelatedDetails June 7, 2005Vol 111, Issue 22 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.111.22.2865 Originally publishedJune 7, 2005 PDF download Advertisement
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