Recently, the necessity of reducing the probability of spread of viruses has fostered the creativity of engineers to develop tools that would allow actions of every-day life to be executed differently. Moreover, the maturity of the Fused Filament Fabrication (FFF) technology and the associated low costs has allowed creative solutions to be produced and used in real-life applications. A distinctive example is represented by the common action of opening a door. Since hands are a typical vector of contamination for viruses such as Coronavirus, hands-free devices aim at making use of the existing structure and kinematic to complete the same action in a different fashion. Typically, the mechanical and manufacturing requirements of these devices include a suitable stiffness-to-mass ratio, a reduced printing time as well as the minimization of supports which need to be removed in a post-printing phase. To tackle all these requirements a dedicated topology optimization (TO) method can be used since the preliminary design phase. Several design requirements of different nature can be included in the problem formulation: mechanical ones, like mass and stiffness, and manufacturing ones, like drawing direction or minimum member size. In this paper, a feasibility study on a hands-free 3D printed door opener has been carried out by means of the Solid Isotropic Material with Penalization (SIMP) method for TO and its CAD-compatible variant, i.e., the SIMP approach reformulated in the framework of non-uniform rational basis spline hyper-surfaces. The aim of the study is to identify optimal solutions to be adapted to a real-case scenario wherein different loading cases and manufacturing constraints are evaluated. Different optimal solutions are obtained, reconstructed to be compatible with CAD environment and the optimized geometry numerically assessed. Finally, the optimal solutions are also evaluated with respect to indicators such as printing time, total filament mass and mass of the supports required by the printing process.